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LEF1 lymphoid enhancer binding factor 1 [ Canis lupus familiaris (dog) ]

Gene ID: 478507, updated on 17-Aug-2024

Summary

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Official Symbol
LEF1provided by VGNC
Official Full Name
lymphoid enhancer binding factor 1provided by VGNC
Primary source
VGNC:VGNC:42630
See related
Ensembl:ENSCAFG00845029249
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See LEF1 in Genome Data Viewer
Location:
chromosome: 32
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 32 NC_051836.1 (28744891..28862596, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 32 NC_006614.4 (13389033..13506807)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 32 NC_049253.1 (11256345..11374064)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 32 NC_049292.1 (28737873..28855560, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 32 NC_049773.1 (28482671..28600623, complement)

Chromosome 32 - NC_051836.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily U member 1 Neighboring gene hydroxyacyl-CoA dehydrogenase Neighboring gene uncharacterized LOC111093692 Neighboring gene eukaryotic translation initiation factor 1-like Neighboring gene uncharacterized LOC119867199 Neighboring gene uncharacterized LOC106558120 Neighboring gene ribosomal protein L34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Helicobacter pylori suppresses glycogen synthase kinase 3beta to promote beta-catenin activity. Sokolova O, et al. J Biol Chem, 2008 Oct 24. PMID 18772141, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lymphoid enhancer-binding factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051836.1 Reference ROS_Cfam_1.0

    Range
    28744891..28862596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038444333.1 → XP_038300261.1  lymphoid enhancer-binding factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KAK4, A0A8C0TF83, A0A8P0P5R6
    Related
    ENSCAFP00845040605.1, ENSCAFT00845051755.1
    Conserved Domains (2) summary
    cd01388
    Location:299 → 370
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  2. XM_038444335.1 → XP_038300263.1  lymphoid enhancer-binding factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0TF83, A0A8P0P5R6
    Conserved Domains (2) summary
    cd01388
    Location:271 → 342
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  3. XM_038444334.1 → XP_038300262.1  lymphoid enhancer-binding factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0K845, A0A8C0THM5, A0A8C0Z3U9, A0A8P0ND48, A0A8P0NWB3
    Conserved Domains (2) summary
    cd01388
    Location:299 → 370
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  4. XM_038444336.1 → XP_038300264.1  lymphoid enhancer-binding factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KCJ9, A0A8C0PCJ9, A0A8I3Q609, A0A8P0T1R9
    Related
    ENSCAFP00845040648.1, ENSCAFT00845051803.1
    Conserved Domains (2) summary
    cd01388
    Location:271 → 342
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  5. XM_038444337.1 → XP_038300265.1  lymphoid enhancer-binding factor 1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0TG31, A0A8I3Q381
    Conserved Domains (2) summary
    cd01388
    Location:230 → 301
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:6 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding

  6. XM_038444338.1 → XP_038300266.1  lymphoid enhancer-binding factor 1 isoform X6

    UniProtKB/TrEMBL
    A0A8C0TG31, A0A8I3Q381
    Related
    ENSCAFP00845040668.1, ENSCAFT00845051827.1
    Conserved Domains (2) summary
    cd01388
    Location:230 → 301
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:6 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049292.1 Alternate UMICH_Zoey_3.1

    Range
    28737873..28855560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038518721.1 → XP_038374649.1  lymphoid enhancer-binding factor 1 isoform X1

    Conserved Domains (2) summary
    cd01388
    Location:299 → 370
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  2. XM_038518723.1 → XP_038374651.1  lymphoid enhancer-binding factor 1 isoform X3

    Conserved Domains (2) summary
    cd01388
    Location:271 → 342
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  3. XM_038518722.1 → XP_038374650.1  lymphoid enhancer-binding factor 1 isoform X2

    Conserved Domains (2) summary
    cd01388
    Location:299 → 370
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  4. XM_038518724.1 → XP_038374652.1  lymphoid enhancer-binding factor 1 isoform X4

    Conserved Domains (2) summary
    cd01388
    Location:271 → 342
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  5. XM_038518725.1 → XP_038374653.1  lymphoid enhancer-binding factor 1 isoform X5

    Conserved Domains (2) summary
    cd01388
    Location:230 → 301
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:6 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding

  6. XM_038518726.1 → XP_038374654.1  lymphoid enhancer-binding factor 1 isoform X6

    Conserved Domains (2) summary
    cd01388
    Location:230 → 301
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:6 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049773.1 Alternate UNSW_CanFamBas_1.0

