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Cbl E3 ubiquitin-protein ligase CBL [ Drosophila pseudoobscura ]

Gene ID: 4813950, updated on 23-May-2024

Summary

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Gene symbol
Cbl
Gene description
E3 ubiquitin-protein ligase CBL
See related
EnsemblRapid:LOC4813950
Gene type
protein coding
RefSeq status
MODEL
Organism
Drosophila pseudoobscura
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Orthologs
fruit fly all
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Genomic context

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See Cbl in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Annotation release Status Assembly Chr Location
104 current UCI_Dpse_MV25 (GCF_009870125.1) X NC_046683.1 (55655462..55662053)

Chromosome X - NC_046683.1Genomic Context describing neighboring genes Neighboring gene protein matrimony Neighboring gene exocyst complex component 7 Neighboring gene agrin Neighboring gene cold shock domain-containing Unr Neighboring gene AFG3-like protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_046683.1 Chromosome X Reference UCI_Dpse_MV25 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evaluation of different reference based annotation strategies using RNA-Seq - a case study in Drososphila pseudoobscura. Palmieri N, et al. PLoS One, 2012. PMID 23056304, Free PMC Article
  2. Evolution of genes and genomes on the Drosophila phylogeny. Drosophila 12 Genomes Consortium, et al. Nature, 2007 Nov 8. PMID 17994087

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL-B-B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Drosophila pseudoobscura Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCI_Dpse_MV25 Primary Assembly

Genomic

  1. NC_046683.1 Reference UCI_Dpse_MV25 Primary Assembly

    Range
    55655462..55662053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001354074.4 → XP_001354110.3  E3 ubiquitin-protein ligase CBL-B-B

    UniProtKB/TrEMBL
    A0A6I8UEC1
    Related
    XP_001354110.3, XM_001354074.4
    Conserved Domains (6) summary
    cd09920
    Location:243 → 337
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    PRK07003
    Location:546 → 689
    PRK07003; DNA polymerase III subunit gamma/tau
    cd14318
    Location:842 → 881
    UBA_Cbl_like; UBA domain found in casitas B-lineage lymphoma (Cbl) proteins
    cd16709
    Location:350 → 415
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:41 → 159
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:166 → 249
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
Nucleotide Protein Strain
Heading Accession and Version

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