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PTPRN protein tyrosine phosphatase receptor type N [ Canis lupus familiaris (dog) ]

Gene ID: 478921, updated on 17-Aug-2024

Summary

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Official Symbol
PTPRNprovided by VGNC
Official Full Name
protein tyrosine phosphatase receptor type Nprovided by VGNC
Primary source
VGNC:VGNC:45193
See related
Ensembl:ENSCAFG00845030025
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
IA-2
Orthologs
human mouse all
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Genomic context

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See PTPRN in Genome Data Viewer
Location:
chromosome: 37
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 37 NC_051841.1 (25850814..25869258, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 37 NC_006619.4 (26661448..26679881, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 37 NC_049258.1 (25711218..25729647, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 37 NC_049297.1 (25755175..25773586, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 37 NC_049778.1 (25690528..25708945, complement)

Chromosome 37 - NC_051841.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102155449 Neighboring gene tubulin alpha-1B chain Neighboring gene DnaJ heat shock protein family (Hsp40) member B2 Neighboring gene uncharacterized LOC119867905 Neighboring gene aspartyl aminopeptidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autoantibodies to GAD65 and IA-2 in canine diabetes mellitus. Davison LJ, et al. Vet Immunol Immunopathol, 2008 Nov 15. PMID 18706702
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase-like N
Names
insulinoma antigen-2
receptor type N protein tyrosine phosphatase
XP_038303958.1
XP_038303959.1
XP_038319665.1
XP_038377943.1
XP_038377944.1
XP_038441750.1
XP_038441751.1
XP_038506124.1
XP_038506125.1
XP_536080.5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051841.1 Reference ROS_Cfam_1.0

    Range
    25850814..25869258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038448031.1 → XP_038303959.1  receptor-type tyrosine-protein phosphatase-like N isoform X2

    UniProtKB/TrEMBL
    A0A8C0LTE1, A0A8C0MY04
    Related
    ENSCAFP00845041846.1, ENSCAFT00845053282.1
    Conserved Domains (3) summary
    cd14609
    Location:693 → 973
    R-PTP-N; PTP-like domain of receptor-type tyrosine-protein phosphatase N
    pfam11548
    Location:469 → 557
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:60 → 136
    RESP18; RESP18 domain

  2. XM_038448030.1 → XP_038303958.1  receptor-type tyrosine-protein phosphatase-like N isoform X1

    UniProtKB/TrEMBL
    A0A8C0LTE1, A0A8I3SCJ0, A0A8P0NGN1
    Related
    ENSCAFP00845041812.1, ENSCAFT00845053246.1
    Conserved Domains (3) summary
    cd14609
    Location:694 → 974
    R-PTP-N; PTP-like domain of receptor-type tyrosine-protein phosphatase N
    pfam11548
    Location:470 → 558
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:60 → 136
    RESP18; RESP18 domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049297.1 Alternate UMICH_Zoey_3.1

    Range
    25755175..25773586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038522016.1 → XP_038377944.1  receptor-type tyrosine-protein phosphatase-like N isoform X2

    Conserved Domains (3) summary
    cd14609
    Location:693 → 973
    R-PTP-N; PTP-like domain of receptor-type tyrosine-protein phosphatase N
    pfam11548
    Location:469 → 557
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:60 → 136
    RESP18; RESP18 domain

  2. XM_038522015.1 → XP_038377943.1  receptor-type tyrosine-protein phosphatase-like N isoform X1

    Conserved Domains (3) summary
    cd14609
    Location:694 → 974
    R-PTP-N; PTP-like domain of receptor-type tyrosine-protein phosphatase N
    pfam11548
    Location:470 → 558
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:60 → 136
    RESP18; RESP18 domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049778.1 Alternate UNSW_CanFamBas_1.0

    Range
    25690528..25708945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038650197.1 → XP_038506125.1  receptor-type tyrosine-protein phosphatase-like N isoform X2

    Conserved Domains (3) summary
    cd14609
    Location:693 → 973
    R-PTP-N; PTP-like domain of receptor-type tyrosine-protein phosphatase N
    pfam11548
    Location:469 → 557
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:60 → 136
    RESP18; RESP18 domain

  2. XM_038650196.1 → XP_038506124.1  receptor-type tyrosine-protein phosphatase-like N isoform X1

    Conserved Domains (3) summary
    cd14609
    Location:694 → 974
    R-PTP-N; PTP-like domain of receptor-type tyrosine-protein phosphatase N
    pfam11548
    Location:470 → 558
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:60 → 136
    RESP18; RESP18 domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049258.1 Alternate UU_Cfam_GSD_1.0

    Range
    25711218..25729647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038585823.1 → XP_038441751.1  receptor-type tyrosine-protein phosphatase-like N isoform X2

    UniProtKB/TrEMBL
    A0A8C0LTE1

  2. XM_038585822.1 → XP_038441750.1  receptor-type tyrosine-protein phosphatase-like N isoform X1

    UniProtKB/TrEMBL
    A0A8C0LTE1

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006619.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    26661448..26679881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_536080.7 → XP_536080.5  receptor-type tyrosine-protein phosphatase-like N isoform X2

    UniProtKB/TrEMBL
    A0A8C0LTE1, A0A8C0MY04
    Conserved Domains (3) summary
    cd14609
    Location:693 → 973
    R-PTP-N; PTP-like domain of receptor-type tyrosine-protein phosphatase N
    pfam11548
    Location:469 → 557
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:60 → 136
    RESP18; RESP18 domain

  2. XM_038463737.1 → XP_038319665.1  receptor-type tyrosine-protein phosphatase-like N isoform X1

    UniProtKB/TrEMBL
    A0A8C0LTE1, A0A8I3SCJ0, A0A8P0NGN1
    Conserved Domains (3) summary
    cd14609
    Location:694 → 974
    R-PTP-N; PTP-like domain of receptor-type tyrosine-protein phosphatase N
    pfam11548
    Location:470 → 558
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:60 → 136
    RESP18; RESP18 domain
Nucleotide Protein
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