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NPPC natriuretic peptide C [ Ovis aries (sheep) ]

Gene ID: 493773, updated on 5-Mar-2024

Summary

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Gene symbol
NPPC
Gene description
natriuretic peptide C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
CNP
Orthologs
human mouse all
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Genomic context

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See NPPC in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 2 NC_056055.1 (233570348..233574986, complement)

Chromosome 2 - NC_056055.1Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 7B Neighboring gene large ribosomal subunit protein uL23-like Neighboring gene uncharacterized LOC132659235 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene DIS3 like 3'-5' exoribonuclease 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056055.1 Chromosome 2 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sustained increases in plasma C-type natriuretic peptides fail to increase concentrations in cerebrospinal fluid: Evidence from pregnant sheep. Wilson MO, et al. Peptides, 2015 Jul. PMID 25913855
  2. The trophoblast binucleate cell is the source of maternal circulating C-type natriuretic peptide during ovine pregnancy. McNeill BA, et al. Placenta, 2011 Sep. PMID 21705079
  3. C-type natriuretic peptide forms in pregnancy: maternal plasma profiles during ovine gestation correlate with placental and fetal maturation. McNeill BA, et al. Endocrinology, 2009 Oct. PMID 19608649
  4. C-type natriuretic peptide forms in the ovine fetal and maternal circulations: evidence for independent regulation and reciprocal response to undernutrition. Prickett TC, et al. Endocrinology, 2007 Aug. PMID 17510241
  5. Regional sampling and the effects of experimental heart failure in sheep: differential responses in A, B and C-type natriuretic peptides. Charles CJ, et al. Peptides, 2006 Jan. PMID 16095755

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CNP peptides in CSF decreased from day 4 to day 87 in pregnant sheep, possibly reflecting an adaptive response of the cerebral vasculature to increased hemodynamic load
    Title: Sustained increases in plasma C-type natriuretic peptides fail to increase concentrations in cerebrospinal fluid: Evidence from pregnant sheep.
  2. Concentrations of CNP forms in placental tissues greatly exceeded those in intercaruncular uterine tissue throughout pregnancy
    Title: The trophoblast binucleate cell is the source of maternal circulating C-type natriuretic peptide during ovine pregnancy.
  3. strong relation to placental and fetal maturation; circulating concentration peaked at about d 120
    Title: C-type natriuretic peptide forms in pregnancy: maternal plasma profiles during ovine gestation correlate with placental and fetal maturation.
  4. Circulating levels of paracrine CNP and amino-terminal fragment CNP are raised in experimental heart failure but to a much lesser degree than atrial peptide (ANP) and brain peptide (BNP).
    Title: Regional sampling and the effects of experimental heart failure in sheep: differential responses in A, B and C-type natriuretic peptides.
  5. CNP is regulated independently in the fetus and mother
    Title: C-type natriuretic peptide forms in the ovine fetal and maternal circulations: evidence for independent regulation and reciprocal response to undernutrition.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor guanylyl cyclase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
C-type natriuretic peptide
Names
natriuretic peptide precursor C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009479.1 → NP_001009479.1  C-type natriuretic peptide precursor

    See identical proteins and their annotated locations for NP_001009479.1

    Status: PROVISIONAL

    Source sequence(s)
    AF037467
    UniProtKB/Swiss-Prot
    P56283
    Conserved Domains (1) summary
    pfam00212
    Location:96 → 126
    ANP; Atrial natriuretic peptide

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056055.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    233570348..233574986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042242670.2 → XP_042098604.1  C-type natriuretic peptide isoform X1

    UniProtKB/Swiss-Prot
    P56283
    Conserved Domains (1) summary
    pfam00212
    Location:96 → 126
    ANP; Atrial natriuretic peptide

  2. XM_027963891.3 → XP_027819692.1  C-type natriuretic peptide isoform X1

    UniProtKB/Swiss-Prot
    P56283
    Conserved Domains (1) summary
    pfam00212
    Location:96 → 126
    ANP; Atrial natriuretic peptide
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56283.1 GenPept UniProtKB/Swiss-Prot:P56283

Gene LinkOut

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