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CDKN2B cyclin dependent kinase inhibitor 2B [ Canis lupus familiaris (dog) ]

Gene ID: 481563, updated on 5-Mar-2024

Summary

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Gene symbol
CDKN2B
Gene description
cyclin dependent kinase inhibitor 2B
See related
Ensembl:ENSCAFG00845016466
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
p15INK4B
Orthologs
human mouse all
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Genomic context

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See CDKN2B in Genome Data Viewer
Location:
chromosome: 11
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 11 NC_051815.1 (42165720..42207150, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 11 NC_006593.4 (39933406..39936568, complement) , (39895530..39924805, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 11 NC_049232.1 (41374892..41378057, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 11 NC_049271.1 (40873681..40876835, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 11 NC_049752.1 (40761542..40764705, complement) , (40723758..40752953, complement)

Chromosome 11 - NC_051815.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119873924 Neighboring gene methylthioadenosine phosphorylase Neighboring gene uncharacterized LOC111098066 Neighboring gene uncharacterized LOC119873925 Neighboring gene uncharacterized LOC102153066 Neighboring gene DMRT like family A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of chromosome 11 in canine fibrosarcomas highlights an unusual variability of CDKN2B in dogs. Aguirre-Hernández J, et al. BMC Vet Res, 2009 Jul 31. PMID 19643034, Free PMC Article
  2. Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-cell lymphoma. Fosmire SP, et al. Vet Pathol, 2007 Jul. PMID 17606508
  3. Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the CDKN2A/B Gene Locus as a Major Risk Locus. Letko A, et al. Genes (Basel), 2021 Dec 9. PMID 34946912, Free PMC Article
  4. Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Karlsson EK, et al. Genome Biol, 2013 Dec 12. PMID 24330828, Free PMC Article
  5. Simultaneous inactivation of the p16, p15 and p14 genes encoding cyclin-dependent kinase inhibitors in canine T-lymphoid tumor cells. Fujiwara-Igarashi A, et al. J Vet Med Sci, 2013. PMID 23343657

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the CDKN2A/B Gene Locus as a Major Risk Locus.
    Title: Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the CDKN2A/B Gene Locus as a Major Risk Locus.
  2. The greyhound locus exhibiting the strongest association, located 150 kilobases upstream of the genes CDKN2A/B, is also the most rearranged locus in canine osteosarcoma tumors.
    Title: Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B.
  3. In this study, the full-length complementary DNA (cDNA) of the canine p16 gene was cloned using the 5' and 3' rapid amplification of cDNA ends methods.
    Title: Simultaneous inactivation of the p16, p15 and p14 genes encoding cyclin-dependent kinase inhibitors in canine T-lymphoid tumor cells.
  4. BAC hybridisations on metaphases of two fibrosarcomas showed loss of heterozygosity on chromosome 11 in the CDKN2B-CDKN2A tumour suppressor gene cluster region
    Title: Disruption of chromosome 11 in canine fibrosarcomas highlights an unusual variability of CDKN2B in dogs.
  5. The data show that p16 deletion or inactivation occurs almost exclusively in high-grade T-cell non-Hodgkin's lymphoma(NHL); alternative pathways can generate functional phenotypes of Rb deficiency in low-grade T-cell NHL and in high-grade B-cell NHL.
    Title: Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-cell lymphoma.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cyclin-dependent kinase 4 inhibitor B
Names
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146269.1 → NP_001139741.1  cyclin-dependent kinase 4 inhibitor B

    Status: PROVISIONAL

    Source sequence(s)
    JAAUVH010000356
    UniProtKB/TrEMBL
    A0A8C0Q933
    Conserved Domains (2) summary
    COG0666
    Location:20 → 135
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:46 → 76
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051815.1 Reference ROS_Cfam_1.0

    Range
    42165720..42207150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038680960.1 → XP_038536888.1  cyclin-dependent kinase 4 inhibitor B isoform X1

    UniProtKB/TrEMBL
    K7YN73
    Related
    ENSCAFP00845023052.1, ENSCAFT00845029318.1
    Conserved Domains (2) summary
    COG0666
    Location:8 → 115
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:36 → 66
    ANK; ANK repeat [structural motif]

  2. XM_038680958.1 → XP_038536886.1  cyclin-dependent kinase 4 inhibitor B isoform X5

    UniProtKB/TrEMBL
    A0A8I3NWY9
    Related
    ENSCAFP00845022974.1, ENSCAFT00845029211.1
    Conserved Domains (2) summary
    COG0666
    Location:36 → 163
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:62 → 92
    ANK; ANK repeat [structural motif]

  3. XM_038680961.1 → XP_038536889.1  cyclin-dependent kinase 4 inhibitor B isoform X2

    Conserved Domains (2) summary
    COG0666
    Location:18 → 110
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:42 → 73
    ANK; ANK repeat [structural motif]

  4. XM_038680964.1 → XP_038536892.1  cyclin-dependent kinase 4 inhibitor B isoform X3

    Conserved Domains (2) summary
    COG0666
    Location:2 → 72
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:25 → 57
    ANK; ANK repeat [structural motif]

