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TGFB2 transforming growth factor beta 2 [ Canis lupus familiaris (dog) ]

Gene ID: 488596, updated on 5-Mar-2024

Summary

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Official Symbol
TGFB2provided by VGNC
Official Full Name
transforming growth factor beta 2provided by VGNC
Primary source
VGNC:VGNC:47309
See related
Ensembl:ENSCAFG00845028176
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
TGFbeta2
Orthologs
human mouse all
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Genomic context

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See TGFB2 in Genome Data Viewer
Location:
chromosome: 38
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 38 NC_051842.1 (13464207..13544357)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 38 NC_006620.4 (13472728..13552654)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 38 NC_049259.1 (14128921..14209014)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 38 NC_049298.1 (13473487..13553481)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 38 NC_049779.1 (13819811..13899809)

Chromosome 38 - NC_051842.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111094592 Neighboring gene uncharacterized LOC119868038 Neighboring gene ribosomal RNA processing 15 homolog Neighboring gene uncharacterized LOC119868039 Neighboring gene uncharacterized LOC106558346 Neighboring gene uncharacterized LOC111094577 Neighboring gene uncharacterized LOC102156261

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TGF-β2 interfering oligonucleotides used as adjuvants for microbial vaccines. Tu L, et al. J Leukoc Biol, 2020 Nov. PMID 32794350

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TGF-beta2 interfering oligonucleotides used as adjuvants for microbial vaccines.
    Title: TGF-β2 interfering oligonucleotides used as adjuvants for microbial vaccines.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables type II transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables type III transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transforming growth factor beta-2; transforming growth factor beta-2 proprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051842.1 Reference ROS_Cfam_1.0

    Range
    13464207..13544357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038448452.1 → XP_038304380.1  transforming growth factor beta-2 proprotein isoform X3

    Conserved Domains (1) summary
    pfam00688
    Location:21 → 256
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038448450.1 → XP_038304378.1  transforming growth factor beta-2 proprotein isoform X1

    UniProtKB/TrEMBL
    A0A8C0P803, A0A8I3PZZ6, A0A8I3QKA5, A0A8P0P1R2
    Related
    ENSCAFP00845038991.1, ENSCAFT00845049718.1
    Conserved Domains (2) summary
    cd19385
    Location:345 → 441
    TGF_beta_TGFB2; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins
    pfam00688
    Location:21 → 256
    TGFb_propeptide; TGF-beta propeptide

  3. XM_038448451.1 → XP_038304379.1  transforming growth factor beta-2 proprotein isoform X2

    UniProtKB/TrEMBL
    A0A8C0JSS2, A0A8C0RRP5, A0A8I3QKA5, A0A8P0P1R2
    Related
    ENSCAFP00845039028.1, ENSCAFT00845049765.1
    Conserved Domains (2) summary
    cd19385
    Location:317 → 413
    TGF_beta_TGFB2; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins
    pfam00688
    Location:21 → 228
    TGFb_propeptide; TGF-beta propeptide

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049298.1 Alternate UMICH_Zoey_3.1

    Range
    13473487..13553481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038522359.1 → XP_038378287.1  transforming growth factor beta-2 proprotein isoform X3

    Conserved Domains (1) summary
    pfam00688
    Location:21 → 256
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038522357.1 → XP_038378285.1  transforming growth factor beta-2 proprotein isoform X1

    Conserved Domains (2) summary
    cd19385
    Location:345 → 441
    TGF_beta_TGFB2; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins
    pfam00688
    Location:21 → 256
    TGFb_propeptide; TGF-beta propeptide

  3. XM_038522358.1 → XP_038378286.1  transforming growth factor beta-2 proprotein isoform X2

    Conserved Domains (2) summary
    cd19385
    Location:317 → 413
    TGF_beta_TGFB2; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins
    pfam00688
    Location:21 → 228
    TGFb_propeptide; TGF-beta propeptide

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049779.1 Alternate UNSW_CanFamBas_1.0

    Range
    13819811..13899809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038650566.1 → XP_038506494.1  transforming growth factor beta-2 proprotein isoform X3

    Conserved Domains (1) summary
    pfam00688
    Location:21 → 256
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038650564.1 → XP_038506492.1  transforming growth factor beta-2 proprotein isoform X1

    Conserved Domains (2) summary
    cd19385
    Location:345 → 441
    TGF_beta_TGFB2; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins
    pfam00688
    Location:21 → 256
    TGFb_propeptide; TGF-beta propeptide

  3. XM_038650565.1 → XP_038506493.1  transforming growth factor beta-2 proprotein isoform X2

    Conserved Domains (2) summary
    cd19385
    Location:317 → 413
    TGF_beta_TGFB2; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins
    pfam00688
    Location:21 → 228
    TGFb_propeptide; TGF-beta propeptide

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049259.1 Alternate UU_Cfam_GSD_1.0

    Range
    14128921..14209014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038586163.1 → XP_038442091.1  transforming growth factor beta-2 proprotein isoform X3

    Conserved Domains (1) summary
    pfam00688
    Location:21 → 256
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038586161.1 → XP_038442089.1  transforming growth factor beta-2 proprotein isoform X1

    UniProtKB/TrEMBL
    A0A8C0P803, A0A8I3PZZ6, A0A8I3QKA5, A0A8P0P1R2
    Conserved Domains (2) summary
    cd19385
    Location:345 → 441
    TGF_beta_TGFB2; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins
    pfam00688
    Location:21 → 256
    TGFb_propeptide; TGF-beta propeptide

  3. XM_038586162.1 → XP_038442090.1  transforming growth factor beta-2 proprotein isoform X2

    UniProtKB/TrEMBL
    A0A8C0JSS2, A0A8C0RRP5, A0A8I3QKA5, A0A8P0P1R2
    Conserved Domains (2) summary
    cd19385
    Location:317 → 413
    TGF_beta_TGFB2; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins
    pfam00688
    Location:21 → 228
    TGFb_propeptide; TGF-beta propeptide

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006620.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    13472728..13552654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005640824.3 → XP_005640881.1  transforming growth factor beta-2 proprotein isoform X3

    Conserved Domains (1) summary
    pfam00688
    Location:21 → 256
    TGFb_propeptide; TGF-beta propeptide

  2. XM_545713.7 → XP_545713.2  transforming growth factor beta-2 proprotein isoform X1

    UniProtKB/TrEMBL
    A0A8C0P803, A0A8I3PZZ6, A0A8I3QKA5, A0A8P0P1R2
    Conserved Domains (2) summary
    cd19385
    Location:345 → 441
    TGF_beta_TGFB2; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins
    pfam00688
    Location:21 → 256
    TGFb_propeptide; TGF-beta propeptide

  3. XM_853584.6 → XP_858677.1  transforming growth factor beta-2 proprotein isoform X2

    See identical proteins and their annotated locations for XP_858677.1

    UniProtKB/TrEMBL
    A0A8C0JSS2, A0A8C0RRP5, A0A8I3QKA5, A0A8P0P1R2
    Conserved Domains (2) summary
    cd19385
    Location:317 → 413
    TGF_beta_TGFB2; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins
    pfam00688
    Location:21 → 228
    TGFb_propeptide; TGF-beta propeptide
Nucleotide Protein
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