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ECT2 epithelial cell transforming 2 [ Canis lupus familiaris (dog) ]

Gene ID: 488172, updated on 17-Aug-2024

Summary

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Official Symbol
ECT2provided by VGNC
Official Full Name
epithelial cell transforming 2provided by VGNC
Primary source
VGNC:VGNC:40189
See related
Ensembl:ENSCAFG00845025956
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ECT2 in Genome Data Viewer
Location:
chromosome: 34
Exon count:
27
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 34 NC_051838.1 (36981676..37043349)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 34 NC_006616.4 (45907851..45969821)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 34 NC_049255.1 (37146019..37207403)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 34 NC_049294.1 (36919236..36980903)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 34 NC_049775.1 (36888783..36950259)

Chromosome 34 - NC_051838.1Genomic Context describing neighboring genes Neighboring gene TNF superfamily member 10 Neighboring gene uncharacterized LOC119867533 Neighboring gene neutral cholesterol ester hydrolase 1 Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase subunit P-like Neighboring gene T-complex protein 1 subunit eta Neighboring gene spermatogenesis associated 16 Neighboring gene uncharacterized LOC111093953

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide exchange factor ECT2 regulates epithelial cell polarity. Liu XF, et al. Cell Signal, 2006 Oct. PMID 16495035
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ECT2 appears to play a critical role in epithelial cell polarity.
    Title: Nucleotide exchange factor ECT2 regulates epithelial cell polarity.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cytokinesis, actomyosin contractile ring assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein ECT2
Names
epithelial cell transforming sequence 2 oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051838.1 Reference ROS_Cfam_1.0

    Range
    36981676..37043349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038446093.1 → XP_038302021.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKF5, A0A8I3PQ90, A0A8I3PSD4, A0A8P0T0H6, A0A8P0T2B2
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  2. XM_038446092.1 → XP_038302020.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKF5, A0A8I3PQ90, A0A8I3PSD4, A0A8P0T0H6, A0A8P0T2B2
    Related
    ENSCAFP00845036206.1, ENSCAFT00845046113.1
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  3. XM_038446098.1 → XP_038302026.1  protein ECT2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0RT98, A0A8C0SQ33, A0A8I3PSY2
    Related
    ENSCAFP00845035973.1, ENSCAFT00845045822.1
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  4. XM_038446097.1 → XP_038302025.1  protein ECT2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0SPV8
    Conserved Domains (4) summary
    cd01229
    Location:591 → 764
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    pfam00621
    Location:456 → 599
    RhoGEF; RhoGEF domain

  5. XM_038446095.1 → XP_038302023.1  protein ECT2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0PKF5, A0A8I3PQ90, A0A8P0T2B2
    Conserved Domains (4) summary
    smart00325
    Location:427 → 611
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:602 → 775
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  6. XM_038446100.1 → XP_038302028.1  protein ECT2 isoform X7

    UniProtKB/TrEMBL
    A0A8I3PPV1, A0A8P0SSE8
    Conserved Domains (4) summary
    smart00325
    Location:396 → 580
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:571 → 744
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  7. XM_038446096.1 → XP_038302024.1  protein ECT2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0RT69
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  8. XM_038446099.1 → XP_038302027.1  protein ECT2 isoform X6

    UniProtKB/TrEMBL
    A0A8I3PPV1, A0A8P0SSE8
    Related
    ENSCAFP00845036742.1, ENSCAFT00845046848.1
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  9. XM_038446094.1 → XP_038302022.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKF5, A0A8I3PQ90, A0A8I3PSD4, A0A8P0T0H6, A0A8P0T2B2
    Related
    ENSCAFP00845036906.1, ENSCAFT00845047031.1
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049294.1 Alternate UMICH_Zoey_3.1

    Range
    36919236..36980903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038520276.1 → XP_038376204.1  protein ECT2 isoform X1

  2. XM_038520275.1 → XP_038376203.1  protein ECT2 isoform X1

  3. XM_038520281.1 → XP_038376209.1  protein ECT2 isoform X5

    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  4. XM_038520280.1 → XP_038376208.1  protein ECT2 isoform X4

  5. XM_038520278.1 → XP_038376206.1  protein ECT2 isoform X2

  6. XM_038520283.1 → XP_038376211.1  protein ECT2 isoform X7

    Conserved Domains (4) summary
    smart00325
    Location:396 → 580
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:571 → 744
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  7. XM_038520279.1 → XP_038376207.1  protein ECT2 isoform X3

  8. XM_038520282.1 → XP_038376210.1  protein ECT2 isoform X6

    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  9. XM_038520277.1 → XP_038376205.1  protein ECT2 isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049775.1 Alternate UNSW_CanFamBas_1.0

