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asah2 N-acylsphingosine amidohydrolase 2 [ Danio rerio (zebrafish) ]

Gene ID: 493602, updated on 2-Nov-2024

Summary

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Official Symbol
asah2provided by ZNC
Official Full Name
N-acylsphingosine amidohydrolase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-041112-1
See related
Ensembl:ENSDARG00000012829 AllianceGenome:ZFIN:ZDB-GENE-041112-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables N-acylsphingosine amidohydrolase activity. Acts upstream of or within ceramide metabolic process. Located in Golgi membrane; apical plasma membrane; and endoplasmic reticulum membrane. Orthologous to human ASAH2 (N-acylsphingosine amidohydrolase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See asah2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (6117682..6142308)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (6084098..6108724)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene alanyl-tRNA synthetase domain containing 1 Neighboring gene sphingomyelin synthase 1b Neighboring gene uncharacterized LOC103911899 Neighboring gene RAMP-like triterpene glycoside receptor Neighboring gene apobec1 complementation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and functional analysis of zebrafish neutral ceramidase. Yoshimura Y, et al. J Biol Chem, 2004 Oct 15. PMID 15271994
  2. The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis. Mendelson K, et al. Elife, 2017 Sep 28. PMID 28956531, Free PMC Article
  3. Atp7b deficiency induces zebrafish eye developmental defects. Wu Y, et al. Metallomics, 2023 May 2. PMID 37070960
  4. 3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish. Park KH, et al. Sci Rep, 2019 Feb 4. PMID 30718751, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. essential for metabolism of ceramide and the early development of zebrafish.
    Title: Molecular cloning and functional analysis of zebrafish neutral ceramidase.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables N-acylsphingosine amidohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acylsphingosine amidohydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acylsphingosine amidohydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ceramide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ceramide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ceramide catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within ceramide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingosine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sphingosine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in caveola IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
neutral ceramidase
Names
N-CDase
NCDase
acylsphingosine deacylase 2
non-lysosomal ceramidase
znCD
NP_001007764.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007763.1 → NP_001007764.1  neutral ceramidase

    See identical proteins and their annotated locations for NP_001007764.1

    Status: PROVISIONAL

    Source sequence(s)
    AB194413
    UniProtKB/Swiss-Prot
    Q5W7F1
    Related
    ENSDARP00000119244.1, ENSDART00000146650.2
    Conserved Domains (3) summary
    PTZ00487
    Location:61 → 736
    PTZ00487; ceramidase; Provisional
    pfam04734
    Location:61 → 567
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:569 → 736
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    6117682..6142308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5W7F1.1 GenPept UniProtKB/Swiss-Prot:Q5W7F1

Gene LinkOut

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