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aldh16a1 aldehyde dehydrogenase 16 family, member A1 [ Danio rerio (zebrafish) ]

Gene ID: 492710, updated on 2-Nov-2024

Summary

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Official Symbol
aldh16a1provided by ZNC
Official Full Name
aldehyde dehydrogenase 16 family, member A1provided by ZNC
Primary source
ZFIN:ZDB-GENE-070112-2062
See related
Ensembl:ENSDARG00000037935 AllianceGenome:ZFIN:ZDB-GENE-070112-2062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7151472; zgc:158277
Summary
Predicted to enable oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Is expressed in several structures, including intermediate cell mass of mesoderm; liver; neural tube; spinal cord; and vasculature. Orthologous to human ALDH16A1 (aldehyde dehydrogenase 16 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See aldh16a1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (32080359..32098537)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (31948626..31966823)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490638 Neighboring gene BCL2 associated X, apoptosis regulator b Neighboring gene ferritin, heavy polypeptide-like 27 Neighboring gene ferritin, heavy polypeptide-like 28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. ALDH2 mediates 5-nitrofuran activity in multiple species. Zhou L, et al. Chem Biol, 2012 Jul 27. PMID 22840776, Free PMC Article
  2. Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Brunsdon H, et al. Development, 2022 May 15. PMID 35485397, Free PMC Article
  3. ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Lu Y, et al. Cell Rep, 2024 Jul 23. PMID 38963759, Free PMC Article
  4. A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos. Ma AC, et al. Leukemia, 2010 Dec. PMID 20927131
  5. Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Lou B, et al. Redox Biol, 2020 Oct. PMID 32980661, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC158277

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
aldehyde dehydrogenase family 16 member A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079954.2 → NP_001073423.2  aldehyde dehydrogenase family 16 member A1

    Status: VALIDATED

    Source sequence(s)
    BX511080
    UniProtKB/TrEMBL
    A0A8N1TQ55, F1QGP1
    Related
    ENSDARP00000111827.2, ENSDART00000124943.3
    Conserved Domains (2) summary
    COG1012
    Location:514 → 755
    AdhE; Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase [Energy production and conversion]
    cl11961
    Location:18 → 470
    ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    32080359..32098537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164021.5 → XP_005164078.1  aldehyde dehydrogenase family 16 member A1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BBC0
    Conserved Domains (2) summary
    COG1012
    Location:513 → 754
    AdhE; Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase [Energy production and conversion]
    cl11961
    Location:18 → 469
    ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
Nucleotide Protein Strain
Heading Accession and Version

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