aqp3.L aquaporin 3 (Gill blood group) L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: aqp3.L
Official Full Name: aquaporin 3 (Gill blood group) L homeolog
Primary source: Xenbase:XB-GENE-6255923
Locus tag: XELAEV_18008517mg
See related: EnsemblRapid:ENSXLAG00005001371 AllianceGenome:Xenbase:XB-GENE-6255923
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: aqp-3; aqp3b; AQP-x3; aqp-3b; aqp3-a; aqp3-b; Aquaporin-3
Summary: Predicted to enable glycerol channel activity; urea transmembrane transporter activity; and water channel activity. Predicted to act upstream of or within glycerol transmembrane transport and water transport. Predicted to be located in basolateral plasma membrane. Is expressed in ectoderm and nervous system. Orthologous to human AQP3 (aquaporin 3 (Gill blood group)). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1L

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (228561354..228623084, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (215402634..215423495, complement)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Merging model suggests that aqp3b is part of a mechanism that promotes proper interaction between cells and the extracellular matrix, thereby playing a critical role in gastrulation.
Title: Roles for Xenopus aquaporin-3b (aqp3.L) during gastrulation: Fibrillar fibronectin and tissue boundary establishment in the dorsal margin.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables channel activity	IEA Inferred from Electronic Annotation more info
enables glycerol channel activity	IEA Inferred from Electronic Annotation more info
enables urea transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables water channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glycerol transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within polyol transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within water transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aquaporin 3 (Gill blood group) L homeolog

Names: aquaporin-3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001094477.1 → NP_001087946.1 aquaporin 3 (Gill blood group) L homeolog

See identical proteins and their annotated locations for NP_001087946.1

Status: PROVISIONAL

Source sequence(s)

BC077577

UniProtKB/TrEMBL

A0A974E333, Q6DDI5, Q6IRR9

Related

ENSXLAP00005004162.1, ENSXLAT00005004228.1

Conserved Domains (1) summary

cd00333
Location:23 → 264

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

228561354..228623084 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041581724.1 → XP_041437658.1 aquaporin 3 (Gill blood group) L homeolog isoform X1

UniProtKB/TrEMBL

A0A974E333, Q6DDI5, Q6IRR9

Related

ENSXLAP00005004160.1, ENSXLAT00005004226.1

Conserved Domains (1) summary

cd00333
Location:23 → 264

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...