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NPPB natriuretic peptide B [ Canis lupus familiaris (dog) ]

Gene ID: 487441, updated on 17-Aug-2024

Summary

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Official Symbol
NPPBprovided by VGNC
Official Full Name
natriuretic peptide Bprovided by VGNC
Primary source
VGNC:VGNC:43926
See related
Ensembl:ENSCAFG00845001994
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
BNP; Iso-ANP
Orthologs
human mouse all
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Genomic context

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See NPPB in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (85060368..85062010)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (80929289..80930932)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (83872280..83873924)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (81809597..81811239)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (82809514..82811156)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene KIAA2013 Neighboring gene U5 spliceosomal RNA Neighboring gene natriuretic peptide A Neighboring gene chloride voltage-gated channel 6 Neighboring gene methylenetetrahydrofolate reductase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Resting and dobutamine stress test induced serum concentrations of brain natriuretic peptide in German Shepherd dogs. Spasojević Kosić L, et al. Res Vet Sci, 2012 Dec. PMID 22537461
  2. Evaluation of plasma N-terminal pro-B-type natriuretic peptide concentrations in dogs with and without cardiac disease. Ettinger SJ, et al. J Am Vet Med Assoc, 2012 Jan 15. PMID 22217025
  3. The cardiac biomarker NT-proBNP is increased in dogs with azotemia. Raffan E, et al. J Vet Intern Med, 2009 Nov-Dec. PMID 19709357
  4. Evaluation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in dogs with mitral valve insufficiency. Takemura N, et al. J Vet Med Sci, 2009 Jul. PMID 19652480
  5. Canine heterophilic antibodies as a source of false-positive B-type natriuretic peptide sandwich ELISA results. Solter PF, et al. Vet Clin Pathol, 2008 Mar. PMID 18366550

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results indicated that plasma atrial natriuretic peptide and natriuretic peptide precursor B (NT-proBNP) responded to severe, but not mild, pulmonary arterial hypertension
    Title: Diagnostic utility of NT-proBNP and ANP in a canine model of chronic embolic pulmonary hypertension.
  2. These data suggest that BNP is not increased in aged dogs with normal cardiac systolic function and renal function, and that myocardial ischemia leads to a significant increase in BNP concentrations even in dogs with normal left ventricular function.
    Title: Resting and dobutamine stress test induced serum concentrations of brain natriuretic peptide in German Shepherd dogs.
  3. The use of NT-pro-BNP and troponin I levels as prognostic indicators for canine heart failure is reported.
    Title: NT-pro-BNP and troponin I as predictors of mortality in dogs with heart failure.
  4. Mean NT-proBNP concentration was significantly increased in dogs with cardiac-related dyspnea or coughing, compared with dogs in which these signs were noncardiac related.
    Title: Evaluation of plasma N-terminal pro-B-type natriuretic peptide concentrations in dogs with and without cardiac disease.
  5. [NT-proBNP] concentration is significantly higher in dogs with pre-capillary pulmonary hypertension (PH) when compared to dogs with respiratory disease without PH; [NT-proANP] and [cTnI] were not elevated in dogs with pre-capillary PH.
    Title: NT-proBNP, NT-proANP and cTnI concentrations in dogs with pre-capillary pulmonary hypertension.
  6. Azotemia results in NT-proBNP being increased to concentrations reported as diagnostic of heart disease or heart failure in dogs.
    Title: The cardiac biomarker NT-proBNP is increased in dogs with azotemia.
  7. The use of Plasma atrial natriuretic peptide (proANP 31-67), B-type natriuretic peptide (Nt-proBNP) and endothelin-1 (ET-1) concentrations as disease markers in dogs with valvular heart disease is reported.[proANP; NT-proBNP]
    Title: Plasma atrial natriuretic peptide (proANP 31-67), B-type natriuretic peptide (Nt-proBNP) and endothelin-1 (ET-1) concentrations in dogs with chronic degenerative valvular disease (CDVD).
  8. These findings could indicate that plasma NT-proBNP concentration was significantly associated with the severity of heart failure due to mitral valve insufficiency in dogs.
    Title: Evaluation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in dogs with mitral valve insufficiency.
  9. Intrapericardial endothelin-1 did not alter pericardial BNP levels.
    Title: Effects of intrapericardially administered endothelin-1 on pericardial natriuretic peptide concentrations of the in situ dog heart.
  10. differential regulation of gene expression of cardiotrophin-1 and BNP in the heart during the progression of congestive heart failure; ventricular CT-1 gene activation precedes ventricular BNP gene activation [brain natriuretic peptide=BNP]
    Title: Ventricular cardiotrophin-1 activation precedes BNP in experimental heart failure.
Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor guanylyl cyclase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
natriuretic peptides B
Names
Gamma-brain natriuretic peptide
Natriuretic peptides B
brain natriuretic factor prohormone
brain natriuretic peptide
natriuretic peptide precursor B
preproBNP
proBNP

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    85060368..85062010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038657971.1 → XP_038513899.1  natriuretic peptides B

    UniProtKB/Swiss-Prot
    P16859
    UniProtKB/TrEMBL
    A0A8I3MHJ9
    Related
    ENSCAFP00845002768.1, ENSCAFT00845003490.1
    Conserved Domains (1) summary
    pfam00212
    Location:105 → 135
    ANP; Atrial natriuretic peptide

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    81809597..81811239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038468934.1 → XP_038324862.1  natriuretic peptides B

    Conserved Domains (1) summary
    pfam00212
    Location:105 → 135
    ANP; Atrial natriuretic peptide

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    82809514..82811156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038593894.1 → XP_038449822.1  natriuretic peptides B

    Conserved Domains (1) summary
    pfam00212
    Location:105 → 135
    ANP; Atrial natriuretic peptide

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    83872280..83873924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038529657.1 → XP_038385585.1  natriuretic peptides B

    UniProtKB/Swiss-Prot
    P16859
    UniProtKB/TrEMBL
    A0A8I3MHJ9
    Conserved Domains (1) summary
    pfam00212
    Location:105 → 135
    ANP; Atrial natriuretic peptide

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    80929289..80930932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014111456.3 → XP_013966931.1  natriuretic peptides B

    UniProtKB/Swiss-Prot
    P16859
    UniProtKB/TrEMBL
    A0A8P0PRD3
    Conserved Domains (1) summary
    pfam00212
    Location:105 → 135
    ANP; Atrial natriuretic peptide
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16859.1 GenPept UniProtKB/Swiss-Prot:P16859

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