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SPHK1 sphingosine kinase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 483329, updated on 17-Aug-2024

Summary

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Official Symbol
SPHK1provided by VGNC
Official Full Name
sphingosine kinase 1provided by VGNC
Primary source
VGNC:VGNC:49655
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See SPHK1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (4984498..4988116, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (4992955..4996576, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (5213806..5217418, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (5012727..5016344, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (5132520..5136143, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097290 Neighboring gene ubiquitin conjugating enzyme E2 O Neighboring gene uncharacterized LOC106559235 Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection. Seo YJ, et al. PLoS One, 2013. PMID 24137500, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SK is a key pro-viral factor regulating multiple cellular signal pathways triggered by influenza virus infection
    Title: Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables D-erythro-sphingosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sphingosine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sphingosine kinase 1
XP_038343483.1
XP_038405414.1
XP_038469344.1
XP_038477950.1
XP_038531200.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    4984498..4988116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038675272.1 → XP_038531200.1  sphingosine kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3S0D0
    Conserved Domains (2) summary
    PLN02958
    Location:221 → 558
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
    PHA03247
    Location:8 → 144
    PHA03247; large tegument protein UL36; Provisional

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    5012727..5016344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038487555.1 → XP_038343483.1  sphingosine kinase 1 isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    5132520..5136143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038613416.1 → XP_038469344.1  sphingosine kinase 1 isoform X1

    Conserved Domains (2) summary
    PLN02958
    Location:221 → 558
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
    PHA03247
    Location:8 → 144
    PHA03247; large tegument protein UL36; Provisional

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    5213806..5217418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038549486.1 → XP_038405414.1  sphingosine kinase 1 isoform X3

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    4992955..4996576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038622022.1 → XP_038477950.1  sphingosine kinase 1 isoform X4

    Conserved Domains (2) summary
    PLN02958
    Location:242 → 579
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
    PRK07003
    Location:8 → 243
    PRK07003; DNA polymerase III subunit gamma/tau
Nucleotide Protein
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