    Range
    36888783..36950259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038648325.1 → XP_038504253.1  protein ECT2 isoform X1

    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  2. XM_038648331.1 → XP_038504259.1  protein ECT2 isoform X5

    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  3. XM_038648330.1 → XP_038504258.1  protein ECT2 isoform X4

    Conserved Domains (4) summary
    cd01229
    Location:591 → 764
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    pfam00621
    Location:456 → 599
    RhoGEF; RhoGEF domain

  4. XM_038648328.1 → XP_038504256.1  protein ECT2 isoform X2

    Conserved Domains (4) summary
    smart00325
    Location:427 → 611
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:602 → 775
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  5. XM_038648333.1 → XP_038504261.1  protein ECT2 isoform X7

    Conserved Domains (4) summary
    smart00325
    Location:396 → 580
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:571 → 744
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  6. XM_038648329.1 → XP_038504257.1  protein ECT2 isoform X3

    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  7. XM_038648332.1 → XP_038504260.1  protein ECT2 isoform X6

    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  8. XM_038648326.1 → XP_038504254.1  protein ECT2 isoform X1

    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  9. XM_038648327.1 → XP_038504255.1  protein ECT2 isoform X1

    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049255.1 Alternate UU_Cfam_GSD_1.0

    Range
    37146019..37207403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038583911.1 → XP_038439839.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKF5, A0A8I3PQ90, A0A8I3PSD4, A0A8P0T0H6, A0A8P0T2B2
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  2. XM_038583910.1 → XP_038439838.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKF5, A0A8I3PQ90, A0A8I3PSD4, A0A8P0T0H6, A0A8P0T2B2
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  3. XM_038583916.1 → XP_038439844.1  protein ECT2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0RT98, A0A8C0SQ33, A0A8I3PSY2
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  4. XM_038583915.1 → XP_038439843.1  protein ECT2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0SPV8
    Conserved Domains (4) summary
    cd01229
    Location:591 → 764
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    pfam00621
    Location:456 → 599
    RhoGEF; RhoGEF domain

  5. XM_038583913.1 → XP_038439841.1  protein ECT2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0PKF5, A0A8I3PQ90, A0A8P0T2B2
    Conserved Domains (4) summary
    smart00325
    Location:427 → 611
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:602 → 775
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  6. XM_038583918.1 → XP_038439846.1  protein ECT2 isoform X7

    UniProtKB/TrEMBL
    A0A8I3PPV1, A0A8P0SSE8
    Conserved Domains (4) summary
    smart00325
    Location:396 → 580
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:571 → 744
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  7. XM_038583914.1 → XP_038439842.1  protein ECT2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0RT69
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  8. XM_038583917.1 → XP_038439845.1  protein ECT2 isoform X6

    UniProtKB/TrEMBL
    A0A8I3PPV1, A0A8P0SSE8
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  9. XM_038583912.1 → XP_038439840.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKF5, A0A8I3PQ90, A0A8I3PSD4, A0A8P0T0H6, A0A8P0T2B2
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006616.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    45907851..45969821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038462838.1 → XP_038318766.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKF5, A0A8I3PQ90, A0A8I3PSD4, A0A8P0T0H6, A0A8P0T2B2
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  2. XM_038462837.1 → XP_038318765.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKF5, A0A8I3PQ90, A0A8I3PSD4, A0A8P0T0H6, A0A8P0T2B2
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  3. XM_038462842.1 → XP_038318770.1  protein ECT2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0RT98, A0A8C0SQ33, A0A8I3PSY2
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  4. XM_038462841.1 → XP_038318769.1  protein ECT2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0SPV8
    Conserved Domains (4) summary
    cd01229
    Location:591 → 764
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    pfam00621
    Location:456 → 599
    RhoGEF; RhoGEF domain

  5. XM_038462839.1 → XP_038318767.1  protein ECT2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0PKF5, A0A8I3PQ90, A0A8P0T2B2
    Conserved Domains (4) summary
    smart00325
    Location:427 → 611
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:602 → 775
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  6. XM_038462845.1 → XP_038318773.1  protein ECT2 isoform X7

    UniProtKB/TrEMBL
    A0A8I3PPV1, A0A8P0SSE8
    Conserved Domains (4) summary
    smart00325
    Location:396 → 580
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:571 → 744
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  7. XM_038462840.1 → XP_038318768.1  protein ECT2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0RT69
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  8. XM_038462843.1 → XP_038318771.1  protein ECT2 isoform X6

    UniProtKB/TrEMBL
    A0A8I3PPV1, A0A8P0SSE8
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  9. XM_014110472.3 → XP_013965947.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKF5, A0A8I3PQ90, A0A8I3PSD4, A0A8P0T0H6, A0A8P0T2B2
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
Nucleotide Protein
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