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Eogt EGF domain specific O-linked N-acetylglucosamine transferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 494219, updated on 28-Oct-2024

Summary

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Official Symbol
Eogtprovided by RGD
Official Full Name
EGF domain specific O-linked N-acetylglucosamine transferaseprovided by RGD
Primary source
RGD:1359357
See related
EnsemblRapid:ENSRNOG00000024533 AllianceGenome:RGD:1359357
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aer61
Summary
Predicted to enable protein O-acetylglucosaminyltransferase activity. Predicted to be involved in protein O-GlcNAcylation via threonine. Predicted to be active in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human EOGT (EGF domain specific O-linked N-acetylglucosamine transferase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Adrenal (RPKM 116.3), Lung (RPKM 109.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eogt in Genome Data Viewer
Location:
4q34
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (131275587..131313243, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (129718897..129756558, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (129477779..129515435, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 4 Neighboring gene uncharacterized LOC134486820 Neighboring gene uncharacterized LOC134486821 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene TATA element modulatory factor 1 Neighboring gene ubiquitin-like modifier activating enzyme 3 Neighboring gene ADP-ribosylation factor like GTPase 6 interacting protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1. Sakaidani Y, et al. Biochem Biophys Res Commun, 2012 Mar 2. PMID 22310717
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein O-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein O-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein O-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein O-acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein O-GlcNAcylation via threonine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
EGF domain-specific O-linked N-acetylglucosamine transferase
Names
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
extracellular O-linked N-acetylglucosamine transferase
glycosyltransferase Aer61
NP_001009502.1
XP_008761367.1
XP_017448253.1
XP_017448254.1
XP_017448255.1
XP_038963971.1
XP_038963972.1
XP_063142516.1
XP_063142517.1
XP_063142519.1
XP_063142520.1
XP_063142521.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009502.2 → NP_001009502.1  EGF domain-specific O-linked N-acetylglucosamine transferase precursor

    See identical proteins and their annotated locations for NP_001009502.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q5NDL0
    UniProtKB/TrEMBL
    A6IBF3
    Conserved Domains (1) summary
    pfam04577
    Location:245 → 468
    DUF563; Protein of unknown function (DUF563)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    131275587..131313243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592766.3 → XP_017448255.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X4

    Related
    ENSRNOP00000105223.1, ENSRNOT00000130855.1
    Conserved Domains (1) summary
    pfam04577
    Location:253 → 476
    DUF563; Protein of unknown function (DUF563)

  2. XM_039108043.2 → XP_038963971.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X3

    Conserved Domains (1) summary
    pfam04577
    Location:283 → 477
    DUF563; Protein of unknown function (DUF563)

  3. XM_063286449.1 → XP_063142519.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X5

    UniProtKB/Swiss-Prot
    Q5NDL0
    UniProtKB/TrEMBL
    A6IBF3

  4. XM_008763145.4 → XP_008761367.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X2

    UniProtKB/TrEMBL
    A0A0G2K4R9
    Related
    ENSRNOP00000073147.2, ENSRNOT00000077530.3
    Conserved Domains (1) summary
    pfam04577
    Location:282 → 505
    DUF563; Protein of unknown function (DUF563)

  5. XM_017592764.3 → XP_017448253.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4R9
    Related
    ENSRNOP00000105600.1, ENSRNOT00000154943.1
    Conserved Domains (1) summary
    pfam04577
    Location:283 → 506
    DUF563; Protein of unknown function (DUF563)

  6. XM_063286446.1 → XP_063142516.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X1

  7. XM_063286447.1 → XP_063142517.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X4

  8. XM_017592765.3 → XP_017448254.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4R9
    Conserved Domains (1) summary
    pfam04577
    Location:283 → 506
    DUF563; Protein of unknown function (DUF563)

  9. XM_063286450.1 → XP_063142520.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X5

    UniProtKB/Swiss-Prot
    Q5NDL0
    UniProtKB/TrEMBL
    A6IBF3

  10. XM_039108044.2 → XP_038963972.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X7

    Conserved Domains (1) summary
    pfam04577
    Location:8 → 231
    DUF563; Protein of unknown function (DUF563)

  11. XM_063286451.1 → XP_063142521.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X6

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5NDL0.1 GenPept UniProtKB/Swiss-Prot:Q5NDL0

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