    Range
    28482671..28600623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038646670.1 → XP_038502598.1  lymphoid enhancer-binding factor 1 isoform X1

    Conserved Domains (2) summary
    cd01388
    Location:299 → 370
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  2. XM_038646672.1 → XP_038502600.1  lymphoid enhancer-binding factor 1 isoform X3

    Conserved Domains (2) summary
    cd01388
    Location:271 → 342
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  3. XM_038646671.1 → XP_038502599.1  lymphoid enhancer-binding factor 1 isoform X2

    Conserved Domains (2) summary
    cd01388
    Location:299 → 370
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  4. XM_038646673.1 → XP_038502601.1  lymphoid enhancer-binding factor 1 isoform X4

    Conserved Domains (2) summary
    cd01388
    Location:271 → 342
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  5. XM_038646674.1 → XP_038502602.1  lymphoid enhancer-binding factor 1 isoform X5

    Conserved Domains (2) summary
    cd01388
    Location:230 → 301
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:6 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding

  6. XM_038646675.1 → XP_038502603.1  lymphoid enhancer-binding factor 1 isoform X6

    Conserved Domains (2) summary
    cd01388
    Location:230 → 301
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:6 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049253.1 Alternate UU_Cfam_GSD_1.0

    Range
    11256345..11374064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038581937.1 → XP_038437865.1  lymphoid enhancer-binding factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KAK4, A0A8C0TF83, A0A8P0P5R6
    Conserved Domains (2) summary
    cd01388
    Location:299 → 370
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  2. XM_038581938.1 → XP_038437866.1  lymphoid enhancer-binding factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0K845, A0A8C0THM5, A0A8C0Z3U9, A0A8P0ND48, A0A8P0NWB3
    Conserved Domains (2) summary
    cd01388
    Location:299 → 370
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  3. XM_038581939.1 → XP_038437867.1  lymphoid enhancer-binding factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0TF83, A0A8P0P5R6
    Conserved Domains (2) summary
    cd01388
    Location:271 → 342
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  4. XM_038581940.1 → XP_038437868.1  lymphoid enhancer-binding factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KCJ9, A0A8C0PCJ9, A0A8I3Q609, A0A8P0T1R9
    Conserved Domains (2) summary
    cd01388
    Location:271 → 342
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  5. XM_038581941.1 → XP_038437869.1  lymphoid enhancer-binding factor 1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0TG31, A0A8I3Q381
    Conserved Domains (2) summary
    cd01388
    Location:230 → 301
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:6 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding

  6. XM_038581942.1 → XP_038437870.1  lymphoid enhancer-binding factor 1 isoform X6

    UniProtKB/TrEMBL
    A0A8C0TG31, A0A8I3Q381
    Conserved Domains (2) summary
    cd01388
    Location:230 → 301
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:6 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006614.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    13389033..13506807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005639262.3 → XP_005639319.1  lymphoid enhancer-binding factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KAK4, A0A8C0TF83, A0A8P0P5R6
    Conserved Domains (2) summary
    cd01388
    Location:299 → 370
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  2. XM_858241.5 → XP_863334.2  lymphoid enhancer-binding factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0K845, A0A8C0THM5, A0A8C0Z3U9, A0A8P0ND48, A0A8P0NWB3
    Conserved Domains (2) summary
    cd01388
    Location:299 → 370
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  3. XM_858309.5 → XP_863402.1  lymphoid enhancer-binding factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0TF83, A0A8P0P5R6
    Conserved Domains (2) summary
    cd01388
    Location:271 → 342
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  4. XM_858284.5 → XP_863377.1  lymphoid enhancer-binding factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KCJ9, A0A8C0PCJ9, A0A8I3Q609, A0A8P0T1R9
    Conserved Domains (2) summary
    cd01388
    Location:271 → 342
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 214
    CTNNB1_binding; N-terminal CTNNB1 binding

  5. XM_038462024.1 → XP_038317952.1  lymphoid enhancer-binding factor 1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0TG31, A0A8I3Q381
    Conserved Domains (2) summary
    cd01388
    Location:230 → 301
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:6 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding

  6. XM_022413712.2 → XP_022269420.1  lymphoid enhancer-binding factor 1 isoform X6

    UniProtKB/TrEMBL
    A0A8C0TG31, A0A8I3Q381
    Conserved Domains (2) summary
    cd01388
    Location:230 → 301
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:6 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding
Nucleotide Protein
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