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HCG11 HLA complex group 11 [ Homo sapiens (human) ]

Gene ID: 493812, updated on 19-Feb-2024

Summary

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Official Symbol
HCG11provided by HGNC
Official Full Name
HLA complex group 11provided by HGNC
Primary source
HGNC:HGNC:17707
See related
Ensembl:ENSG00000228223 AllianceGenome:HGNC:17707
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bK14H9.3; CTA-14H9.3
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Genomic context

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See HCG11 in Genome Data Viewer
Location:
6p22.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26521706..26527393)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26390105..26395792)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26521934..26527621)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986583 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17010 Neighboring gene RNA, U6 small nuclear 502, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17011 Neighboring gene tRNA-Leu (anticodon CAG) 1-7 Neighboring gene CRISPRi-validated cis-regulatory element chr6.1172 Neighboring gene tRNA-Thr (anticodon AGT) 2-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:26536291-26536790 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26536880-26537544 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:26537578-26537871 Neighboring gene tRNA-Arg (anticodon ACG) 1-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. lncRNA HCG11 suppresses cell proliferation in hormone receptor-positive breast cancer via SRSF1/β-catenin. Xie D, et al. Aging (Albany NY), 2023 Jan 4. PMID 36602530, Free PMC Article
  2. LncRNA HCG11 Accelerates Atherosclerosis via Regulating the miR-224-3p/JAK1 Axis. Zhou H, et al. Biochem Genet, 2023 Feb. PMID 35931919
  3. LncRNA HCG11 promotes 5-FU resistance of colon cancer cells through reprogramming glucose metabolism by targeting the miR-144-3p-PDK4 axis. Cui Z, et al. Cancer Biomark, 2022. PMID 34542064
  4. Down-regulation of lncRNA HCG11 promotes cell proliferation of oral squamous cell carcinoma through sponging miR-455-5p. Wu J, et al. J Gene Med, 2021 Mar. PMID 33151000
  5. Long noncoding RNA HCG11 inhibited growth and invasion in cervical cancer by sponging miR-942-5p and targeting GFI1. Zhang Y, et al. Cancer Med, 2020 Oct. PMID 32794340, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA HCG11 enhances the chemosensitivity of non-small cell lung cancer cells to Gemcitabine via miR-17-5p/p21 axis.
    Title: LncRNA HCG11 enhances the chemosensitivity of non-small cell lung cancer cells to Gemcitabine via miR-17-5p/p21 axis.
  2. Deregulated Long Non-Coding RNA HCG11 in Cerebral Atherosclerosis Serves as a Biomarker to Predict the Risk of Cerebrovascular Events.
    Title: Deregulated Long Non-Coding RNA HCG11 in Cerebral Atherosclerosis Serves as a Biomarker to Predict the Risk of Cerebrovascular Events.
  3. HCG11 inhibits salivary adenoid cystic carcinoma by upregulating EphA2 via binding to miR-1297.
    Title: HCG11 inhibits salivary adenoid cystic carcinoma by upregulating EphA2 via binding to miR-1297.
  4. lncRNA HCG11 suppresses cell proliferation in hormone receptor-positive breast cancer via SRSF1/beta-catenin.
    Title: lncRNA HCG11 suppresses cell proliferation in hormone receptor-positive breast cancer via SRSF1/β-catenin.
  5. LncRNA HCG11 Accelerates Atherosclerosis via Regulating the miR-224-3p/JAK1 Axis.
    Title: LncRNA HCG11 Accelerates Atherosclerosis via Regulating the miR-224-3p/JAK1 Axis.
  6. Long Non-Coding RNA HCG11 Inhibits Glioma Cells Proliferation and Migration through Decoying miR-590-3p and Up-Regulating CADM2.
    Title: Long Non-Coding RNA HCG11 Inhibits Glioma Cells Proliferation and Migration through Decoying miR-590-3p and Up-Regulating CADM2.
  7. Long-stranded non-coding RNA HCG11 regulates glioma cell proliferation, apoptosis and drug resistance via the sponge MicroRNA-144COX-2 axis.
    Title: Long-stranded non-coding RNA HCG11 regulates glioma cell proliferation, apoptosis and drug resistance via the sponge MicroRNA-144COX-2 axis.
  8. LncRNA HCG11 promotes 5-FU resistance of colon cancer cells through reprogramming glucose metabolism by targeting the miR-144-3p-PDK4 axis.
    Title: LncRNA HCG11 promotes 5-FU resistance of colon cancer cells through reprogramming glucose metabolism by targeting the miR-144-3p-PDK4 axis.
  9. LncRNA HCG11 represses ovarian cancer cell growth via AKT signaling pathway.
    Title: LncRNA HCG11 represses ovarian cancer cell growth via AKT signaling pathway.
  10. Long non-coding RNA HCG11 enhances osteosarcoma phenotypes by sponging miR-1245b-5p that directly inhibits plakophilin 2.
    Title: Long non-coding RNA HCG11 enhances osteosarcoma phenotypes by sponging miR-1245b-5p that directly inhibits plakophilin 2.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • HLA complex group 11 (non-protein coding)

Clone Names

  • FLJ14049, FLJ30357

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026790.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121936
    Related
    ENST00000411553.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    26521706..26527393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791780.1 Reference GRCh38.p14 PATCHES

    Range
    67886..73573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    26390105..26395792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials