bgcn benign gonial cell neoplasm [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: bgcnprovided by FlyBase
Official Full Name: benign gonial cell neoplasmprovided by FlyBase
Primary source: FLYBASE:FBgn0004581
Locus tag: Dmel_CG30170
See related: AllianceGenome:FB:FBgn0004581
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: b(2)cgn; b(2)gcn; bcgn; ben(2)gcn; Bgcn; BGCN; CG10330; cg10331; CG10331; CG30170; Dmel\CG30170; fs(2)eo-C; fs(2)eo6; fs(2)eoQS2; gcn; pep; PNBP
Summary: Enables translation repressor activity, mRNA regulatory element binding. Involved in several processes, including cell competition in a multicellular organism; germ-line stem cell population maintenance; and male germline stem cell symmetric division. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head; cystoblast; and gonad. Orthologous to human YTHDC2 (YTH domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 60A4-60A4; 2-105 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23853270..23858921, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19740793..19746444, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our in vivo and in vitro evidence illustrate that Tut acts with Bam, Bgcn to accurately coordinate proliferation and differentiation in Drosophila germline stem cell lineage.
Title: Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila.
Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early germline stem cell development, suggesting that this protein helps to repress the translation of nanos mRNA.
Title: Mei-p26 cooperates with Bam, Bgcn and Sxl to promote early germline development in the Drosophila ovary.
Bam/Bgcn complex plays a pivotal role in promoting stem cell differentiation.[Review]
Title: Bam and Bgcn in Drosophila germline stem cell differentiation.
The studies suggest that, in cystoblasts, Bam and Bgcn may directly inhibit Pum/Nos activity to promote differentiation of germ line stem cells.
Title: Direct inhibition of Pumilo activity by Bam and Bgcn in Drosophila germ line stem cell differentiation.
These observations suggest that Bam-Bgcn act together to antagonize Nos expression; thus, derepressing cystoblast-promoting factors; findings emphasize the importance of translational repression in balancing stem cell self-renewal and differentiation.
Title: Bam and Bgcn antagonize Nanos-dependent germ-line stem cell maintenance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
NOT enables helicase activity	IKR Inferred from Key Residues more info	PubMed
enables mRNA regulatory element binding translation repressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell competition in a multicellular organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cystoblast division	TAS Traceable Author Statement more info	PubMed
involved_in germ-line stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in male germline stem cell symmetric division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	HMP more info	PubMed

General protein information

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Preferred Names: benign gonial cell neoplasm

Names: CG30170-PA; CG30170-PB; benign gonial; benign gonial cell neoplasia; benign-(2)-gonial-cell-neoplasm; bgcn-PA; bgcn-PB; cell neoplasm; gonial-cell-neoplasm; peppercorn; putative nuclear binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

23853270..23858921 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299858.1 → NP_001286787.1 benign gonial cell neoplasm, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286787.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGG1

Conserved Domains (5) summary

smart00847
Location:689 → 758

HA2; Helicase associated domain (HA2) Add an annotation

cd00204
Location:407 → 460

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam07717
Location:818 → 940

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

pfam12796
Location:413 → 460

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:406 → 438

ANK; ANK repeat [structural motif]
NM_079108.3 → NP_523832.2 benign gonial cell neoplasm, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523832.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9W1I2, Q9W1I3

Related

FBpp0072141

Conserved Domains (6) summary

smart00847
Location:694 → 763

HA2; Helicase associated domain (HA2) Add an annotation

COG1643
Location:484 → 973

HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

cd00204
Location:407 → 460

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam07717
Location:823 → 945

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

pfam12796
Location:413 → 460

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:406 → 438

ANK; ANK repeat [structural motif]

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4LGG1		A0A0B4LGG1
A1YJU6		A1YJU6
A1YJU7		A1YJU7
A1YJU8		A1YJU8
A1YJV0		A1YJV0
A1YJV5		A1YJV5
A1YJV6		A1YJV6
A1YJW8		A1YJW8
A1YJW9		A1YJW9
A1YJX3		A1YJX3
A1YJX6		A1YJX6
Q8T4D2		Q8T4D2
Q9W1I2.2		Q9W1I2