U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fbxl16 F-box and leucine-rich repeat protein 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 494223, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Symbol
Fbxl16provided by RGD
Full Name
F-box and leucine-rich repeat protein 16provided by RGD
Primary source
RGD:1309127
See related
EnsemblRapid:ENSRNOG00000022248 AllianceGenome:RGD:1309127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Scirr1
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm. Orthologous to human FBXL16 (F-box and leucine rich repeat protein 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 229.1) and Adrenal (RPKM 11.7) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Fbxl16 in Genome Data Viewer
Location:
10q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15333996..15346253)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14829453..14841739)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15176489..15188729)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 78 Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene WD repeat domain 24 Neighboring gene jumonji domain containing 8 Neighboring gene STIP1 homology and U-box containing protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and characterization of scirr1, a novel gene up-regulated after spinal cord injury. Liu T, et al. Exp Mol Med, 2007 Jun 30. PMID 17603280
  2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SCIRR1 ise involved in the succeeding injury and/or repair processes of the injured spinal cord
    Title: Identification and characterization of scirr1, a novel gene up-regulated after spinal cord injury.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
F-box/LRR-repeat protein 16
Names
spinal cord injury and regeneration related 1
spinal cord injury and regeneration-related protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009504.3 → NP_001009504.1  F-box/LRR-repeat protein 16

    See identical proteins and their annotated locations for NP_001009504.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q5MJ12
    UniProtKB/TrEMBL
    A6HD57
    Related
    ENSRNOP00000102449.1, ENSRNOT00000157201.1
    Conserved Domains (2) summary
    cd09293
    Location:201 → 413
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:220 → 243
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15333996..15346253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086539.2 → XP_038942467.1  F-box/LRR-repeat protein 16 isoform X1

    Related
    ENSRNOP00000035846.2, ENSRNOT00000039777.3
    Conserved Domains (2) summary
    cd09293
    Location:201 → 422
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:195 → 219
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. XM_039086540.2 → XP_038942468.1  F-box/LRR-repeat protein 16 isoform X1

    Conserved Domains (2) summary
    cd09293
    Location:201 → 422
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:195 → 219
    LRR_AMN1; leucine-rich repeat [structural motif]

  3. XM_063269580.1 → XP_063125650.1  F-box/LRR-repeat protein 16 isoform X2

    UniProtKB/Swiss-Prot
    Q5MJ12
    UniProtKB/TrEMBL
    A6HD57
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5MJ12.1 GenPept UniProtKB/Swiss-Prot:Q5MJ12

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous