IGF2R insulin like growth factor 2 receptor [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: IGF2Rprovided by VGNC
Official Full Name: insulin like growth factor 2 receptorprovided by VGNC
Primary source: VGNC:VGNC:41901
See related: Ensembl:ENSCAFG00845002089
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (49345406..49445163)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (50002759..50102366)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (49714384..49814084)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (49227935..49327529)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (49099537..49199165)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using bisulfite sequencing, study shows that the canine IGF2R resembles the imprinted mouse Igf2r in having a CpG island in intron 2 that is hemi-methylated
Title: Imprinted expression of the canine IGF2R, in the absence of an anti-sense transcript or promoter methylation.

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General gene information

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Markers

PMC23366P7 (e-PCR)
- UniSTS:272201

RH35870 (e-PCR)
- UniSTS:15450

GDB:186982 (e-PCR)
- UniSTS:155526

D1S3690 (e-PCR)
- UniSTS:474268

GDB:196396 (e-PCR)
- UniSTS:155848

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables D-mannose binding	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin-like growth factor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in lysosomal transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in late endosome	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cation-independent mannose-6-phosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122602.1 → NP_001116074.1 cation-independent mannose-6-phosphate receptor precursor

See identical proteins and their annotated locations for NP_001116074.1

Status: PROVISIONAL

Source sequence(s)

AY965264

UniProtKB/TrEMBL

A0A8C0L291, A0A8C0N2Z9, A0A8C0TKB8, A0A8P0NNR9, B1H0W0

Related

ENSCAFP00845002896.1, ENSCAFT00845003644.1

Conserved Domains (3) summary

smart00059
Location:1901 → 1946

FN2; Fibronectin type 2 domain

pfam00878
Location:1039 → 1182

CIMR; Cation-independent mannose-6-phosphate receptor repeat

cl26634
Location:1230 → 1366

ATG27; Autophagy-related protein 27