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NUCB2 nucleobindin 2 [ Homo sapiens (human) ]

Gene ID: 4925, updated on 11-Apr-2024

Summary

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Official Symbol
NUCB2provided by HGNC
Official Full Name
nucleobindin 2provided by HGNC
Primary source
HGNC:HGNC:8044
See related
Ensembl:ENSG00000070081 MIM:608020; AllianceGenome:HGNC:8044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEFA; HEL-S-109
Summary
This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]
Expression
Broad expression in bone marrow (RPKM 51.4), salivary gland (RPKM 41.2) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
11p15.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (17276739..17349980)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (17374367..17447613)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (17298286..17353758)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:17216823-17217324 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:17223457-17223958 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:17228800-17229323 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:17229324-17229846 Neighboring gene ribosomal protein L29 pseudogene 21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4486 Neighboring gene ribosomal protein S2 pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3183 Neighboring gene uncharacterized LOC124902640 Neighboring gene uncharacterized LOC105376576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:17373285-17373886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:17373887-17374488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4488 Neighboring gene MPRA-validated peak1220 silencer Neighboring gene natural killer cell cytotoxicity receptor 3 ligand 1 Neighboring gene NANOG hESC enhancer GRCh37_chr11:17397887-17398425 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:17399732-17400931 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:17408081-17408734 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:17408735-17409388 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3185 Neighboring gene potassium inwardly rectifying channel subfamily J member 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway. Ning S, et al. J Transl Med, 2023 Jun 5. PMID 37277807, Free PMC Article
  2. Nesfatin-1 suppresses autophagy of chondrocytes in osteoarthritis via remodeling of cytoskeleton and inhibiting RhoA/ROCK signal pathway. Jiang L, et al. J Orthop Surg Res, 2023 Mar 2. PMID 36859270, Free PMC Article
  3. Nesfatin-1 in Human Milk and Its Association with Infant Anthropometry. Honoré KD, et al. Nutrients, 2022 Dec 30. PMID 36615833, Free PMC Article
  4. Nesfatin-1 Stimulates CCL2-dependent Monocyte Migration And M1 Macrophage Polarization: Implications For Rheumatoid Arthritis Therapy. Chang JW, et al. Int J Biol Sci, 2023. PMID 36594093, Free PMC Article
  5. Does one plus one always equal two? Structural differences between nesfatin-1, -2, and nesfatin-1/2. Lenda R, et al. Cell Commun Signal, 2022 Oct 24. PMID 36280843, Free PMC Article

See all (180) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of Nucleobindin-2 in the Clinical Pathogenesis and Treatment Resistance of Glioblastoma.
    Title: Role of Nucleobindin-2 in the Clinical Pathogenesis and Treatment Resistance of Glioblastoma.
  2. High plasma nesfatin-1 level in Chinese adolescents with depression.
    Title: High plasma nesfatin-1 level in Chinese adolescents with depression.
  3. NUCB2/nesfatin-1 in the acute stress response of obese women with high and low anxiety.
    Title: NUCB2/nesfatin-1 in the acute stress response of obese women with high and low anxiety.
  4. Nucleobindin-2 Mediates Transforming Growth Factor-beta1-Driven Phenotypes in Zinc Finger E-Box Binding Homeobox 1-High Uterine Carcinosarcoma.
    Title: Nucleobindin-2 Mediates Transforming Growth Factor-β1-Driven Phenotypes in Zinc Finger E-Box Binding Homeobox 1-High Uterine Carcinosarcoma.
  5. NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway.
    Title: NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway.
  6. Nesfatin-1 suppresses autophagy of chondrocytes in osteoarthritis via remodeling of cytoskeleton and inhibiting RhoA/ROCK signal pathway.
    Title: Nesfatin-1 suppresses autophagy of chondrocytes in osteoarthritis via remodeling of cytoskeleton and inhibiting RhoA/ROCK signal pathway.
  7. Does NUCB2/Nesfatin-1 Influence Eating Behaviors in Obese Patients with Binge Eating Disorder? Toward a Neurobiological Pathway.
    Title: Does NUCB2/Nesfatin-1 Influence Eating Behaviors in Obese Patients with Binge Eating Disorder? Toward a Neurobiological Pathway.
  8. Nesfatin-1 in Human Milk and Its Association with Infant Anthropometry.
    Title: Nesfatin-1 in Human Milk and Its Association with Infant Anthropometry.
  9. Nesfatin-1 Stimulates CCL2-dependent Monocyte Migration And M1 Macrophage Polarization: Implications For Rheumatoid Arthritis Therapy.
    Title: Nesfatin-1 Stimulates CCL2-dependent Monocyte Migration And M1 Macrophage Polarization: Implications For Rheumatoid Arthritis Therapy.
  10. Does one plus one always equal two? Structural differences between nesfatin-1, -2, and nesfatin-1/2.
    Title: Does one plus one always equal two? Structural differences between nesfatin-1, -2, and nesfatin-1/2.
Submit: New GeneRIF Correction See all GeneRIFs (139)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables G-protein alpha-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ion binding EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in sequestering of metal ion EXP
Inferred from Experiment
more info
 PubMed 
involved_in small GTPase-mediated signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
nucleobindin-2
Names
DNA-binding protein NEFA
epididymis secretory protein Li 109
gastric cancer antigen Zg4
nesfatin 1
novel DNA binding/EF-hand/leucine zipper protein
nucleobinding 2
prepronesfatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330227.3 → NP_001317156.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    UniProtKB/TrEMBL
    J3KQU0, Q2L696
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  2. NM_001352661.2 → NP_001339590.1  nucleobindin-2 isoform 3 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Conserved Domains (2) summary
    PRK12704
    Location:344 → 401
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:248 → 323
    EF-hand_7; EF-hand domain pair

