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HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 479005, updated on 17-Aug-2024

Summary

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Official Symbol
HERC2provided by VGNC
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 2provided by VGNC
Primary source
VGNC:VGNC:103647
See related
Ensembl:ENSCAFG00845016369
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See HERC2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
95
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (32370920..32613992)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (34716991..34960078)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (32265346..32508054)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (31904221..32147887)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (32153608..32396909)

Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene EMI domain-containing protein 1-like Neighboring gene NIPA magnesium transporter 1 Neighboring gene ribosomal protein L27a pseudogene Neighboring gene OCA2 melanosomal transmembrane protein Neighboring gene ATP synthase subunit delta, mitochondrial-like Neighboring gene uncharacterized LOC119871181

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HERC2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2
Names
hect domain and RLD 2
XP_005618257.1
XP_005618258.1
XP_013967757.1
XP_022272507.1
XP_022272508.1
XP_022272510.1
XP_038327565.1
XP_038327566.1
XP_038327567.1
XP_038327568.1
XP_038327569.1
XP_038327570.1
XP_038327571.1
XP_038328566.1
XP_038388496.1
XP_038452789.1
XP_038452790.1
XP_038452791.1
XP_038452792.1
XP_038452793.1
XP_038452794.1
XP_038452795.1
XP_038516999.1
XP_038517000.1
XP_038517001.1
XP_038517002.1
XP_038517003.1
XP_038517004.1
XP_038517005.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051807.1 Reference ROS_Cfam_1.0

    Range
    32370920..32613992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038661071.1 → XP_038516999.1  E3 ubiquitin-protein ligase HERC2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3P005
    Conserved Domains (9) summary
    cd08664
    Location:2766 → 2911
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2953 → 3323
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4424 → 4795
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2707 → 2751
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2461 → 2508
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1212 → 1283
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1871 → 1931
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2555 → 2632
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam18346
    Location:2640 → 2697
    SH3_15; Mind bomb SH3 repeat domain

  2. XM_038661074.1 → XP_038517002.1  E3 ubiquitin-protein ligase HERC2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3P005
    Conserved Domains (9) summary
    cd08664
    Location:2765 → 2910
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2952 → 3322
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4423 → 4794
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2706 → 2750
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2460 → 2507
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1212 → 1283
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1871 → 1931
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2554 → 2631
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam18346
    Location:2639 → 2696
    SH3_15; Mind bomb SH3 repeat domain

  3. XM_038661075.1 → XP_038517003.1  E3 ubiquitin-protein ligase HERC2 isoform X3

    UniProtKB/TrEMBL
    A0A8I3P005
    Conserved Domains (9) summary
    cd08664
    Location:2761 → 2906
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2948 → 3318
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4419 → 4790
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2702 → 2746
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2456 → 2503
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1207 → 1278
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1866 → 1926
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2550 → 2627
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam18346
    Location:2635 → 2692
    SH3_15; Mind bomb SH3 repeat domain

  4. XM_038661076.1 → XP_038517004.1  E3 ubiquitin-protein ligase HERC2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0MI56
    Conserved Domains (9) summary
    cd08664
    Location:2720 → 2865
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2907 → 3277
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4378 → 4749
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2661 → 2705
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2415 → 2462
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1166 → 1237
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1825 → 1885
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2509 → 2586
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam18346
    Location:2594 → 2651
    SH3_15; Mind bomb SH3 repeat domain

  5. XM_038661072.1 → XP_038517000.1  E3 ubiquitin-protein ligase HERC2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3P005
    Conserved Domains (9) summary
    cd08664
    Location:2766 → 2911
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2953 → 3323
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4424 → 4795
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2707 → 2751
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2461 → 2508
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1212 → 1283
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1871 → 1931
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2555 → 2632
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam18346
    Location:2640 → 2697
    SH3_15; Mind bomb SH3 repeat domain

  6. XM_038661073.1 → XP_038517001.1  E3 ubiquitin-protein ligase HERC2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3P005
    Related
    ENSCAFP00845022913.1, ENSCAFT00845029133.1
    Conserved Domains (9) summary
    cd08664
    Location:2766 → 2911
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2953 → 3323
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4424 → 4795
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2707 → 2751
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2461 → 2508
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1212 → 1283
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1871 → 1931
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2555 → 2632
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam18346
    Location:2640 → 2697
    SH3_15; Mind bomb SH3 repeat domain

  7. XM_038661077.1 → XP_038517005.1  E3 ubiquitin-protein ligase HERC2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0RXT0
    Conserved Domains (9) summary
    cd08664
    Location:1963 → 2108
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2150 → 2520
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:3621 → 3992
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:1904 → 1948
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:1658 → 1705
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:409 → 480
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1068 → 1128
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:1752 → 1829
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam18346
    Location:1837 → 1894
    SH3_15; Mind bomb SH3 repeat domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049263.1 Alternate UMICH_Zoey_3.1

    Range
    31904221..32147887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038471637.1 → XP_038327565.1  E3 ubiquitin-protein ligase HERC2 isoform X1

  2. XM_038471640.1 → XP_038327568.1  E3 ubiquitin-protein ligase HERC2 isoform X2

  3. XM_038471641.1 → XP_038327569.1  E3 ubiquitin-protein ligase HERC2 isoform X3

  4. XM_038471642.1 → XP_038327570.1  E3 ubiquitin-protein ligase HERC2 isoform X4

    Conserved Domains (9) summary
    cd08664
    Location:2720 → 2865
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2907 → 3277
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4378 → 4749
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2661 → 2705
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2415 → 2462
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1166 → 1237
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1825 → 1885
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2509 → 2586
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam18346
    Location:2594 → 2651
    SH3_15; Mind bomb SH3 repeat domain

