NFKB1 nuclear factor kappa B subunit 1 [ Homo sapiens (human) ]

Gene ID: 4790, updated on 11-Apr-2024

Summary

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Official Symbol: NFKB1provided by HGNC
Official Full Name: nuclear factor kappa B subunit 1provided by HGNC
Primary source: HGNC:HGNC:7794
See related: Ensembl:ENSG00000109320 MIM:164011; AllianceGenome:HGNC:7794
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta
Summary: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Ubiquitous expression in bone marrow (RPKM 27.7), appendix (RPKM 20.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

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See NFKB1 in Genome Data Viewer

Location:: 4q24

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (102501359..102617302)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (105815285..105931246)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (103422516..103538459)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ_0026218 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell dysfunction by regulating miR-188-3p/TLR4/NF-kappaB pathway.
Title: Circ_0026218 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell dysfunction by regulating miR-188-3p/TLR4/NF-κB pathway.
RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-kappaB pathway.
Title: RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway.
WNT2B activates macrophages via NF-kappaB signaling pathway in inflammatory bowel disease.
Title: WNT2B activates macrophages via NF-κB signaling pathway in inflammatory bowel disease.
Breast cancer malignancy is governed by regulation of the macroH2A2/TM4SF1 axis, the AKT/NF-kappaB pathway, and elevated MMP13 expression.
Title: Breast cancer malignancy is governed by regulation of the macroH2A2/TM4SF1 axis, the AKT/NF-κB pathway, and elevated MMP13 expression.
NFkappaB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins.
Title: NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins.
Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-kappaB/NLRP3 pathway.
Title: Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway.
Gene-to-gene coordinated regulation of transcription and alternative splicing by 3D chromatin remodeling upon NF-kappaB activation.
Title: Gene-to-gene coordinated regulation of transcription and alternative splicing by 3D chromatin remodeling upon NF-κB activation.
TIMP1/CHI3L1 facilitates glioma progression and immunosuppression via NF-kappaB activation.
Title: TIMP1/CHI3L1 facilitates glioma progression and immunosuppression via NF-κB activation.
Up-regulation of TNF-alpha/NFkB/SIRT1 axis drives aggressiveness and cancer stem cells accumulation in chemoresistant oral squamous cell carcinoma.
Title: Up-regulation of TNF-alpha/NFkB/SIRT1 axis drives aggressiveness and cancer stem cells accumulation in chemoresistant oral squamous cell carcinoma.
A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy.
Title: A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy.

