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CG5504 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48844, updated on 2-Nov-2024

Summary

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Official Symbol
CG5504provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0002174
Locus tag
Dmel_CG5504
See related
AllianceGenome:FB:FBgn0002174
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cDNA 10D; Dmel\CG5504; DnaJ; l(2)701; l(2)tid; l(2)tud; lethal (2) tumorous imaginal discs; TID56
Summary
Enables patched binding activity. Involved in negative regulation of smoothened signaling pathway. Located in cytosol and mitochondrion. Is expressed in several structures, including adult head; embryonic Malpighian tubule tip cell; embryonic/larval midgut primordium; gut section; and larval muscle cell. Orthologous to human DNAJA3 (DnaJ heat shock protein family (Hsp40) member A3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See CG5504 in Genome Data Viewer
Location:
59F6-59F6; 2-104 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23706913..23709026)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19594436..19596549)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene salivary glands marred Neighboring gene lethal-(2)-denticleless Neighboring gene antisense RNA:CR45326 Neighboring gene ALG3, alpha-1,3- mannosyltransferase Neighboring gene uncharacterized protein Neighboring gene Sestrin Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tumor suppression in Drosophila is causally related to the function of the lethal(2) tumorous imaginal discs gene, a dnaJ homolog. Kurzik-Dumke U, et al. Dev Genet, 1995. PMID 7758246
  2. Gene within gene configuration and expression of the Drosophila melanogaster genes lethal(2) neighbour of tid [l(2)not] and lethal(2) relative of tid[l(2)rot]. Kurzik-Dumke U, et al. Gene, 1997 Oct 24. PMID 9373138
  3. Mitochondrial localization and temporal expression of the Drosophila melanogaster DnaJ homologous tumor suppressor Tid50. Kurzik-Dumke U, et al. Cell Stress Chaperones, 1998 Mar. PMID 9585178, Free PMC Article
  4. Sequence of the new Drosophila melanogaster small heat-shock-related gene, lethal(2) essential for life [l(2)efl], at locus 59F4,5. Kurzik-Dumke U, et al. Gene, 1995 Mar 10. PMID 7890160
  5. Identification of a novel Drosophila melanogaster heat-shock gene, lethal(2)denticleless [l(2)dtl], coding for an 83-kDa protein. Kurzik-Dumke U, et al. Gene, 1996 Jun 1. PMID 8666267

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
  
enables patched binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG5504-PA
CG5504-PB
CG5504-PC
CG5504-PD
CG5504-PE
lethal (2) tumorous imaginal discs
lethal(2) tumorous imaginal discs
lethal(2)tumorous imaginal discs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23706913..23709026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206209.3 → NP_995931.1  uncharacterized protein Dmel_CG5504, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995931.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D6W4V2, Q7KVH7
    Conserved Domains (4) summary
    cd10719
    Location:227 → 287
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:288 → 409
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:63 → 437
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:65 → 127
    DnaJ; DnaJ domain

  2. NM_206210.3 → NP_995932.1  uncharacterized protein Dmel_CG5504, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995932.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02528, O02529, O02549, Q24554, Q27237, Q27259, Q7KVH8, Q8T9A7, Q9W1K7
    UniProtKB/TrEMBL
    A0A0F7J3E9
    Conserved Domains (4) summary
    cd10719
    Location:227 → 287
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:288 → 409
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:63 → 437
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:65 → 127
    DnaJ; DnaJ domain

  3. NM_080193.5 → NP_524932.2  uncharacterized protein Dmel_CG5504, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524932.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D6W4V2
    Related
    FBpp0088498
    Conserved Domains (4) summary
    cd10719
    Location:227 → 287
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:288 → 409
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:63 → 437
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:65 → 127
    DnaJ; DnaJ domain

  4. NM_001259554.2 → NP_001246483.1  uncharacterized protein Dmel_CG5504, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246483.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7M9, T2GGE7
    Conserved Domains (4) summary
    cd10719
    Location:227 → 287
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:288 → 409
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:63 → 437
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:65 → 127
    DnaJ; DnaJ domain

  5. NM_001299848.1 → NP_001286777.1  uncharacterized protein Dmel_CG5504, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286777.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DN23, D6W4V2
    Conserved Domains (4) summary
    cd10719
    Location:227 → 287
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:288 → 409
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:63 → 437
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:65 → 127
    DnaJ; DnaJ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7M9 A0A0B4K7M9
D3DN23 D3DN23
Q27237.2 Q27237
Q7KVH7 Q7KVH7

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