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THBS1 thrombospondin 1 [ Canis lupus familiaris (dog) ]

Gene ID: 487486, updated on 17-Aug-2024

Summary

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Official Symbol
THBS1provided by VGNC
Official Full Name
thrombospondin 1provided by VGNC
Primary source
VGNC:VGNC:47335
See related
Ensembl:ENSCAFG00845026582
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See THBS1 in Genome Data Viewer
Location:
chromosome: 30
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (6896290..6912963)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (6824809..6841468)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (7055241..7071904)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (6820232..6836894)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (6926083..6942777)

Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102155895 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102155568 Neighboring gene fibrous sheath interacting protein 1 Neighboring gene U6 spliceosomal RNA Neighboring gene G protein-coupled receptor 176 Neighboring gene uncharacterized LOC111093307 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Light-activated BioID - an optically activated proximity labeling system to study protein-protein interactions. Shafraz O, et al. J Cell Sci, 2023 Oct 1. PMID 37756605, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
thrombospondin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051834.1 Reference ROS_Cfam_1.0

    Range
    6896290..6912963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038441944.1 → XP_038297872.1  thrombospondin-1

    UniProtKB/TrEMBL
    A0A8C0RTE6
    Related
    ENSCAFP00845036749.1, ENSCAFT00845046857.1
    Conserved Domains (11) summary
    smart00209
    Location:438 → 490
    TSP1; Thrombospondin type 1 repeats
    smart00210
    Location:26 → 221
    TSPN; Thrombospondin N-terminal -like domains
    sd00001
    Location:845 → 882
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:787 → 821
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:691 → 726
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam00093
    Location:318 → 372
    VWC; von Willebrand factor type C domain
    pfam02412
    Location:846 → 882
    TSP_3; Thrombospondin type 3 repeat
    pfam00090
    Location:383 → 428
    TSP_1; Thrombospondin type 1 domain
    pfam05735
    Location:972 → 1169
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:650 → 689
    EGF_3; EGF domain
    NF033609
    Location:692 → 976
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049290.1 Alternate UMICH_Zoey_3.1

    Range
    6820232..6836894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038516426.1 → XP_038372354.1  thrombospondin-1

    Conserved Domains (11) summary
    smart00209
    Location:438 → 490
    TSP1; Thrombospondin type 1 repeats
    smart00210
    Location:26 → 221
    TSPN; Thrombospondin N-terminal -like domains
    sd00001
    Location:845 → 882
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:787 → 821
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:691 → 726
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam00093
    Location:318 → 372
    VWC; von Willebrand factor type C domain
    pfam02412
    Location:846 → 882
    TSP_3; Thrombospondin type 3 repeat
    pfam00090
    Location:383 → 428
    TSP_1; Thrombospondin type 1 domain
    pfam05735
    Location:972 → 1169
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:650 → 689
    EGF_3; EGF domain
    NF033609
    Location:692 → 976
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

    Range
    6926083..6942777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038644289.1 → XP_038500217.1  thrombospondin-1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

    Range
    7055241..7071904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038580015.1 → XP_038435943.1  thrombospondin-1

    UniProtKB/TrEMBL
    A0A8C0RTE6
    Conserved Domains (11) summary
    smart00209
    Location:438 → 490
    TSP1; Thrombospondin type 1 repeats
    smart00210
    Location:26 → 221
    TSPN; Thrombospondin N-terminal -like domains
    sd00001
    Location:845 → 882
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:787 → 821
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:691 → 726
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam00093
    Location:318 → 372
    VWC; von Willebrand factor type C domain
    pfam02412
    Location:846 → 882
    TSP_3; Thrombospondin type 3 repeat
    pfam00090
    Location:383 → 428
    TSP_1; Thrombospondin type 1 domain
    pfam05735
    Location:972 → 1169
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:650 → 689
    EGF_3; EGF domain
    NF033609
    Location:692 → 976
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    6824809..6841468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_544610.7 → XP_544610.3  thrombospondin-1

    UniProtKB/TrEMBL
    A0A8C0RTE6
    Conserved Domains (11) summary
    smart00209
    Location:438 → 490
    TSP1; Thrombospondin type 1 repeats
    smart00210
    Location:26 → 221
    TSPN; Thrombospondin N-terminal -like domains
    sd00001
    Location:845 → 882
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:787 → 821
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:691 → 726
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam00093
    Location:318 → 372
    VWC; von Willebrand factor type C domain
    pfam02412
    Location:846 → 882
    TSP_3; Thrombospondin type 3 repeat
    pfam00090
    Location:383 → 428
    TSP_1; Thrombospondin type 1 domain
    pfam05735
    Location:972 → 1169
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:650 → 689
    EGF_3; EGF domain
    NF033609
    Location:692 → 976
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
Nucleotide Protein
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