FOS Fos proto-oncogene, AP-1 transcription factor subunit [Felis catus (domestic cat)] - Gene

Summary

Official Symbol: FOS
Official Full Name: Fos proto-oncogene, AP-1 transcription factor subunit
Primary source: VGNC:VGNC:62329
See related: EnsemblRapid:ENSFCTG00005012814
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Felis catus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Also known as: c-fos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: B3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
105	current	F.catus_Fca126_mat1.0 (GCF_018350175.1)	B3	NC_058373.1 (120100001..120103418)
104	previous assembly	Felis_catus_9.0 (GCF_000181335.3)	B3	NC_018728.3 (122573803..122577106)

Chromosome B3 - NC_058373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

c-Fos-positive cells in the left spinal nucleus of the trigeminus, the bilateral insula, and the bilateral operculum increased.
Title: The changes of c-Fos expression by motor cortex stimulation in the deafferentation pain model.
Expression of the immediate early gene c-Fos as a marker for neurons activated by stimulation of the otoliths or the semicircular canals engages brainstem structures both within and outside of the vestibular nuclear complex (VNC).
Title: Otolith stimulation induces c-Fos expression in vestibular and precerebellar nuclei in cats and squirrel monkeys.
In the retina injury, the intracellular down-regulation of Fos rather than a decline in the number of Fos-immunoreactive nuclei. Interestingly, the infragranular layers displayed more Fos-immunoreactive neurons in experimental animals.
Title: Retinal lesions induce layer-specific Fos expression changes in cat area 17.
The presence of c-jun and c-fos proteins in neurons and glial cells of normal cats indicates that they have ongoing physiological functions in the dorsal root ganglion and spinal cord.
Title: Effects of electro-acupuncture on the expression of c-jun and c-fos in spared dorsal root ganglion and associated spinal laminae following removal of adjacent dorsal root ganglia in cats.
C-fos protein labeled cells in laminae VII, VIII, and X are premotor interneurons involved in the production of locomotion, whereas the laminae III and IV cells are those activated during locomotion due to afferent feedback from the moving limb
Title: Localization of spinal neurons activated during locomotion using the c-fos immunohistochemical method.

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General gene information

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Markers

WI-19801 (e-PCR)
- UniSTS:18950

Fos (e-PCR), detects polymorphism
- UniSTS:143125

G06585 (e-PCR)
- UniSTS:62751

FOS (e-PCR)
- UniSTS:497790

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein c-Fos; proto-oncogene c-Fos

Names: cellular oncogene fos; proto-oncogene protein c-fos; proto-oncogene protein cFOS; transcription factor AP-1 subunit c-Fos; v-fos FBJ murine osteosarcoma viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009341.1 → NP_001009341.1 protein c-Fos

See identical proteins and their annotated locations for NP_001009341.1

Status: PROVISIONAL

Source sequence(s)

AF540379

UniProtKB/Swiss-Prot

Q2PZG4, Q8HZP6

Related

ENSFCTP00005025171.1, ENSFCTT00005036379.1

Conserved Domains (1) summary

cd14721
Location:148 → 201

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

NC_058373.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

Range

120100001..120103418

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_045058690.1 → XP_044914625.1 proto-oncogene c-Fos isoform X1

UniProtKB/TrEMBL

A0A2I2UY61

Related

ENSFCTP00005025144.1, ENSFCTT00005036350.1

Conserved Domains (1) summary

cl21462
Location:132 → 165

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain