INS insulin [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: INSprovided by VGNC
Official Full Name: insulinprovided by VGNC
Primary source: VGNC:VGNC:97204
See related: Ensembl:ENSCAFG00845011141
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	18	NC_051822.1 (47003520..47004406, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	18	NC_006600.4 (44933843..44934720, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	18	NC_049239.1 (46779045..46779926, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	18	NC_049278.1 (46452280..46453156, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	18	NC_049759.1 (46032597..46033483, complement)

Chromosome 18 - NC_051822.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The etiology of blindness in dogs with pituitary dependent hypercortisolism, including the role of adiponectin, interleukin 6, insulin, and nitric oxide, is reported.
Title: Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism.
Gluconeogenic flux can be rapidly inhibited by high insulin levels in canines.
Title: Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo.

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General gene information

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Markers

Ins1 (e-PCR), detects polymorphism
- UniSTS:256685

Ins2 (e-PCR), detects polymorphism
- UniSTS:259556

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130093.2 → NP_001123565.1 insulin precursor

See identical proteins and their annotated locations for NP_001123565.1

Status: PROVISIONAL

Source sequence(s)

JAAUVH010000176

UniProtKB/Swiss-Prot

P01321

UniProtKB/TrEMBL

A0A8C0NTT6, A0A8C0R307

Related

ENSCAFP00845015468.1, ENSCAFT00845019762.1

Conserved Domains (1) summary

cd04367
Location:26 → 110

IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...