Submit: New GeneRIF Correction See all GeneRIFs (2815)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Immunodeficiency, common variable, 12 MedGen: C4225277 OMIM: 616576 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of treatment refractory schizophrenia in Han Chinese. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Monocyte derived dendritic cells from HIV-infected clinical samples downregulate NFKB1 (NK-kB) expression	PubMed
Knockdown of nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1; p50/p105) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed
Knockdown of nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1; p50/p105) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Asp	asp	Analysis of point mutations in the USF1 and NF-kappaB sites in the cis-acting elements of ASP promoter region shows that USF1 and NF-kappaB are required for ASP activity	PubMed
Envelope surface glycoprotein gp120	env	The binding of soluble HIV-1 gp120 to TLR2 or TLR4 results in upregulation of the TNF-alpha and IL-8 production through NF-kappaB activation	PubMed
	env	HIV-1 gp120 and methamphetamine synergistically induce release of IL-6 through the NF-kappaB pathway in astrocytes	PubMed
	env	HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-KapaB pathway	PubMed
	env	HIV-1 gp120 induces a time-dependent IL-6 upregulation by translocating NF-kappaB1 from cytoplasm to nucleus in human astrocyte cells	PubMed
	env	HIV-1 gp120-mediated downregulation of P-gp is attenuated by SN50 (a nuclear factor-KappaB [NF-KappaB] inhibitor), suggesting involvement of NF-KappaB signaling in P-gp regulation in primary cultures of human fetal astrocytes	PubMed
	env	HIV-1 gp120 activates NF-kappaB by inducing phosphorylation of IkappaBalpha in human astrocyte cells	PubMed
	env	HIV-1 gp120-mediated upregulation of CCL5 expression requires the NF-kappaB pathway in astrocytes	PubMed
	env	Inhibition of NRF2 by siRNA results in increased NOX2, NFkappaB (p65/p50), TNF-alpha, and MMP-9 proteins in astrocytes exposed to HIV-1 gp120	PubMed
	env	Increased neurotoxicity mediated by cocaine and gp120 involves signaling pathways including c-jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK), and nuclear factor (NF)-kappaB	PubMed
	env	PC-PLC is an upstream regulator of HIV-1 gp120-mediated NF-kappaB activation in human monocyte-derived macrophages	PubMed
	env	NF-kappaB and JNK signaling are involved in gp120-induced multidrug resistance protein 1 (Mrp1) regulation during an HIV-1 associated inflammatory response	PubMed
	env	Treatment of human hepatic stellate cells with gp120 significantly increases secretion and gene expression of CCL2, metalloprotease-1 and interleukin-6. Gp120 also induces activation of Akt, NF-kappaB, and p38(MAPK)	PubMed
	env	HIV-1 gp120 induces NF-kappaB activation and increases p21(cip1/waf1) and p27(kip1) protein levels in human mesangial cells	PubMed
	env	The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120	PubMed
	env	HIV-1 gp120/CD4 interaction-induced NF-kappaB activation stimulates the hyperphosphorylation of IkappaB-alpha by IkappaB kinases (IKKs)	PubMed
	env	HIV-1 envelope protein gp120 is able to induce COX-2 mRNA and protein in human neuroblastoma cell lines that express CXCR4 and CCR5 but not CD4; gp120 induces COX-2 promoter transcription through NF-kappaB and activating protein-1 (AP-1) sites	PubMed
	env	CD4-p56Lck interaction is required for HIV-1 gp120-induced nuclear translocation of NF-kappaB in HeLa cells	PubMed
