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HSD17B4 hydroxysteroid 17-beta dehydrogenase 4 [ Bos taurus (domestic cattle) ]

Gene ID: 493643, updated on 10-Oct-2024

Summary

Official Symbol
HSD17B4provided by VGNC
Official Full Name
hydroxysteroid 17-beta dehydrogenase 4provided by VGNC
Primary source
VGNC:VGNC:29975
See related
Ensembl:ENSBTAG00000006978
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
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Genomic context

See HSD17B4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (34291146..34425550, complement)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein mL53-like Neighboring gene protein FAM170A Neighboring gene uncharacterized LOC100295797 Neighboring gene TNF alpha induced protein 8 Neighboring gene Dmx like 1

Genomic regions, transcripts, and products

Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Pathways from PubChem

General protein information

Preferred Names
peroxisomal multifunctional enzyme type 2
Names
multifunctional protein 2
NP_001007810.1
XP_015327614.1
XP_059743942.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007809.2NP_001007810.1  peroxisomal multifunctional enzyme type 2

    See identical proteins and their annotated locations for NP_001007810.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ810541
    UniProtKB/TrEMBL
    F1MZW9, Q0IIL6, Q68V19
    Related
    ENSBTAP00000009173.6, ENSBTAT00000009173.7
    Conserved Domains (6) summary
    PLN02864
    Location:317605
    PLN02864; enoyl-CoA hydratase
    cd05353
    Location:5254
    hydroxyacyl-CoA-like_DH_SDR_c-like; (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs
    PRK05653
    Location:6226
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
    cd03448
    Location:485605
    HDE_HSD; HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.
    pfam02036
    Location:628731
    SCP2; SCP-2 sterol transfer family
    cl00509
    Location:375448
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    34291146..34425550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059887959.1XP_059743942.1  peroxisomal multifunctional enzyme type 2 isoform X2

  2. XM_015472128.3XP_015327614.1  peroxisomal multifunctional enzyme type 2 isoform X1

    UniProtKB/TrEMBL
    A0AAA9TEQ9, F1MZW9, Q0IIL6
    Related
    ENSBTAP00000095304.1, ENSBTAT00000130775.1
    Conserved Domains (6) summary
    PLN02864
    Location:317605
    PLN02864; enoyl-CoA hydratase
    cd05353
    Location:5254
    hydroxyacyl-CoA-like_DH_SDR_c-like; (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs
    PRK05653
    Location:6226
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
    cd03448
    Location:485605
    HDE_HSD; HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.
    pfam02036
    Location:628707
    SCP2; SCP-2 sterol transfer family
    cl00509
    Location:375448
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...