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SESN1 sestrin 1 [ Canis lupus familiaris (dog) ]

Gene ID: 481956, updated on 17-Aug-2024

Summary

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Official Symbol
SESN1provided by VGNC
Official Full Name
sestrin 1provided by VGNC
Primary source
VGNC:VGNC:46047
See related
Ensembl:ENSCAFG00845009981
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See SESN1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (66840480..66939046, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (65777446..65875811, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (66311345..66409780, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (66191015..66289363, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (66039317..66137542, complement)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 2 Neighboring gene uncharacterized LOC111098388 Neighboring gene uncharacterized LOC111098386 Neighboring gene uncharacterized LOC111098391 Neighboring gene centrosomal protein 57 like 1 Neighboring gene ubiquitin-conjugating enzyme E2 D3-like Neighboring gene uncharacterized LOC612235

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables L-leucine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity, acting on peroxide as acceptor IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to L-leucine IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to leucine starvation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of response to reactive oxygen species IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sestrin-1
XP_038348500.1
XP_038348501.1
XP_038410813.1
XP_038410814.1
XP_038474687.1
XP_038474689.1
XP_038540249.1
XP_038540250.1
XP_539077.2
XP_854341.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    66840480..66939046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038684321.1 → XP_038540249.1  sestrin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R3A7, A0A8C0S7I6, A0A8C0S8D1, A0A8I3NDQ5, A0A8I3NPY4
    Related
    ENSCAFP00845013669.1, ENSCAFT00845017560.1
    Conserved Domains (1) summary
    pfam04636
    Location:107 → 551
    PA26; PA26 p53-induced protein (sestrin)

  2. XM_038684322.1 → XP_038540250.1  sestrin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KZN5, A0A8C0N521, A0A8P0P2T2
    Conserved Domains (1) summary
    pfam04636
    Location:47 → 491
    PA26; PA26 p53-induced protein (sestrin)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    66191015..66289363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038492572.1 → XP_038348500.1  sestrin-1 isoform X1

    Conserved Domains (1) summary
    pfam04636
    Location:107 → 551
    PA26; PA26 p53-induced protein (sestrin)

  2. XM_038492573.1 → XP_038348501.1  sestrin-1 isoform X2

    Conserved Domains (1) summary
    pfam04636
    Location:47 → 491
    PA26; PA26 p53-induced protein (sestrin)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    66039317..66137542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038618759.1 → XP_038474687.1  sestrin-1 isoform X1

    Conserved Domains (1) summary
    pfam04636
    Location:107 → 551
    PA26; PA26 p53-induced protein (sestrin)

  2. XM_038618761.1 → XP_038474689.1  sestrin-1 isoform X2

    Conserved Domains (1) summary
    pfam04636
    Location:47 → 491
    PA26; PA26 p53-induced protein (sestrin)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    66311345..66409780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038554885.1 → XP_038410813.1  sestrin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R3A7, A0A8C0S7I6, A0A8C0S8D1, A0A8I3NDQ5, A0A8I3NPY4
    Conserved Domains (1) summary
    pfam04636
    Location:107 → 551
    PA26; PA26 p53-induced protein (sestrin)

  2. XM_038554886.1 → XP_038410814.1  sestrin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KZN5, A0A8C0N521, A0A8P0P2T2
    Conserved Domains (1) summary
    pfam04636
    Location:47 → 491
    PA26; PA26 p53-induced protein (sestrin)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    65777446..65875811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_849248.6 → XP_854341.1  sestrin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R3A7, A0A8C0S7I6, A0A8C0S8D1, A0A8I3NDQ5, A0A8I3NPY4
    Conserved Domains (1) summary
    pfam04636
    Location:107 → 551
    PA26; PA26 p53-induced protein (sestrin)

  2. XM_539077.6 → XP_539077.2  sestrin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KZN5, A0A8C0N521, A0A8P0P2T2
    Conserved Domains (1) summary
    pfam04636
    Location:47 → 491
    PA26; PA26 p53-induced protein (sestrin)
Nucleotide Protein
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