	env	The protein tyrosine kinase p56lck plays an active role in transmitting an HIV-1 gp120-mediated signal that increases the oxidative state of cells and as a consequence amplifies TNF-mediated NF-kappa B DNA binding	PubMed
	env	In CD4-positive Jurkat cells, gp120 enhances TNF-induced NF-kappa B activation	PubMed
	env	Binding of heat-inactivated HIV-1 (iHIV-1) or HIV-1 gp120 to infected resting PBMCs is sufficient to activate NF-kappa B and AP-1, to induce cell surface expression of CD25, and to commit cells to produce virus	PubMed
	env	HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 Env gp41 activates NK-kB (NFKB1) in human brain microvascular endothelial cells	PubMed
	env	The HIV-1 gp41 cytoplasmic domain-induced NFkappaB activation requires TAK1, RelA, and NEMO proteins	PubMed
	env	The cytoplasmic domain (residues 704-773) of HIV-1 gp41 induces NFkappaB activation. Deletion of a 12 amino-acid sequence (762CLFSYHRLRDLL) in gp41 leads to a dramatic loss of the NFkappaB activation and tyrosine 766 is particularly important	PubMed
Nef	nef	HIV-1 Nef modulates NFKB1 activation	PubMed
	nef	The (PxxP) regions that interact with SH3 domain-containing cellular kinases as well as two acidic C-terminal residues (E154/E155) are critical for Nef-mediated enhancement of NF-kappaB activity	PubMed
	nef	HIV-1 and SIVcpz Nef proteins enhance TNF-alpha, IKK-beta, and RelA/p65-induced NF-kappaB activation in 293T cells	PubMed
	nef	HIV-1 Nef activates nuclear transcription factor NF-kappaB in human monocyte/macrophages, promonoctyes, and dendritic cells, and to a lesser extent in immature dendritic cells	PubMed
	nef	Knockdown of the p50 and p65 subunits of NF-kappaB by siRNA shows significant reduction of CCL5 levels, suggesting that NF-kappaB is involved in Nef-mediated upregulation of CCL5	PubMed
	nef	Stimulation of T cells by mitogens or antibodies to the T-cell receptor (TCR)-CD3 complex results in the downregulation of transcriptional factors NF-kappa B and AP-1 in cells expressing HIV-1 Nef	PubMed
	nef	The interaction of HIV-1 Nef with TRAF2, TRAF5, and TRAF6 proteins activates NF-kappaB, leading to the degradation of IkappaB-alpha and the increased phosphorylation of IKK-alpha and IKK-beta in monocyte-derived macrophages	PubMed
	nef	HIV-1 Nef upregulates TLR2 expression via NF-kappaB activation in THP-1 cells	PubMed
	nef	Both the myristoylation site and the acidic cluster in HIV-1 Nef are required for the activation of NF-kappaB, which induces upregulation of TNFalpha and IL6 expression	PubMed
	nef	HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that NFKB-p105 is a Nef-binding protein in Jurkat cells	PubMed
	nef	Nef-mediated activation of NF-kappaB in macrophages induces secretion of the acute-phase protein ferritin, which is necessary and sufficient for Nef-dependent B cell changes	PubMed
	nef	HIV-1 Nef suppresses immunoglobulin class-switch DNA recombination by inducing IkappaBalpha and SOCS proteins, which block CD154, IL-4 and IL-10 cytokine signaling via NF-kappaB and STAT transcription factors	PubMed
	nef	HIV-1 Nef inhibits the induction of HIV-1- and interleukin 2-directed gene expression, and the effect on HIV-1 transcription depends on an intact NF-kappa B-binding site	PubMed
	nef	HIV-1 Nef expression in Drosophila inhibits NF-kappa-B activation	PubMed
	nef	HIV-1 Nef inhibits the induction of NF-kappa B DNA-binding activity by T-cell mitogens, however Nef does not affect the DNA-binding activity of other transcription factors implicated in HIV-1 regulation, including SP-1, USF, URS, and NF-AT	PubMed
