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rin rasputin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47998, updated on 2-Nov-2024

Summary

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Official Symbol
rinprovided by FlyBase
Official Full Name
rasputinprovided by FlyBase
Primary source
FLYBASE:FBgn0015778
Locus tag
Dmel_CG9412
See related
AllianceGenome:FB:FBgn0015778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg9412; CG9412; Dmel\CG9412; Nts; rasp; Rin; RIN
Summary
Predicted to enable DNA helicase activity; RNA helicase activity; and mRNA binding activity. Involved in several processes, including compound eye morphogenesis; dorsal/ventral axis specification, ovarian follicular epithelium; and stress granule assembly. Located in cytoplasmic stress granule and cytosol. Part of ribonucleoprotein complex. Is expressed in several structures, including adult head; eye disc; female germline cyst; follicle cell; and ovary. Orthologous to human G3BP1 (G3BP stress granule assembly factor 1) and G3BP2 (G3BP stress granule assembly factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See rin in Genome Data Viewer
Location:
87F6-87F7; 3-54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13647004..13654527)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9472726..9480249)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene squid Neighboring gene RNA-binding protein 4 Neighboring gene Heterogeneous nuclear ribonucleoprotein at 87F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Detecting Stress Granules in Drosophila Neurons. De Graeve F, et al. Methods Mol Biol, 2022. PMID 35171483
  2. Disruption of Stress Granule Formation by the Multifunctional Cricket Paralysis Virus 1A Protein. Khong A, et al. J Virol, 2017 Mar 1. PMID 28003491, Free PMC Article
  3. Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster. Vognsen T, et al. Biochem Biophys Res Commun, 2012 Mar 30. PMID 22414690
  4. Rasputin, more promiscuous than ever: a review of G3BP. Irvine K, et al. Int J Dev Biol, 2004 Dec. PMID 15602692
  5. The transcriptional response to oxidative stress is independent of stress-granule formation. Singh A, et al. Mol Biol Cell, 2022 Mar 1. PMID 34985933, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs.
    Title: The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs.
  2. Rasputin functions as a positive regulator of orb in Drosophila oogenesis.
    Title: Rasputin functions as a positive regulator of orb in Drosophila oogenesis.
  3. Lig regulates cell proliferation during development in concert with Rin, Capr and FMR1.
    Title: The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster.
  4. The crystal structure of the NTF2-like domain of the Drosophila homolog of Ras GTPase SH3 Binding Protein (G3BP), Rasputin, was determined at 2.7A resolution.
    Title: Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster.
  5. G3BPs are scaffolding proteins linking signal transduction to RNA metabolism (review)
    Title: Rasputin, more promiscuous than ever: a review of G3BP.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in compound eye photoreceptor fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal/ventral axis specification, ovarian follicular epithelium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dorsal/ventral axis specification, ovarian follicular epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ommatidial rotation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to amino acid starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in stress granule assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stress granule assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 
part_of ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
rasputin
Names
CG9412-PB
CG9412-PE
CG9412-PF
CG9412-PG
next to squid
rin-PB
rin-PE
rin-PF
rin-PG
NP_524907.2
NP_731828.1
NP_731829.1
NP_731830.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13647004..13654527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169533.2 → NP_731830.2  rasputin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731830.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9I7J5, Q9NH72, Q9VFT4
    Related
    FBpp0312064
    Conserved Domains (3) summary
    COG0724
    Location:423 → 557
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00780
    Location:12 → 131
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12229
    Location:490 → 580
    RRM_G3BP; RNA recognition motif (RRM) in ras GTPase-activating protein-binding protein G3BP1, G3BP2 and similar proteins

  2. NM_169532.2 → NP_731829.1  rasputin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731829.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9I7J5, Q9NH72, Q9VFT4
    Related
    FBpp0082267
    Conserved Domains (3) summary
    COG0724
    Location:423 → 557
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00780
    Location:12 → 131
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12229
    Location:490 → 580
    RRM_G3BP; RNA recognition motif (RRM) in ras GTPase-activating protein-binding protein G3BP1, G3BP2 and similar proteins

  3. NM_080168.3 → NP_524907.2  rasputin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524907.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9I7J5, Q9NH72, Q9VFT4
    Related
    FBpp0082265
    Conserved Domains (3) summary
    COG0724
    Location:423 → 557
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00780
    Location:12 → 131
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12229
    Location:490 → 580
    RRM_G3BP; RNA recognition motif (RRM) in ras GTPase-activating protein-binding protein G3BP1, G3BP2 and similar proteins

  4. NM_169531.2 → NP_731828.1  rasputin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731828.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9I7J5, Q9NH72, Q9VFT4
    Related
    FBpp0312063
    Conserved Domains (3) summary
    COG0724
    Location:423 → 557
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00780
    Location:12 → 131
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12229
    Location:490 → 580
    RRM_G3BP; RNA recognition motif (RRM) in ras GTPase-activating protein-binding protein G3BP1, G3BP2 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NH72 Q9NH72
Q9VFT4 Q9VFT4

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