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gmppb GDP-mannose pyrophosphorylase B [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 493267, updated on 4-Nov-2024

Summary

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Official Symbol
gmppbprovided by Xenbase
Official Full Name
GDP-mannose pyrophosphorylase Bprovided by Xenbase
Primary source
Xenbase:XB-GENE-922650
See related
Ensembl:ENSXETG00000005954 AllianceGenome:Xenbase:XB-GENE-922650
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
gmppb-a; gmppb-b
Summary
Predicted to enable mannose-1-phosphate guanylyltransferase (GTP) activity. Predicted to be involved in GDP-mannose biosynthetic process and protein glycosylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2T; congenital muscular dystrophy-dystroglycanopathy A14; muscular dystrophy-dystroglycanopathy; and muscular dystrophy-dystroglycanopathy type B14. Orthologous to human GMPPB (GDP-mannose pyrophosphorylase B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See gmppb in Genome Data Viewer
Location:
chromosome: 4
Exon count:
11
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (126012667..126024526, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 4 NC_030680.1 (115593665..115605489, complement)

Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene macrophage stimulating 1 Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig-like domain 3 Neighboring gene inositol hexaphosphate kinase 1 Neighboring gene uncharacterized LOC105947714 Neighboring gene cadherin related family member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC89813

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables mannose-1-phosphate guanylyltransferase (GTP) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannose-1-phosphate guanylyltransferase (GTP) activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GDP-mannose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within GDP-mannose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within GDP-mannose biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mannose-1-phosphate guanylyltransferase catalytic subunit beta; mannose-1-phosphate guanyltransferase beta
Names
GTP-mannose-1-phosphate guanylyltransferase beta
NP_001008434.1
XP_012820013.1
XP_012820014.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008434.2 → NP_001008434.1  mannose-1-phosphate guanylyltransferase catalytic subunit beta

    See identical proteins and their annotated locations for NP_001008434.1

    Status: PROVISIONAL

    Source sequence(s)
    BC080150
    UniProtKB/Swiss-Prot
    Q68EQ1
    UniProtKB/TrEMBL
    A0A6I8Q4B8
    Related
    ENSXETP00000064398.2, ENSXETT00000104353.2
    Conserved Domains (2) summary
    cd06425
    Location:1 → 233
    M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
    cl00160
    Location:255 → 334
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    126012667..126024526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012964560.3 → XP_012820014.1  mannose-1-phosphate guanyltransferase beta isoform X2

    See identical proteins and their annotated locations for XP_012820014.1

    UniProtKB/Swiss-Prot
    Q68EQ1
    UniProtKB/TrEMBL
    A0A6I8Q4B8
    Conserved Domains (2) summary
    cd06425
    Location:1 → 233
    M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
    cl00160
    Location:255 → 334
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

  2. XM_012964559.3 → XP_012820013.1  mannose-1-phosphate guanyltransferase beta isoform X1

    UniProtKB/TrEMBL
    A0A5S6KW99, A0A6I8Q4B8
    Related
    ENSXETP00000013087.5, ENSXETT00000013087.5
    Conserved Domains (2) summary
    cd06425
    Location:8 → 240
    M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
    cl00160
    Location:262 → 341
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68EQ1.1 GenPept UniProtKB/Swiss-Prot:Q68EQ1

Gene LinkOut

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