Tat	tat	HIV-1 Tat decreases NFKB1 (NF-kB) activation in Leishmania-infected macrophages	PubMed
	tat	HIV-1 Tat activates NFkappaB, causing the induction of CD95 ligand, CD69, iNOS, MCP-1, IL-2, IL-6, IL-8, IL-10, TNF-alpha, VCAM-1, ICAM-1, E-selectin, and MMP-9, as well as monocyte adhesion, cellular activation and angiogenesis	PubMed
	tat	Human microglia cells treated with HIV-1 clade C Tat show more significant upregulation of IL-6 and TNF-alpha, and higher NF-kappaB activation as compared to clade B Tat-treated cells	PubMed
	tat	HIV-1 Tat upregulates the expression of platelet-derived growth factor subunit B homodimer through activation of the PDGFR-B/MEK/NF-kappaB pathway in human brain microvascular pericytes	PubMed
	tat	HIV-1 Tat-mediated transcriptional activation of the HIV-1 LTR promoter requires NFkappaB binding sites in the promoter and involves the activation of NFkappaB by Tat	PubMed
	tat	HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins	PubMed
	tat	HIV-1 Tat enhances the NFkappaB activity by inhibiting IkappaB-alpha binding to p65 RelA	PubMed
	tat	Exogenous Nef and TNF-alpha synergistically activate NF-kappaB and AP-1 resulting in enhancing HIV-1 Tat transactivation of the LTR and viral replication in both chronically infected promonocytic cells and acutely infected primary macrophages	PubMed
	tat	HIV-1 Tat recruits P/CAF to the integrated HIV-1 LTR promoter causing the acetylation of histones, which in turn leads to the recruitment the p65 subunit of NFkappaB to the promoter	PubMed
	tat	HIV-1 Tat induces the acetylation of the NFkappaB p50 subunit as well as the p50/p65 complex by p300, causing an increase in NFkappaB DNA binding activity and in the rate of transcription	PubMed
	tat	Extracellular HIV-1 Tat upregulates the expression of human beta-defensin 2 (hBD-2) via JNK/NF-KappaB/AP-1-dependent pathways in human B cells	PubMed
	tat	The transcription factors NF-KappaB and NF-AT contribute to the Tat-induced activation of the HERV-K (HML-2) gag RNA transcripts in Jurkat T cells and in primary lymphocytes	PubMed
	tat	HIV-1 Tat enhances the NFkappaB activity and promotes the transcriptional activation of MIP-1alpha by interacting with IkappaB-alpha and p65 RelA	PubMed
	tat	MiR-217 regulates HIV-1 Tat-induced activation of NF-kappaB and inactivation of AMPK in MAGI cells	PubMed
	tat	Inhibition of human telomerase reverse transcriptase (hTERT) results in the upregulation of HIV-1 Tat-induced overexpression of intercellular adhesion molecule-1 (ICAM1) via the nuclear factor-kappaB-regulated mechanism	PubMed
	tat	Acetylation-deficient cyclin T1 mutant dominantly suppresses NF-kappaB-mediated activation of the interleukin-8 promoter but continues to synergize with the HIV Tat protein to transactivate the HIV long terminal repeat	PubMed
	tat	Herpes virus saimiri-StpC synergizes with Tat during transcriptional activation of the HIV-1 LTR. This transcriptional synergy between StpC and Tat requires Lck and NF-kappaB consensus binding sequences	PubMed
	tat	Specific C/EBP and NF-kappaB transcription factor binding elements within the IL-1beta promoter are involved in Tat regulation of IL-1beta production	PubMed
	tat	Treatment of astrocytes with cell-permeable superoxide dismutase (SOD) leads to a decrease in Tat-induced ROS generation and NF-kappaB activation	PubMed
	tat	Glutamic acids at positions 92, 94, and 96 or lysine's at positions 88, 89, and 90 in the second encoding Tat exon are critical for the activation of NF-kappaB	PubMed
