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PRMT5 protein arginine methyltransferase 5 [ Canis lupus familiaris (dog) ]

Gene ID: 480242, updated on 17-Aug-2024

Summary

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Official Symbol
PRMT5provided by VGNC
Official Full Name
protein arginine methyltransferase 5provided by VGNC
Primary source
VGNC:VGNC:44998
See related
Ensembl:ENSCAFG00845002461
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See PRMT5 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (3356162..3365422, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (3196693..3205933, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (3371200..3380454, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (3047415..3056657, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (3108945..3118202, complement)

Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene RRAD and GEM like GTPase 2 Neighboring gene uncharacterized LOC111096963 Neighboring gene RNA binding motif protein 23 Neighboring gene transfer RNA arginine (anticodon ACG) Neighboring gene ajuba LIM protein Neighboring gene uncharacterized LOC111096962

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone arginine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-arginine N-methylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein arginine N-methyltransferase 5
XP_022277509.1
XP_022277510.1
XP_038338682.1
XP_038338683.1
XP_038338684.1
XP_038338685.1
XP_038338686.1
XP_038400103.1
XP_038400104.1
XP_038400105.1
XP_038400106.1
XP_038400107.1
XP_038439266.1
XP_038464224.1
XP_038464225.1
XP_038464226.1
XP_038464227.1
XP_038464228.1
XP_038529028.1
XP_038529029.1
XP_038529030.1
XP_038529031.1
XP_038529032.1
XP_537366.2
XP_857529.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051812.1 Reference ROS_Cfam_1.0

    Range
    3356162..3365422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038673101.1 → XP_038529029.1  protein arginine N-methyltransferase 5 isoform X2

    UniProtKB/TrEMBL
    A0A8C0NN99, A0A8C0PPS3, A0A8C0QWZ0, A0A8I3RQT2
    Related
    ENSCAFP00845003643.1, ENSCAFT00845004559.1
    Conserved Domains (3) summary
    pfam05185
    Location:295 → 464
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:37 → 290
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:468 → 635
    PRMT5_C; PRMT5 oligomerization domain

  2. XM_038673100.1 → XP_038529028.1  protein arginine N-methyltransferase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NN99
    Conserved Domains (3) summary
    pfam05185
    Location:305 → 474
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:37 → 300
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:478 → 645
    PRMT5_C; PRMT5 oligomerization domain

  3. XM_038673104.1 → XP_038529032.1  protein arginine N-methyltransferase 5 isoform X5

    UniProtKB/TrEMBL
    A0A8C0NQU7
    Conserved Domains (3) summary
    pfam05185
    Location:189 → 358
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:1 → 184
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:362 → 529
    PRMT5_C; PRMT5 oligomerization domain

  4. XM_038673102.1 → XP_038529030.1  protein arginine N-methyltransferase 5 isoform X3

    UniProtKB/TrEMBL
    A0A8C0NQU7
    Conserved Domains (3) summary
    pfam05185
    Location:288 → 457
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:20 → 283
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:461 → 628
    PRMT5_C; PRMT5 oligomerization domain

  5. XM_038673103.1 → XP_038529031.1  protein arginine N-methyltransferase 5 isoform X4

    UniProtKB/TrEMBL
    A0A8C0NQU7, A0A8C0RV99, A0A8I3MM19
    Related
    ENSCAFP00845003687.1, ENSCAFT00845004614.1
    Conserved Domains (3) summary
    pfam05185
    Location:278 → 447
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:20 → 273
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:451 → 618
    PRMT5_C; PRMT5 oligomerization domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049268.1 Alternate UMICH_Zoey_3.1

    Range
    3047415..3056657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038482755.1 → XP_038338683.1  protein arginine N-methyltransferase 5 isoform X2

    Conserved Domains (3) summary
    pfam05185
    Location:295 → 464
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:37 → 290
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:468 → 635
    PRMT5_C; PRMT5 oligomerization domain

  2. XM_038482754.1 → XP_038338682.1  protein arginine N-methyltransferase 5 isoform X1

    Conserved Domains (3) summary
    pfam05185
    Location:305 → 474
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:37 → 300
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:478 → 645
    PRMT5_C; PRMT5 oligomerization domain

  3. XM_038482758.1 → XP_038338686.1  protein arginine N-methyltransferase 5 isoform X5

    Conserved Domains (3) summary
    pfam05185
    Location:189 → 358
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:1 → 184
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:362 → 529
    PRMT5_C; PRMT5 oligomerization domain

  4. XM_038482756.1 → XP_038338684.1  protein arginine N-methyltransferase 5 isoform X3

    Conserved Domains (3) summary
    pfam05185
    Location:288 → 457
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:20 → 283
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:461 → 628
    PRMT5_C; PRMT5 oligomerization domain

  5. XM_038482757.1 → XP_038338685.1  protein arginine N-methyltransferase 5 isoform X4

    Conserved Domains (3) summary
    pfam05185
    Location:278 → 447
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:20 → 273
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:451 → 618
    PRMT5_C; PRMT5 oligomerization domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