  3. NM_001352662.2 → NP_001339591.1  nucleobindin-2 isoform 4 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Conserved Domains (1) summary
    cl25602
    Location:259 → 370
    DUF3552; Domain of unknown function (DUF3552)

  4. NM_001352663.2 → NP_001339592.1  nucleobindin-2 isoform 3 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Conserved Domains (2) summary
    PRK12704
    Location:344 → 401
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:248 → 323
    EF-hand_7; EF-hand domain pair

  5. NM_001352664.2 → NP_001339593.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  6. NM_001352665.2 → NP_001339594.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    UniProtKB/TrEMBL
    J3KQU0, Q2L696
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  7. NM_001352666.2 → NP_001339595.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    UniProtKB/TrEMBL
    J3KQU0, Q2L696
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  8. NM_001352667.2 → NP_001339596.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    UniProtKB/TrEMBL
    J3KQU0, Q2L696
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  9. NM_001352668.2 → NP_001339597.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  10. NM_001352669.2 → NP_001339598.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  11. NM_001352670.2 → NP_001339599.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  12. NM_001352671.2 → NP_001339600.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    UniProtKB/TrEMBL
    J3KQU0, Q2L696
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  13. NM_001352672.2 → NP_001339601.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  14. NM_005013.4 → NP_005004.1  nucleobindin-2 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_005004.1

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
    Related
    ENSP00000436455.1, ENST00000529010.6
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    17276739..17349980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448553.2 → XP_024304321.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258 → 369
    DUF3552; Domain of unknown function (DUF3552)

  2. XM_024448538.2 → XP_024304306.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  3. XM_024448540.2 → XP_024304308.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  4. XM_024448542.2 → XP_024304310.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  5. XM_024448535.2 → XP_024304303.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  6. XM_047426990.1 → XP_047282946.1  nucleobindin-2 isoform X5

  7. XM_024448527.2 → XP_024304295.1  nucleobindin-2 isoform X1

    Conserved Domains (2) summary
    pfam13499
    Location:248 → 324
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:306 → 399
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family

  8. XM_024448532.2 → XP_024304300.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  9. XM_024448550.2 → XP_024304318.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258 → 369
    DUF3552; Domain of unknown function (DUF3552)

  10. XM_024448533.2 → XP_024304301.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  11. XM_024448551.2 → XP_024304319.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258 → 369
    DUF3552; Domain of unknown function (DUF3552)

  12. XM_024448531.2 → XP_024304299.1  nucleobindin-2 isoform X2

    Related
    ENSP00000320168.6, ENST00000323688.10
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  13. XM_024448549.2 → XP_024304317.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258 → 369
    DUF3552; Domain of unknown function (DUF3552)

  14. XM_024448547.2 → XP_024304315.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  15. XM_047426988.1 → XP_047282944.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

  16. XM_017017812.3 → XP_016873301.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  17. XM_047426992.1 → XP_047282948.1  nucleobindin-2 isoform X6

    UniProtKB/TrEMBL
    J3KQU0, Q2L696

  18. XM_017017814.2 → XP_016873303.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  19. XM_017017828.2 → XP_016873317.1  nucleobindin-2 isoform X6

    UniProtKB/TrEMBL
    J3KQU0, Q2L696
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  20. XM_047426986.1 → XP_047282942.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

  21. XM_017017826.2 → XP_016873315.1  nucleobindin-2 isoform X6

    UniProtKB/TrEMBL
    J3KQU0, Q2L696
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  22. XM_017017818.3 → XP_016873307.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  23. XM_047426983.1 → XP_047282939.1  nucleobindin-2 isoform X2

  24. XM_024448545.2 → XP_024304313.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  25. XM_024448536.2 → XP_024304304.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  26. XM_024448552.2 → XP_024304320.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258 → 369
    DUF3552; Domain of unknown function (DUF3552)