	tat	HIV-1 Tat binds the deacetylase domain (amino acids 341-512) of SIRT1 and inhibits SIRT1 deacetylase activity, which results in the induction of NF-kappaB hyperacetylation	PubMed
	tat	HIV-1 Tat-mediated upregulation of MMP-9 in human astrocytes results from NF-kappaB activation pathway	PubMed
	tat	PPARalpha and PPARgamma over-expression prevent Tat-induced binding activity and transactivation of nuclear factor-kappaB	PubMed
	tat	NFKB1 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells	PubMed
	tat	HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha	PubMed
	tat	NFAT-1 negatively regulates HIV-1 Tat-mediated transactivation of the HIV-1 LTR by competing with NFkappaB for its binding to the LTR, thereby blocking the interaction of NFkappaB with Tat	PubMed
	tat	HIV-1 Tat activates NFkappaB through the cellular interferon-inducible, double-stranded RNA dependent protein kinase, PKR	PubMed
	tat	Activation of NFkappaB by HIV-1 Tat leads to a reduction in adenylyl cyclase activity and an inhibition of cAMP synthesis	PubMed
	tat	Activation of NFkappaB by HIV-1 Tat is inhibited by Nitric Oxide	PubMed
	tat	HIV-1 Tat-induced SOCS3 expression inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages in a NF-kappaB-dependent manner	PubMed
	tat	Recombinant CD40L synergizes with HIV-1 Tat to increase TNF-alpha release from primary human monocytes and microglia in an NF-kappaB-dependent manner. This synergism is attributed to a Tat-mediated up-regulation of CD40	PubMed
	tat	In HIV-1 Tat-expressing and HIV-infected astrocytes, endothelin-1 (ET-1) is significantly elevated through NF-kappaB (NF-kappaB)-responsive sites in the ET-1 promoter	PubMed
	tat	NFkappaB tethers the p160 nuclear receptor co-activator GRIP1 to the HIV-1 LTR promoter, thereby regulating the full activation of this promoter by HIV-1 Tat	PubMed
	tat	HIV-1 Tat has been shown to bind NFkappaB in vitro in gel shift, GST-pull down and affinity matrix assays	PubMed
	tat	p56-lck plays a critical role in the activation of NFkappaB by HIV-1 Tat	PubMed
	tat	HIV-1 Tat enhances tumor necrosis factor-induced activation of NFkappaB by downregulating manganese-dependent superoxide dismutase (MnSOD)	PubMed
Vpr	vpr	HIV-1 Vpr activates NFKB1 dependent upon amino acids A30, A59, H71, R73, S79, and R80 in Vpr in HeLa cells transfected with an NF-kB luciferase reporter plasmid	PubMed
	vpr	HIV-1 Vpr activates NFKB1 in HeLa cells transfected with an NF-kB luciferase reporter plasmid, which leads to G2 cell cycle arrest	PubMed
	vpr	Upregulation of IL-6, IL-10, TNFalpha, and gamma interferon is linked to HIV-1 Vpr activation of NF-kappa B	PubMed
	vpr	TNF secreted by HIV-1-infected cells (which may be attributed to Vpr) enhances NFKB1 (NK-kappa-B) activity in bystander cells AND induces replication of HIV-1 (reactivation) in a model of latently infected cells (J-Lat 10.6 cells)	PubMed
	vpr	HIV-1 Vpr induced upregulation CXCL8 (IL8) involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes	PubMed
	vpr	HIV-1 Vpr induced upregulation of IL6 involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes	PubMed
	vpr	HIV-1 Vpr-mediated upregulation of CXCL8 (IL8) involves NFKB1 (NF-kappa-B)	PubMed
	vpr	HIV-1 Vpr-mediated upregulation of IL6 involves NFKB1 (NF-kappa-B)	PubMed
	vpr	HIV-1 and SIVcpz Vpr proteins inhibit NF-kappaB, but the opposite is observed for SIVgsn/mus/mon Vpr proteins	PubMed
	vpr	HIV-1 Vpr regulates NF-kappa B, activating it in certain circumstances while suppressing it in others	PubMed
	vpr	The ability of HIV-1 Vpr to activate NF-kappaB or activator protein 1-dependent luciferase expression requires TAK1, TRAF6, or TAB3 in cells	PubMed
