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SPANXN5 SPANX family member N5 [ Homo sapiens (human) ]

Gene ID: 494197, updated on 5-Mar-2024

Summary

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Official Symbol
SPANXN5provided by HGNC
Official Full Name
SPANX family member N5provided by HGNC
Primary source
HGNC:HGNC:33178
See related
Ensembl:ENSG00000204363 MIM:300668; AllianceGenome:HGNC:33178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT11.10; SPANX-N5
Expression
Restricted expression toward testis (RPKM 8.4) See more
Orthologs
all
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Genomic context

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See SPANXN5 in Genome Data Viewer
Location:
Xp11.22
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (52796144..52797427, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (52081055..52082338, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (52825184..52826467, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene S100A11 pseudogene 8 Neighboring gene SSX family member 21, pseudogene Neighboring gene X antigen family member 5 Neighboring gene X antigen family member 3-like Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:52855217-52856182

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. Westbrook VA, et al. Mol Hum Reprod, 2006 Nov. PMID 17012309
  2. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. Kouprina N, et al. Proc Natl Acad Sci U S A, 2004 Mar 2. PMID 14973187, Free PMC Article
  3. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Müller PM, et al. Nat Cell Biol, 2020 Apr. PMID 32203420
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
sperm protein associated with the nucleus on the X chromosome N5
Names
cancer/testis antigen family 11, member 10
nuclear-associated protein SPAN-Xn5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009616.4 → NP_001009616.1  sperm protein associated with the nucleus on the X chromosome N5

    See identical proteins and their annotated locations for NP_001009616.1

    Status: VALIDATED

    Source sequence(s)
    AC244505, AL039107
    Consensus CDS
    CCDS35295.1
    UniProtKB/Swiss-Prot
    Q5MJ07
    Related
    ENSP00000364661.3, ENST00000375511.4
    Conserved Domains (1) summary
    pfam07458
    Location:1 → 72
    SPAN-X; Sperm protein associated with nucleus, mapped to X chromosome

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    52796144..52797427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    52081055..52082338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5MJ07.1 GenPept UniProtKB/Swiss-Prot:Q5MJ07

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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