  27. XM_047426982.1 → XP_047282938.1  nucleobindin-2 isoform X1

  28. XM_024448539.2 → XP_024304307.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  29. XM_024448541.2 → XP_024304309.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  30. XM_024448534.2 → XP_024304302.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  31. XM_047426989.1 → XP_047282945.1  nucleobindin-2 isoform X5

  32. XM_047426994.1 → XP_047282950.1  nucleobindin-2 isoform X6

    UniProtKB/TrEMBL
    J3KQU0, Q2L696

  33. XM_017017817.2 → XP_016873306.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  34. XM_047426985.1 → XP_047282941.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

  35. XM_047426991.1 → XP_047282947.1  nucleobindin-2 isoform X6

    UniProtKB/TrEMBL
    J3KQU0, Q2L696

  36. XM_047426984.1 → XP_047282940.1  nucleobindin-2 isoform X3

  37. XM_017017813.2 → XP_016873302.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  38. XM_047426993.1 → XP_047282949.1  nucleobindin-2 isoform X6

    UniProtKB/TrEMBL
    J3KQU0, Q2L696

  39. XM_047426987.1 → XP_047282943.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    17374367..17447613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368902.1 → XP_054224877.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

  2. XM_054368898.1 → XP_054224873.1  nucleobindin-2 isoform X2

  3. XM_054368919.1 → XP_054224894.1  nucleobindin-2 isoform X6

    UniProtKB/TrEMBL
    J3KQU0, Q2L696

  4. XM_054368914.1 → XP_054224889.1  nucleobindin-2 isoform X5

  5. XM_054368892.1 → XP_054224867.1  nucleobindin-2 isoform X2

  6. XM_054368894.1 → XP_054224869.1  nucleobindin-2 isoform X2

  7. XM_054368889.1 → XP_054224864.1  nucleobindin-2 isoform X2

  8. XM_054368912.1 → XP_054224887.1  nucleobindin-2 isoform X5

  9. XM_054368885.1 → XP_054224860.1  nucleobindin-2 isoform X1

  10. XM_054368887.1 → XP_054224862.1  nucleobindin-2 isoform X2

  11. XM_054368915.1 → XP_054224890.1  nucleobindin-2 isoform X5

  12. XM_054368891.1 → XP_054224866.1  nucleobindin-2 isoform X2

  13. XM_054368916.1 → XP_054224891.1  nucleobindin-2 isoform X5

  14. XM_054368886.1 → XP_054224861.1  nucleobindin-2 isoform X2

  15. XM_054368910.1 → XP_054224885.1  nucleobindin-2 isoform X5

  16. XM_054368895.1 → XP_054224870.1  nucleobindin-2 isoform X2

  17. XM_054368903.1 → XP_054224878.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

  18. XM_054368921.1 → XP_054224896.1  nucleobindin-2 isoform X6

    UniProtKB/TrEMBL
    J3KQU0, Q2L696

  19. XM_054368905.1 → XP_054224880.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

  20. XM_054368917.1 → XP_054224892.1  nucleobindin-2 isoform X6

    UniProtKB/TrEMBL
    J3KQU0, Q2L696

  21. XM_054368909.1 → XP_054224884.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

  22. XM_054368907.1 → XP_054224882.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

  23. XM_054368899.1 → XP_054224874.1  nucleobindin-2 isoform X2

  24. XM_054368897.1 → XP_054224872.1  nucleobindin-2 isoform X2

  25. XM_054368890.1 → XP_054224865.1  nucleobindin-2 isoform X2

  26. XM_054368913.1 → XP_054224888.1  nucleobindin-2 isoform X5

  27. XM_054368893.1 → XP_054224868.1  nucleobindin-2 isoform X2

  28. XM_054368896.1 → XP_054224871.1  nucleobindin-2 isoform X2

  29. XM_054368888.1 → XP_054224863.1  nucleobindin-2 isoform X2

  30. XM_054368911.1 → XP_054224886.1  nucleobindin-2 isoform X5

  31. XM_054368922.1 → XP_054224897.1  nucleobindin-2 isoform X6

    UniProtKB/TrEMBL
    J3KQU0, Q2L696

  32. XM_054368908.1 → XP_054224883.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

  33. XM_054368901.1 → XP_054224876.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

  34. XM_054368918.1 → XP_054224893.1  nucleobindin-2 isoform X6

    UniProtKB/TrEMBL
    J3KQU0, Q2L696

  35. XM_054368900.1 → XP_054224875.1  nucleobindin-2 isoform X3

  36. XM_054368904.1 → XP_054224879.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

  37. XM_054368920.1 → XP_054224895.1  nucleobindin-2 isoform X6

    UniProtKB/TrEMBL
    J3KQU0, Q2L696

  38. XM_054368906.1 → XP_054224881.1  nucleobindin-2 isoform X4

    UniProtKB/Swiss-Prot
    A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_132751.1: Suppressed sequence

    Description
    NR_132751.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80303.3 GenPept UniProtKB/Swiss-Prot:P80303

Gene LinkOut

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