  5. XM_038680962.1 → XP_038536890.1  cyclin-dependent kinase 4 inhibitor B isoform X3

    Conserved Domains (2) summary
    COG0666
    Location:2 → 72
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:25 → 57
    ANK; ANK repeat [structural motif]

  6. XM_038680963.1 → XP_038536891.1  cyclin-dependent kinase 4 inhibitor B isoform X3

    Conserved Domains (2) summary
    COG0666
    Location:2 → 72
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:25 → 57
    ANK; ANK repeat [structural motif]

  7. XM_038680965.1 → XP_038536893.1  cyclin-dependent kinase 4 inhibitor B isoform X4

    UniProtKB/TrEMBL
    A0A8I3NR12
    Conserved Domains (2) summary
    COG0666
    Location:8 → 115
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:36 → 66
    ANK; ANK repeat [structural motif]

  8. XM_038680959.1 → XP_038536887.1  cyclin-dependent kinase 4 inhibitor B isoform X6

    UniProtKB/TrEMBL
    A0A8I3NWY9, A0A8P0TTM2, B7VGH0
    Related
    ENSCAFP00845023153.1, ENSCAFT00845029472.1
    Conserved Domains (2) summary
    COG0666
    Location:36 → 151
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:62 → 92
    ANK; ANK repeat [structural motif]

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049271.1 Alternate UMICH_Zoey_3.1

    Range
    40873681..40876835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049752.1 Alternate UNSW_CanFamBas_1.0

    Range
    40723758..40752953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

  2. NC_049752.1 Alternate UNSW_CanFamBas_1.0

    Range
    40761542..40764705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038616391.1 → XP_038472319.1  cyclin-dependent kinase 4 inhibitor B isoform X1

    Conserved Domains (2) summary
    COG0666
    Location:8 → 115
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:36 → 66
    ANK; ANK repeat [structural motif]

  2. XM_038616392.1 → XP_038472320.1  cyclin-dependent kinase 4 inhibitor B isoform X2

    Conserved Domains (2) summary
    COG0666
    Location:18 → 110
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:42 → 73
    ANK; ANK repeat [structural motif]

  3. XM_038616395.1 → XP_038472323.1  cyclin-dependent kinase 4 inhibitor B isoform X3

    Conserved Domains (2) summary
    COG0666
    Location:2 → 72
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:25 → 57
    ANK; ANK repeat [structural motif]

  4. XM_038616393.1 → XP_038472321.1  cyclin-dependent kinase 4 inhibitor B isoform X3

    Conserved Domains (2) summary
    COG0666
    Location:2 → 72
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:25 → 57
    ANK; ANK repeat [structural motif]

  5. XM_038616394.1 → XP_038472322.1  cyclin-dependent kinase 4 inhibitor B isoform X3

    Conserved Domains (2) summary
    COG0666
    Location:2 → 72
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:25 → 57
    ANK; ANK repeat [structural motif]

  6. XM_038616396.1 → XP_038472324.1  cyclin-dependent kinase 4 inhibitor B isoform X4

    Conserved Domains (2) summary
    COG0666
    Location:8 → 115
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:36 → 66
    ANK; ANK repeat [structural motif]

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049232.1 Alternate UU_Cfam_GSD_1.0

    Range
    41374892..41378057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006593.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    39895530..39924805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

  2. NC_006593.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    39933406..39936568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038659009.1 → XP_038514937.1  cyclin-dependent kinase 4 inhibitor B isoform X1

    UniProtKB/TrEMBL
    I6Q2X5, K7YN73
    Conserved Domains (2) summary
    COG0666
    Location:8 → 115
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:36 → 66
    ANK; ANK repeat [structural motif]

  2. XM_038659019.1 → XP_038514947.1  cyclin-dependent kinase 4 inhibitor B isoform X2

    Conserved Domains (2) summary
    COG0666
    Location:18 → 110
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:42 → 73
    ANK; ANK repeat [structural motif]

  3. XM_038659047.1 → XP_038514975.1  cyclin-dependent kinase 4 inhibitor B isoform X3

    Conserved Domains (2) summary
    COG0666
    Location:2 → 72
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:25 → 57
    ANK; ANK repeat [structural motif]

  4. XM_038659029.1 → XP_038514957.1  cyclin-dependent kinase 4 inhibitor B isoform X3

    Conserved Domains (2) summary
    COG0666
    Location:2 → 72
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:25 → 57
    ANK; ANK repeat [structural motif]

  5. XM_038659039.1 → XP_038514967.1  cyclin-dependent kinase 4 inhibitor B isoform X3

    Conserved Domains (2) summary
    COG0666
    Location:2 → 72
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:25 → 57
    ANK; ANK repeat [structural motif]

  6. XM_038659054.1 → XP_038514982.1  cyclin-dependent kinase 4 inhibitor B isoform X4

    UniProtKB/TrEMBL
    A0A8C0MZM8, A0A8P0TTY2
    Conserved Domains (2) summary
    COG0666
    Location:8 → 115
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:36 → 66
    ANK; ANK repeat [structural motif]
Nucleotide Protein
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