	vpr	HIV-1 Vpr-induced upregulation of CCL5 requires p50 and p65 subunits of NF-kappaB, p38delta MAPK, Akt-2 and Akt-3, and AP-1 transcription factor in HIV-1 Vpr transfected astrocytes	PubMed
	vpr	HIV-1 Vpr interacts with RelB to promote the Vpr-mediated activation of NF-kappaB reporter gene and to enhance the transactivation of HIV LTR	PubMed
	vpr	HIV-1 Vpr inhibits the NFkappaB signaling pathway in TNF-alpha treated cells and abolishes the phosphorylation of NFkappaB p65 subunit in response to such treatment	PubMed
	vpr	HIV-1 Vpr-induced IL-6 production depends on the activation of NFkappaB and the involvement of C/EBP-beta, TLR4, and MyD88	PubMed
	vpr	Recruitment of PARP-1 by HIV-1 Vpr-glucocorticoid receptor (GR) complex prevents its nuclear localization, which is necessary for Vpr to suppress NF-kappaB	PubMed
	vpr	HIV-1 Vpr activation of NF-kappa B regulated promoters is linked to Vpr regulation of IL-12, CD44, Toll-like receptor 4, indolamine 2,3-dioxygenase, macrophage receptor with collagenous structure, and thrombospondin 1	PubMed
	vpr	HIV-1 Vpr potentiates the trans-activation, but not the trans-repression, properties of the glucocorticoid receptor on NF-kappa B-regulated simple promoters	PubMed
	vpr	HIV-1 Vpr increases IL-8 expression and IL-8 promoter activity by activating transcription factors NF-kappa B and NF-IL-6 and also increases transcription of NF-kappa B and NF-IL-6 enhancer containing viral promoters	PubMed
	vpr	NF-kappa B contributes to HIV-1 transactivation by HIV-1 Vpr but is not completely responsible for this effect	PubMed
	vpr	Data suggests that p300, through its interactions with NF-kappa B, basal transcriptional components, and Cdks, is modulated by HIV-1 Vpr and regulates HIV replication	PubMed
	vpr	Vpr suppresses expression of IL-2, IL-10, IL-12, TNFalpha and IL-4, all of which are NF-kappa B-dependent	PubMed
	vpr	Regulation of apoptosis by HIV-1 Vpr is linked to Vpr suppression of NF-kappa B activity via the induction of I kappa B and is mapped to the first alpha-helical domain (amino acids 17-34) of Vpr	PubMed
Vpu	vpu	HIV-1 Vpu modulates NFKB1 activation	PubMed
	vpu	HIV-1 Vpu inhibits NF-kappa B activation by interfering with beta-TrCP-mediated degradation of IkappaB-alpha	PubMed
	vpu	Most HIV-1 and primate lentiviral Vpu proteins inhibit IKK-beta-induced NF-kappaB activation except HIV-1 group N Vpu proteins	PubMed
	vpu	HIV-1 Vpu inhibits endogenous expression BST2-induced NF-kappaB activity in cells, and the inhibition requires the beta-TrCP binding motif (residues 51-56; DSGxxS) in Vpu	PubMed
	vpu	NF-kappaB-mediated enhancement of the IFN-beta promoter activity is inhibited by HIV-1 Vpu	PubMed
	vpu	HIV-1 Vpu interferes with beta-TrCP to inhibit TNF-alpha-induced activation of NFkappaB	PubMed
capsid	gag	HIV-1 CA mutants N74D and P90A fail to bind to CPSF6 and cyclophilins (Nup358 and CypA), respectively, and trigger innate sensors, leading to nuclear translocation of NFkappaB and IRF3, production of type 1 IFN and induction of an antiviral state	PubMed
nucleocapsid	gag	NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells	PubMed
	gag	HIV-1 Nucleocapsid has been shown to bind to the HIV-1 LTR promoter and enhance NF-kappaB, Sp1, and TFIIB-induced HIV-1 LTR-directed RNA transcription	PubMed
retropepsin	gag-pol	HIV-1 protease can cleave p105 into a p45 maturation product and increases levels of active nuclear NF-kappa B complex	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A006S27 (e-PCR)
- UniSTS:23048