  5. XM_038471638.1 → XP_038327566.1  E3 ubiquitin-protein ligase HERC2 isoform X1

  6. XM_038471639.1 → XP_038327567.1  E3 ubiquitin-protein ligase HERC2 isoform X1

  7. XM_038471643.1 → XP_038327571.1  E3 ubiquitin-protein ligase HERC2 isoform X5

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

    Range
    32153608..32396909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038596861.1 → XP_038452789.1  E3 ubiquitin-protein ligase HERC2 isoform X1

  2. XM_038596864.1 → XP_038452792.1  E3 ubiquitin-protein ligase HERC2 isoform X2

  3. XM_038596865.1 → XP_038452793.1  E3 ubiquitin-protein ligase HERC2 isoform X3

  4. XM_038596866.1 → XP_038452794.1  E3 ubiquitin-protein ligase HERC2 isoform X4

    Conserved Domains (9) summary
    cd08664
    Location:2720 → 2865
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2907 → 3277
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4378 → 4749
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2661 → 2705
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2415 → 2462
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1166 → 1237
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1825 → 1885
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2509 → 2586
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam18346
    Location:2594 → 2651
    SH3_15; Mind bomb SH3 repeat domain

  5. XM_038596862.1 → XP_038452790.1  E3 ubiquitin-protein ligase HERC2 isoform X1

  6. XM_038596863.1 → XP_038452791.1  E3 ubiquitin-protein ligase HERC2 isoform X1

  7. XM_038596867.1 → XP_038452795.1  E3 ubiquitin-protein ligase HERC2 isoform X5

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

    Range
    32265346..32508054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038532568.1 → XP_038388496.1  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2 isoform X1

    UniProtKB/TrEMBL
    A0A8P0NV78

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    34716991..34960078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014112282.3 → XP_013967757.1  E3 ubiquitin-protein ligase HERC2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R7B5, A0A8P0NV78
    Conserved Domains (8) summary
    cd08664
    Location:2766 → 2911
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    cd00078
    Location:4424 → 4795
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2707 → 2751
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2461 → 2508
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1212 → 1283
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1871 → 1930
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2555 → 2632
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl27697
    Location:2953 → 3323
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  2. XM_005618200.4 → XP_005618257.1  E3 ubiquitin-protein ligase HERC2 isoform X2

    UniProtKB/TrEMBL
    A0A8P0NV78
    Conserved Domains (8) summary
    cd08664
    Location:2765 → 2910
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    cd00078
    Location:4423 → 4794
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2706 → 2750
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2460 → 2507
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1212 → 1283
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1871 → 1930
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2554 → 2631
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl27697
    Location:2952 → 3322
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  3. XM_005618201.4 → XP_005618258.1  E3 ubiquitin-protein ligase HERC2 isoform X3

    UniProtKB/TrEMBL
    A0A8P0NV78
    Conserved Domains (8) summary
    cd08664
    Location:2761 → 2906
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    cd00078
    Location:4419 → 4790
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2702 → 2746
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2456 → 2503
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1207 → 1278
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1866 → 1925
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2550 → 2627
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl27697
    Location:2948 → 3318
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  4. XM_038472638.1 → XP_038328566.1  E3 ubiquitin-protein ligase HERC2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0MI56, A0A8C0PZY7
    Conserved Domains (9) summary
    cd08664
    Location:2720 → 2865
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2907 → 3277
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4378 → 4749
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2661 → 2705
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2415 → 2462
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1166 → 1237
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1825 → 1885
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2509 → 2586
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam18346
    Location:2594 → 2651
    SH3_15; Mind bomb SH3 repeat domain

  5. XM_022416799.2 → XP_022272507.1  E3 ubiquitin-protein ligase HERC2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R7B5, A0A8P0NV78
    Conserved Domains (8) summary
    cd08664
    Location:2766 → 2911
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    cd00078
    Location:4424 → 4795
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2707 → 2751
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2461 → 2508
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1212 → 1283
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1871 → 1930
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2555 → 2632
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl27697
    Location:2953 → 3323
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  6. XM_022416800.2 → XP_022272508.1  E3 ubiquitin-protein ligase HERC2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R7B5, A0A8P0NV78
    Conserved Domains (8) summary
    cd08664
    Location:2766 → 2911
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    cd00078
    Location:4424 → 4795
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2707 → 2751
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2461 → 2508
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:1212 → 1283
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1871 → 1930
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:2555 → 2632
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl27697
    Location:2953 → 3323
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  7. XM_022416802.2 → XP_022272510.1  E3 ubiquitin-protein ligase HERC2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0RXT0
    Conserved Domains (8) summary
    cd08664
    Location:1963 → 2108
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    cd00078
    Location:3621 → 3992
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:1904 → 1948
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:1658 → 1705
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
    pfam00173
    Location:409 → 480
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam06701
    Location:1068 → 1127
    MIB_HERC2; Mib_herc2
    pfam11515
    Location:1752 → 1829
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl27697
    Location:2150 → 2520
    RCC1; Regulator of chromosome condensation (RCC1) repeat
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