Kctd10 potassium channel tetramerization domain containing 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Kctd10provided by RGD
Full Name: potassium channel tetramerization domain containing 10provided by RGD
Primary source: RGD:1591979
See related: EnsemblRapid:ENSRNOG00000047896 AllianceGenome:RGD:1591979
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Notch binding activity and identical protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in negative regulation of Rho protein signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to act upstream of or within circulatory system development; negative regulation of Notch signaling pathway; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex and MKS complex. Orthologous to human KCTD10 (potassium channel tetramerization domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 251.9), Heart (RPKM 163.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (47890777..47909391)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (42230159..42248792)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (47992079..48010531)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Notch binding	IEA Inferred from Electronic Annotation more info
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of MKS complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

Names: BTB/POZ domain-containing protein KCTD10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009973.1 → NP_001009973.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

See identical proteins and their annotated locations for NP_001009973.1

Status: PROVISIONAL

Source sequence(s)

AY318756

UniProtKB/Swiss-Prot

Q7TPL3

UniProtKB/TrEMBL

A0A8L2QWU8, A6J204

Conserved Domains (2) summary

smart00225
Location:33 → 131

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam02214
Location:34 → 124

BTB_2; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

47890777..47909391

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249463.5 → XP_006249525.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform X1

UniProtKB/TrEMBL

A0A8I6GF35, A0A8L2QWU8

Related

ENSRNOP00000065635.3, ENSRNOT00000073019.4

Conserved Domains (2) summary

smart00225
Location:33 → 131

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam02214
Location:34 → 124

BTB_2; BTB/POZ domain
XM_063271571.1 → XP_063127641.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform X2

Related

ENSRNOP00000086565.2, ENSRNOT00000103729.2