SHGC-24813 (e-PCR)
- UniSTS:40713

SHGC-12798 (e-PCR)
- UniSTS:32542

NFKB1_1991 (e-PCR)
- UniSTS:280865

SHGC-50573 (e-PCR)
- UniSTS:21549

RH46916 (e-PCR)
- UniSTS:57930

SHGC-59779 (e-PCR)
- UniSTS:75860

SHGC-24828 (e-PCR)
- UniSTS:64092

NFKB1 (e-PCR)
- UniSTS:479868

SHGC-59270 (e-PCR)
- UniSTS:81855

SHGC-50563 (e-PCR)
- UniSTS:43201

RH16194 (e-PCR)
- UniSTS:17386

SHGC-84209 (e-PCR)
- UniSTS:104698

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables actinin binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in antibacterial innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to angiotensin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to dsRNA	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-17	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-6	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nicotine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mammary gland involution	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of calcidiol 1-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cholesterol transport	IC Inferred by Curator more info	PubMed
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein metabolic process	IC Inferred by Curator more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vitamin D biosynthetic process	IC Inferred by Curator more info	PubMed
involved_in non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hyaluronan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipid storage	IC Inferred by Curator more info	PubMed
involved_in positive regulation of macrophage derived foam cell differentiation	IC Inferred by Curator more info	PubMed
involved_in positive regulation of miRNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to muscle stretch	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of I-kappaB/NF-kappaB complex	TAS Traceable Author Statement more info	PubMed
part_of NF-kappaB p50/p65 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NF-kappaB p50/p65 complex	IEA Inferred from Electronic Annotation more info
part_of chromatin	IC Inferred by Curator more info	PubMed
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	ISA Inferred from Sequence Alignment more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IGI Inferred from Genetic Interaction more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in mitochondrion	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IGI Inferred from Genetic Interaction more info	PubMed
located_in secretory granule lumen	TAS Traceable Author Statement more info
located_in specific granule lumen	TAS Traceable Author Statement more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear factor NF-kappa-B p105 subunit

Names: DNA-binding factor KBF1; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050628.1 RefSeqGene

Range

5031..120974

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1316

mRNA and Protein(s)

NM_001165412.2 → NP_001158884.1 nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein

See identical proteins and their annotated locations for NP_001158884.1

Status: REVIEWED

Source sequence(s)

AF213884, AI076882, BC051765, M58603

Consensus CDS

CCDS54783.1

UniProtKB/Swiss-Prot

A8K5Y5, B3KVE8, P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0

Related

ENSP00000378297.4, ENST00000394820.8

Conserved Domains (7) summary

cd07935
Location:42 → 243

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

COG0666
Location:499 → 705

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd01177
Location:250 → 351

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:815 → 890

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

sd00045
Location:542 → 579

ANK; ANK repeat [structural motif]

pfam12796
Location:586 → 680

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:689 → 732

Ank_2; Ankyrin repeats (3 copies)
NM_001319226.2 → NP_001306155.1 nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein

Status: REVIEWED

Source sequence(s)

AF213884, AI076882, BC051765, DB151710, M58603

Consensus CDS

CCDS54783.1

UniProtKB/Swiss-Prot

A8K5Y5, B3KVE8, P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0

Related

ENSP00000424790.1, ENST00000505458.5

Conserved Domains (7) summary

cd07935
Location:42 → 243

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

COG0666
Location:499 → 705

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd01177
Location:250 → 351

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:815 → 890

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

sd00045
Location:542 → 579

ANK; ANK repeat [structural motif]

pfam12796
Location:586 → 680

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:689 → 732

Ank_2; Ankyrin repeats (3 copies)
NM_001382625.1 → NP_001369554.1 nuclear factor NF-kappa-B p105 subunit isoform 1

Status: REVIEWED

Source sequence(s)

AF213884

Consensus CDS

CCDS3657.1

Conserved Domains (7) summary

cd07935
Location:43 → 244

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

COG0666
Location:500 → 706

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd01177
Location:251 → 352

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:816 → 891

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

sd00045
Location:543 → 580

ANK; ANK repeat [structural motif]

pfam12796
Location:587 → 681

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:690 → 733

Ank_2; Ankyrin repeats (3 copies)
NM_001382626.1 → NP_001369555.1 nuclear factor NF-kappa-B p105 subunit isoform 1

Status: REVIEWED

Source sequence(s)

AF213884

Consensus CDS

CCDS3657.1

Related

ENSP00000426147.2, ENST00000507079.6

Conserved Domains (7) summary

cd07935
Location:43 → 244

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

COG0666
Location:500 → 706

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd01177
Location:251 → 352

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:816 → 891

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

sd00045
Location:543 → 580

ANK; ANK repeat [structural motif]

pfam12796
Location:587 → 681

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:690 → 733

Ank_2; Ankyrin repeats (3 copies)
NM_001382627.1 → NP_001369556.1 nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein

