TNF tumor necrosis factor [Felis catus (domestic cat)] - Gene

Summary

Official Symbol: TNF
Official Full Name: tumor necrosis factor
Primary source: VGNC:VGNC:66396
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Felis catus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Also known as: TNFA; TNLG1F
Orthologs: human mouse all
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Genomic context

Location:: chromosome: B2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
105	current	F.catus_Fca126_mat1.0 (GCF_018350175.1)	B2	NC_058372.1 (30418662..30420419)
104	previous assembly	Felis_catus_9.0 (GCF_000181335.3)	B2	NC_018727.3 (32583572..32585339)

Chromosome B2 - NC_058372.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

demonstration that Foxp3 inhibits IL2, TNFalpha, and IFNgamma transcription by binding to their promoter regions in lentivirus-specific CD8(+) T cells; this is the first description of this process during the course of AIDS lentiviral infection
Title: T Regulatory Cell Induced Foxp3 Binds the IL2, IFNγ, and TNFα Promoters in Virus-Specific CD8(+) T Cells from Feline Immunodeficiency Virus Infected Cats.
A promoter variant, fTNFA - 421 T, was found to be a disease-resistance allele. One SNP was identified in the extracellular domain (ECD) of fCD209 at position +1900, a G to A substitution, and the A allele was associated with FIP susceptibility.
Title: Polymorphisms in the feline TNFA and CD209 genes are associated with the outcome of feline coronavirus infection.
Small quantities of feline immunodeficiency virus in the brain together with TNF-alpha have the potential to stimulate greater cell and viral entry into the CNS and this is likely to involve important factors other than further TNF-alpha production
Title: Lymphocyte migration through the blood-brain barrier (BBB) in feline immunodeficiency virus infection is significantly influenced by the pre-existence of virus and tumour necrosis factor (TNF)-alpha within the central nervous system (CNS): studies using an in vitro feline BBB model.

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General gene information

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Markers

Tnf (e-PCR), detects polymorphism
- UniSTS:144649

GDB:624603 (e-PCR)
- UniSTS:158353

GDB:624619 (e-PCR)
- UniSTS:158354

PMC165077P1 (e-PCR)
- UniSTS:271531

TNF (e-PCR), detects polymorphism
- UniSTS:264951

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables CD40 receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor

Names: TNF-a; TNF-alpha; cachectin; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.