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WDR59 WD repeat domain 59 [ Canis lupus familiaris (dog) ]

Gene ID: 479653, updated on 17-Aug-2024

Summary

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Official Symbol
WDR59provided by VGNC
Official Full Name
WD repeat domain 59provided by VGNC
Primary source
VGNC:VGNC:48376
See related
Ensembl:ENSCAFG00845025137
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See WDR59 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
28
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (76063062..76167417)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (75682883..75787024)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (76282007..76385796)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (75967200..76070873)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (75789796..75893615)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase D Neighboring gene zinc and ring finger 1 Neighboring gene uncharacterized LOC119871949 Neighboring gene fatty acid 2-hydroxylase Neighboring gene ring finger and WD repeat domain 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
WD repeat-containing protein 59; GATOR complex protein WDR59

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    76063062..76167417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038667058.1 → XP_038522986.1  GATOR complex protein WDR59 isoform X4

    Conserved Domains (3) summary
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cl02687
    Location:394 → 463
    RWD; RWD domain
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_038667055.1 → XP_038522983.1  GATOR complex protein WDR59 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JIS8, A0A8C0JJB2, A0A8C0M5E4, A0A8I3PXQ8
    Related
    ENSCAFP00845034972.1, ENSCAFT00845044634.1
    Conserved Domains (4) summary
    smart00591
    Location:394 → 494
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:937 → 983
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_038667056.1 → XP_038522984.1  GATOR complex protein WDR59 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JIL0, A0A8C0M6W4, A0A8I3PXL5, A0A8I3Q707, A0A8P0P3R5
    Related
    ENSCAFP00845034767.1, ENSCAFT00845044367.1
    Conserved Domains (4) summary
    smart00591
    Location:394 → 494
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:918 → 964
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_038667057.1 → XP_038522985.1  GATOR complex protein WDR59 isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q707, A0A8P0P3R5
    Conserved Domains (4) summary
    smart00591
    Location:350 → 450
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:18 → 59
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:893 → 939
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:56 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    75967200..76070873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038477143.1 → XP_038333071.1  GATOR complex protein WDR59 isoform X4

    Conserved Domains (3) summary
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cl02687
    Location:394 → 463
    RWD; RWD domain
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_038477140.1 → XP_038333068.1  GATOR complex protein WDR59 isoform X1

    Conserved Domains (4) summary
    smart00591
    Location:394 → 494
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:937 → 983
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_038477141.1 → XP_038333069.1  GATOR complex protein WDR59 isoform X2

    Conserved Domains (4) summary
    smart00591
    Location:394 → 494
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:918 → 964
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_038477142.1 → XP_038333070.1  GATOR complex protein WDR59 isoform X3

    Conserved Domains (4) summary
    smart00591
    Location:350 → 450
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:18 → 59
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:893 → 939
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:56 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    75789796..75893615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038602452.1 → XP_038458380.1  GATOR complex protein WDR59 isoform X4

    Conserved Domains (3) summary
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cl02687
    Location:394 → 463
    RWD; RWD domain
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_038602449.1 → XP_038458377.1  GATOR complex protein WDR59 isoform X1

    Conserved Domains (4) summary
    smart00591
    Location:394 → 494
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:937 → 983
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_038602450.1 → XP_038458378.1  GATOR complex protein WDR59 isoform X2

    Conserved Domains (4) summary
    smart00591
    Location:394 → 494
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:918 → 964
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_038602451.1 → XP_038458379.1  GATOR complex protein WDR59 isoform X3

    Conserved Domains (4) summary
    smart00591
    Location:350 → 450
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:18 → 59
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:893 → 939
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:56 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    76282007..76385796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038538330.1 → XP_038394258.1  GATOR complex protein WDR59 isoform X4

    Conserved Domains (3) summary
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cl02687
    Location:394 → 463
    RWD; RWD domain
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_038538327.1 → XP_038394255.1  GATOR complex protein WDR59 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JIS8, A0A8C0JJB2, A0A8C0M5E4, A0A8I3PXQ8
    Conserved Domains (4) summary
    smart00591
    Location:394 → 494
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:937 → 983
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_038538328.1 → XP_038394256.1  GATOR complex protein WDR59 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JIL0, A0A8C0M6W4, A0A8I3PXL5, A0A8I3Q707, A0A8P0P3R5
    Conserved Domains (4) summary
    smart00591
    Location:394 → 494
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:918 → 964
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_038538329.1 → XP_038394257.1  GATOR complex protein WDR59 isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q707, A0A8P0P3R5
    Conserved Domains (4) summary
    smart00591
    Location:350 → 450
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:18 → 59
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:893 → 939
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:56 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    75682883..75787024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022419190.2 → XP_022274898.1  GATOR complex protein WDR59 isoform X4

    Conserved Domains (3) summary
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cl02687
    Location:394 → 463
    RWD; RWD domain
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_005620697.4 → XP_005620754.1  GATOR complex protein WDR59 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JIS8, A0A8C0JJB2, A0A8C0M5E4, A0A8I3PXQ8
    Conserved Domains (4) summary
    smart00591
    Location:394 → 494
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:937 → 983
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_536785.7 → XP_536785.3  GATOR complex protein WDR59 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JIL0, A0A8C0M6W4, A0A8I3PXL5, A0A8I3Q707, A0A8P0P3R5
    Conserved Domains (4) summary
    smart00591
    Location:394 → 494
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:918 → 964
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_038527695.1 → XP_038383623.1  GATOR complex protein WDR59 isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q707, A0A8P0P3R5
    Conserved Domains (4) summary
    smart00591
    Location:350 → 450
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:18 → 59
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:893 → 939
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:56 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
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