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NPY2R neuropeptide Y receptor Y2 [ Homo sapiens (human) ]

Gene ID: 4887, updated on 5-Mar-2024

Summary

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Official Symbol
NPY2Rprovided by HGNC
Official Full Name
neuropeptide Y receptor Y2provided by HGNC
Primary source
HGNC:HGNC:7957
See related
Ensembl:ENSG00000185149 MIM:162642; AllianceGenome:HGNC:7957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPY2-R
Summary
Predicted to enable calcium channel regulator activity and neuropeptide Y receptor activity. Involved in cardiac left ventricle morphogenesis and outflow tract morphogenesis. Located in cilium. Implicated in Huntington's disease; morbid obesity; and obesity. Biomarker of peripheral artery disease and temporal lobe epilepsy. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See NPY2R in Genome Data Viewer
Location:
4q32.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (155173723..155217076)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (158505608..158548978)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (156094875..156138228)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U2 small nuclear 44, pseudogene Neighboring gene RNA binding motif protein 46 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:155837105-155837739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:155875070-155875570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:155875571-155876071 Neighboring gene uncharacterized LOC105377501 Neighboring gene NANOG hESC enhancer GRCh37_chr4:156034857-156035436 Neighboring gene NPY2R antisense RNA 1 Neighboring gene uncharacterized LOC105377502 Neighboring gene MAP9 antisense RNA 1 Neighboring gene microtubule associated protein 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder. Treutlein J, et al. Psychiatr Genet, 2017 Feb. PMID 27584037
  2. On the relevance of the NPY2-receptor variation for modes of action cascading processes. Beste C, et al. Neuroimage, 2014 Nov 15. PMID 25157429
  3. NPY2-receptor variation modulates iconic memory processes. Arning L, et al. Eur Neuropsychopharmacol, 2014 Aug. PMID 24709141
  4. The G-protein-coupled neuropeptide Y receptor type 2 is highly dynamic in lipid membranes as revealed by solid-state NMR spectroscopy. Schmidt P, et al. Chemistry, 2014 Apr 22. PMID 24623336
  5. Ligands of the neuropeptide Y Y2 receptor. Mittapalli GK, et al. Bioorg Med Chem Lett, 2014 Jan 15. PMID 24365162, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
    Title: Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
  2. Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients.
    Title: Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients.
  3. The analysis of the distribution of genotypes in CEP135 rs4865047 and NPY2R rs1902491 detected significant differences only in the single nucleotide polymorphism rs4865047 genotype between the case and control group in comparison to the reference group. No significant association was found for the NPY2R SNP rs1902491 genotype.
    Title: The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus.
  4. genetic variation in NPY and NPY2R is at low frequency and thus does not make a major contribution to the obese phenotype in the general population
    Title: Evaluation of a Role for NPY and NPY2R in the Pathogenesis of Obesity by Mutation and Copy Number Variation Analysis in Obese Children and Adolescents.
  5. The present study explored whether functional NPY2R variant rs6857715 (C-599T) showed an association with Major Depressive Disorder. Analysis of the overall sample (595 MDD cases; 1295 controls) showed an association with the AD risk allele C. The present findings suggest that the NPY2R rs6857715 C-allele makes a genuine contribution toward MDD
    Title: Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder.
  6. not detected in infantile hemanogiomas
    Title: Neuropeptide Y receptor 1 is expressed by B and T lymphocytes and mast cells in infantile haemangiomas.
  7. polymorphisms in the NPY2R gene may be useful in identifying women at risk for osteoporosis.
    Title: Polymorphisms in neuropeptide genes and bone mineral density in Korean postmenopausal women.
  8. The C-terminal alpha-helix of Neuropeptide Y, which is formed in a membrane environment in the absence of the receptor, is unwound starting at T(32) to provide optimal contacts in a binding pocket within the transmembrane bundle of the NPY-Y2 receptor.
    Title: Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y₂ Receptor Binding and Activation.
  9. Data show that the Y2-receptor high expression G allele is associated with a less efficient mode of action cascading where different task goals are activated in parallel.
    Title: On the relevance of the NPY2-receptor variation for modes of action cascading processes.
  10. The molecular mobility of the human neuropeptide Y receptor type 2 reconstituted into dimyristoylphosphatidylcholine (DMPC) membranes was investigated by means of solid-state NMR spectroscopy.
    Title: The G-protein-coupled neuropeptide Y receptor type 2 is highly dynamic in lipid membranes as revealed by solid-state NMR spectroscopy.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel regulator activity TAS
Traceable Author Statement
more info
 PubMed 
enables neuropeptide Y receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables peptide YY receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiac left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotory behavior TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in non-motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
neuropeptide Y receptor type 2
Names
NPY-Y2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000910.4 → NP_000901.1  neuropeptide Y receptor type 2

    See identical proteins and their annotated locations for NP_000901.1

    Status: VALIDATED

    Source sequence(s)
    U36269, U42766
    Consensus CDS
    CCDS3791.1
    UniProtKB/Swiss-Prot
    P49146, Q13281, Q13457, Q4W5G7, Q6AZZ6, Q9UE67
    Related
    ENSP00000332591.3, ENST00000329476.4
    Conserved Domains (1) summary
    cd15399
    Location:51 → 336
    7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001370180.1 → NP_001357109.1  neuropeptide Y receptor type 2

    Status: VALIDATED

    Source sequence(s)
    AC104407
    Consensus CDS
    CCDS3791.1
    UniProtKB/Swiss-Prot
    P49146, Q13281, Q13457, Q4W5G7, Q6AZZ6, Q9UE67
    Related
    ENSP00000426366.1, ENST00000506608.1
    Conserved Domains (1) summary
    cd15399
    Location:51 → 336
    7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001375470.1 → NP_001362399.1  neuropeptide Y receptor type 2

    Status: VALIDATED

    Source sequence(s)
    AC104407
    Consensus CDS
    CCDS3791.1
    UniProtKB/Swiss-Prot
    P49146, Q13281, Q13457, Q4W5G7, Q6AZZ6, Q9UE67
    Conserved Domains (1) summary
    cd15399
    Location:51 → 336
    7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    155173723..155217076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    158505608..158548978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49146.1 GenPept UniProtKB/Swiss-Prot:P49146

Gene LinkOut

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