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SPP1 secreted phosphoprotein 1 [ Canis lupus familiaris (dog) ]

Gene ID: 478471, updated on 17-Aug-2024

Summary

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Official Symbol
SPP1provided by VGNC
Official Full Name
secreted phosphoprotein 1provided by VGNC
Primary source
VGNC:VGNC:46756
See related
Ensembl:ENSCAFG00845016131
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See SPP1 in Genome Data Viewer
Location:
chromosome: 32
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 32 NC_051836.1 (11406381..11414630)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 32 NC_006614.4 (30592131..30600371, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 32 NC_049253.1 (28630350..28638599, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 32 NC_049292.1 (11490535..11498773)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 32 NC_049773.1 (11316506..11324744)

Chromosome 32 - NC_051836.1Genomic Context describing neighboring genes Neighboring gene matrix extracellular phosphoglycoprotein Neighboring gene uncharacterized LOC111093643 Neighboring gene uncharacterized LOC111093685 Neighboring gene polycystin 2, transient receptor potential cation channel Neighboring gene SNW domain-containing protein 1-like Neighboring gene ATP binding cassette subfamily G member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Osteopontin in seminal plasma and sperm membrane of dogs. Souza FF, et al. Reprod Domest Anim, 2009 Jul. PMID 19754587
  2. Gene expression profile altered by orthodontic tooth movement during healing of surgical alveolar defect. Choi EK, et al. Am J Orthod Dentofacial Orthop, 2017 Jun. PMID 28554456
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional annotations of gene clusters based on differentially expressed genes among groups indicated that the gene expression profile of group DT6 had a stronger similarity to that of group D2 than to group D6. The genes participating in high woven-bone fraction in group DT6 could be identified as TNFSF11, MMP13, SPP1, and DMP1, which were verified by quantitative real-time polymerase chain reactions.
    Title: Gene expression profile altered by orthodontic tooth movement during healing of surgical alveolar defect.
  2. It was concluded that seminal plasma and sperm membranes from dogs contain different isoforms of osteopontin; further studies will be necessary to determine their function in this species.
    Title: Osteopontin in seminal plasma and sperm membrane of dogs.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ossification IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of bone resorption IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
osteopontin
Names
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051836.1 Reference ROS_Cfam_1.0

    Range
    11406381..11414630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038444088.1 → XP_038300016.1  osteopontin isoform X1

    UniProtKB/TrEMBL
    A0A8C0K4H1, A0A8C0PLS6, A0A8I3P1W2
    Related
    ENSCAFP00845022628.1, ENSCAFT00845028748.1
    Conserved Domains (1) summary
    pfam00865
    Location:21 → 299
    Osteopontin

  2. XM_038444089.1 → XP_038300017.1  osteopontin isoform X2

    UniProtKB/TrEMBL
    A0A8C0PHK1, A0A8I3S1Y5
    Related
    ENSCAFP00845022594.1, ENSCAFT00845028705.1
    Conserved Domains (1) summary
    pfam00865
    Location:21 → 272
    Osteopontin

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049292.1 Alternate UMICH_Zoey_3.1

    Range
    11490535..11498773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038518484.1 → XP_038374412.1  osteopontin isoform X1

    Conserved Domains (1) summary
    pfam00865
    Location:21 → 299
    Osteopontin

  2. XM_038518485.1 → XP_038374413.1  osteopontin isoform X2

    Conserved Domains (1) summary
    pfam00865
    Location:21 → 272
    Osteopontin

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049773.1 Alternate UNSW_CanFamBas_1.0

    Range
    11316506..11324744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038646420.1 → XP_038502348.1  osteopontin isoform X1

    Conserved Domains (1) summary
    pfam00865
    Location:21 → 299
    Osteopontin

  2. XM_038646421.1 → XP_038502349.1  osteopontin isoform X2

    Conserved Domains (1) summary
    pfam00865
    Location:21 → 272
    Osteopontin

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049253.1 Alternate UU_Cfam_GSD_1.0

    Range
    28630350..28638599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038582182.1 → XP_038438110.1  osteopontin isoform X1

    UniProtKB/TrEMBL
    A0A8C0K4H1, A0A8C0PLS6, A0A8I3P1W2
    Conserved Domains (1) summary
    pfam00865
    Location:21 → 299
    Osteopontin

  2. XM_038582183.1 → XP_038438111.1  osteopontin isoform X2

    UniProtKB/TrEMBL
    A0A8C0PHK1, A0A8I3S1Y5
    Conserved Domains (1) summary
    pfam00865
    Location:21 → 272
    Osteopontin

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006614.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    30592131..30600371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003434024.5 → XP_003434072.1  osteopontin isoform X1

    UniProtKB/TrEMBL
    A0A8P0NMW9
    Conserved Domains (1) summary
    pfam00865
    Location:21 → 299
    Osteopontin

  2. XM_003434023.5 → XP_003434071.1  osteopontin isoform X2

    UniProtKB/TrEMBL
    A0A8P0NUY5
    Conserved Domains (1) summary
    pfam00865
    Location:21 → 272
    Osteopontin
Nucleotide Protein
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