Status: REVIEWED

Source sequence(s)

AF213884

Consensus CDS

CCDS54783.1

UniProtKB/Swiss-Prot

A8K5Y5, B3KVE8, P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0

Conserved Domains (7) summary

cd07935
Location:42 → 243

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

COG0666
Location:499 → 705

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd01177
Location:250 → 351

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:815 → 890

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

sd00045
Location:542 → 579

ANK; ANK repeat [structural motif]

pfam12796
Location:586 → 680

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:689 → 732

Ank_2; Ankyrin repeats (3 copies)
NM_001382628.1 → NP_001369557.1 nuclear factor NF-kappa-B p105 subunit isoform 3

Status: REVIEWED

Source sequence(s)

AF213884

Conserved Domains (7) summary

cd07935
Location:29 → 230

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

COG0666
Location:486 → 692

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd01177
Location:237 → 338

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:802 → 877

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

sd00045
Location:529 → 566

ANK; ANK repeat [structural motif]

pfam12796
Location:573 → 667

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:676 → 719

Ank_2; Ankyrin repeats (3 copies)
NM_003998.4 → NP_003989.2 nuclear factor NF-kappa-B p105 subunit isoform 1

See identical proteins and their annotated locations for NP_003989.2

Status: REVIEWED

Source sequence(s)

AF213884, AI076882, BC051765

Consensus CDS

CCDS3657.1

UniProtKB/Swiss-Prot

P19838

Related

ENSP00000226574.4, ENST00000226574.9

Conserved Domains (7) summary

cd07935
Location:43 → 244

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

COG0666
Location:500 → 706

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd01177
Location:251 → 352

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:816 → 891

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

sd00045
Location:543 → 580

ANK; ANK repeat [structural motif]

pfam12796
Location:587 → 681

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:690 → 733

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

102501359..102617302

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024454069.2 → XP_024309837.1 nuclear factor NF-kappa-B p105 subunit isoform X2

Conserved Domains (7) summary

cd00204
Location:532 → 661

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01177
Location:206 → 307

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:771 → 846

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

sd00045
Location:498 → 535

ANK; ANK repeat [structural motif]

cl08275
Location:51 → 199

RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)

pfam12796
Location:481 → 568

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:641 → 689

Ank_4; Ankyrin repeats (many copies)
XM_047415742.1 → XP_047271698.1 nuclear factor NF-kappa-B p105 subunit isoform X1
XM_024454068.1 → XP_024309836.1 nuclear factor NF-kappa-B p105 subunit isoform X1

Related

ENSP00000423877.2, ENST00000509165.2

Conserved Domains (7) summary

cd07935
Location:43 → 244

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

COG0666
Location:500 → 706

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd01177
Location:251 → 352

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:816 → 891

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

sd00045
Location:543 → 580

ANK; ANK repeat [structural motif]

pfam12796
Location:587 → 681

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:690 → 733

Ank_2; Ankyrin repeats (3 copies)
XM_047415743.1 → XP_047271699.1 nuclear factor NF-kappa-B p105 subunit isoform X3
XM_047415744.1 → XP_047271700.1 nuclear factor NF-kappa-B p105 subunit isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

105815285..105931246

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054350116.1 → XP_054206091.1 nuclear factor NF-kappa-B p105 subunit isoform X2
XM_054350115.1 → XP_054206090.1 nuclear factor NF-kappa-B p105 subunit isoform X1
XM_054350114.1 → XP_054206089.1 nuclear factor NF-kappa-B p105 subunit isoform X1
XM_054350117.1 → XP_054206092.1 nuclear factor NF-kappa-B p105 subunit isoform X3
XM_054350118.1 → XP_054206093.1 nuclear factor NF-kappa-B p105 subunit isoform X3