    Range
    3108945..3118202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038608297.1 → XP_038464225.1  protein arginine N-methyltransferase 5 isoform X2

    Conserved Domains (3) summary
    pfam05185
    Location:295 → 464
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:37 → 290
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:468 → 635
    PRMT5_C; PRMT5 oligomerization domain

  2. XM_038608296.1 → XP_038464224.1  protein arginine N-methyltransferase 5 isoform X1

    Conserved Domains (3) summary
    pfam05185
    Location:305 → 474
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:37 → 300
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:478 → 645
    PRMT5_C; PRMT5 oligomerization domain

  3. XM_038608300.1 → XP_038464228.1  protein arginine N-methyltransferase 5 isoform X5

    Conserved Domains (3) summary
    pfam05185
    Location:189 → 358
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:1 → 184
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:362 → 529
    PRMT5_C; PRMT5 oligomerization domain

  4. XM_038608298.1 → XP_038464226.1  protein arginine N-methyltransferase 5 isoform X3

    Conserved Domains (3) summary
    pfam05185
    Location:288 → 457
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:20 → 283
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:461 → 628
    PRMT5_C; PRMT5 oligomerization domain

  5. XM_038608299.1 → XP_038464227.1  protein arginine N-methyltransferase 5 isoform X4

    Conserved Domains (3) summary
    pfam05185
    Location:278 → 447
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:20 → 273
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:451 → 618
    PRMT5_C; PRMT5 oligomerization domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

    Range
    3371200..3380454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038544176.1 → XP_038400104.1  protein arginine N-methyltransferase 5 isoform X2

    UniProtKB/TrEMBL
    A0A8C0NN99, A0A8C0PPS3, A0A8C0QWZ0, A0A8I3RQT2
    Conserved Domains (3) summary
    pfam05185
    Location:295 → 464
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:37 → 290
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:468 → 635
    PRMT5_C; PRMT5 oligomerization domain

  2. XM_038544175.1 → XP_038400103.1  protein arginine N-methyltransferase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NN99
    Conserved Domains (3) summary
    pfam05185
    Location:305 → 474
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:37 → 300
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:478 → 645
    PRMT5_C; PRMT5 oligomerization domain

  3. XM_038544179.1 → XP_038400107.1  protein arginine N-methyltransferase 5 isoform X5

    UniProtKB/TrEMBL
    A0A8C0NQU7
    Conserved Domains (3) summary
    pfam05185
    Location:189 → 358
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:1 → 184
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:362 → 529
    PRMT5_C; PRMT5 oligomerization domain

  4. XM_038544177.1 → XP_038400105.1  protein arginine N-methyltransferase 5 isoform X3

    UniProtKB/TrEMBL
    A0A8C0NQU7
    Conserved Domains (3) summary
    pfam05185
    Location:288 → 457
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:20 → 283
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:461 → 628
    PRMT5_C; PRMT5 oligomerization domain

  5. XM_038544178.1 → XP_038400106.1  protein arginine N-methyltransferase 5 isoform X4

    UniProtKB/TrEMBL
    A0A8C0NQU7, A0A8C0RV99, A0A8I3MM19
    Conserved Domains (3) summary
    pfam05185
    Location:278 → 447
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:20 → 273
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:451 → 618
    PRMT5_C; PRMT5 oligomerization domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    3196693..3205933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_537366.7 → XP_537366.2  protein arginine N-methyltransferase 5 isoform X2

    UniProtKB/TrEMBL
    A0A8C0NN99, A0A8C0PPS3, A0A8C0QWZ0, A0A8I3RQT2
    Conserved Domains (3) summary
    pfam05185
    Location:295 → 464
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:37 → 290
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:468 → 635
    PRMT5_C; PRMT5 oligomerization domain

  2. XM_022421801.2 → XP_022277509.1  protein arginine N-methyltransferase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NN99
    Conserved Domains (3) summary
    pfam05185
    Location:305 → 474
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:37 → 300
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:478 → 645
    PRMT5_C; PRMT5 oligomerization domain

  3. XM_038583338.1 → XP_038439266.1  protein arginine N-methyltransferase 5 isoform X5

    UniProtKB/TrEMBL
    A0A8C0NQU7
    Conserved Domains (3) summary
    pfam05185
    Location:189 → 358
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:1 → 184
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:362 → 529
    PRMT5_C; PRMT5 oligomerization domain

  4. XM_022421802.2 → XP_022277510.1  protein arginine N-methyltransferase 5 isoform X3

    UniProtKB/TrEMBL
    A0A8C0NQU7
    Conserved Domains (3) summary
    pfam05185
    Location:288 → 457
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:20 → 283
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:461 → 628
    PRMT5_C; PRMT5 oligomerization domain

  5. XM_852436.4 → XP_857529.1  protein arginine N-methyltransferase 5 isoform X4

    UniProtKB/TrEMBL
    A0A8C0NQU7, A0A8C0RV99, A0A8I3MM19
    Conserved Domains (3) summary
    pfam05185
    Location:278 → 447
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:20 → 273
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:451 → 618
    PRMT5_C; PRMT5 oligomerization domain
Nucleotide Protein
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