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ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 [ Canis lupus familiaris (dog) ]

Gene ID: 491368, updated on 17-Aug-2024

Summary

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Official Symbol
ITIH3provided by VGNC
Official Full Name
inter-alpha-trypsin inhibitor heavy chain 3provided by VGNC
Primary source
VGNC:VGNC:103686
See related
Ensembl:ENSCAFG00845029600
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ITIH3 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (37372140..37386102, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (37003374..37017395, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (37421715..37435675, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (37144184..37158164, complement)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene musculoskeletal, embryonic nuclear protein 1 Neighboring gene inter-alpha-trypsin inhibitor heavy chain H1-like Neighboring gene uncharacterized LOC119864681 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 4 Neighboring gene uncharacterized LOC119864680 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 1 Neighboring gene NIMA related kinase 4 Neighboring gene ATP synthase subunit g, mitochondrial-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
inter-alpha-trypsin inhibitor heavy chain H3
Names
inter-alpha (globulin) inhibitor H3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    37372140..37386102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038427518.1 → XP_038283446.1  inter-alpha-trypsin inhibitor heavy chain H3

    UniProtKB/TrEMBL
    A0A8C0M8V3, A0A8I3QUR2, A0A8P0SJ97
    Related
    ENSCAFP00845041141.1, ENSCAFT00845052439.1
    Conserved Domains (3) summary
    smart00609
    Location:30 → 158
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:281 → 462
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:684 → 872
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    37144184..37158164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038630343.1 → XP_038486271.1  inter-alpha-trypsin inhibitor heavy chain H3

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    37421715..37435675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038566177.1 → XP_038422105.1  inter-alpha-trypsin inhibitor heavy chain H3

    UniProtKB/TrEMBL
    A0A8C0M8V3

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    37003374..37017395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038455172.1 → XP_038311100.1  inter-alpha-trypsin inhibitor heavy chain H3

    UniProtKB/TrEMBL
    A0A8C0M8V3, A0A8I3QUR2, A0A8P0SJ97
    Conserved Domains (3) summary
    smart00609
    Location:30 → 158
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:281 → 462
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:684 → 872
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
Nucleotide Protein
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