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KRT7 keratin 7 [ Canis lupus familiaris (dog) ]

Gene ID: 477602, updated on 5-Mar-2024

Summary

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Gene symbol
KRT7
Gene description
keratin 7
See related
Ensembl:ENSCAFG00845025459
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
CK7
Orthologs
human mouse all
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Genomic context

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See KRT7 in Genome Data Viewer
Location:
chromosome: 27
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (2811546..2826249, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (43426876..43441582)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (43825075..43839789)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (2828289..2843003, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (2814255..2828967, complement)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111092819 Neighboring gene keratin 88 Neighboring gene keratin, type II cuticular Hb1-like Neighboring gene keratin 80 Neighboring gene small integral membrane protein 41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative characterization of the canine normal prostate in intact and castrated animals. Lai CL, et al. Prostate, 2008 Apr 1. PMID 18213634
  2. Tenascin-C in chronic canine hepatitis: immunohistochemical localization and correlation with necro-inflammatory activity, fibrotic stage, and expression of alpha-smooth muscle actin, cytokeratin 7, and CD3+ cells. Mekonnen GA, et al. Vet Pathol, 2007 Nov. PMID 18039893
  3. Histopathological and immunohistochemical characterization of canine prostate cancer. Lai CL, et al. Prostate, 2008 Apr 1. PMID 18196537
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Immunohistochemically, 50% or more of the canine prostate cancer cases showed expression of PSA, PSMA, UPIII, CK7, CK5, CK14, and CK18.
    Title: Histopathological and immunohistochemical characterization of canine prostate cancer.
  2. Canine prostate epithelium displayed a highly differentiated character, with most cells expressing CK18 and PSA. After castration, prostate epithelium regressed, and the tubule cells showed a ductal phenotype of CK5, CK18, and CK7.
    Title: Comparative characterization of the canine normal prostate in intact and castrated animals.
  3. This study reported the correlation of tenascin-C with the inflammatory activity and expression of alpha-smooth muscle actin (alpha-SMA), cytokeratin 7 (CK7), and CD3+ T-lymphocytes in canine chronic hepatitis.
    Title: Tenascin-C in chronic canine hepatitis: immunohistochemical localization and correlation with necro-inflammatory activity, fibrotic stage, and expression of alpha-smooth muscle actin, cytokeratin 7, and CD3+ cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables structural constituent of skin epidermis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intermediate filament organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
keratin, type II cytoskeletal 7
Names
cytokeratin 7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    2811546..2826249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038438118.1 → XP_038294046.1  keratin, type II cytoskeletal 7

    UniProtKB/TrEMBL
    A0A8C0P5E1, A0A8C0Z0X3, A0A8I3PRA8
    Related
    ENSCAFP00845035711.1, ENSCAFT00845045530.1
    Conserved Domains (2) summary
    pfam00038
    Location:90 → 402
    Filament; Intermediate filament protein
    pfam16208
    Location:10 → 87
    Keratin_2_head; Keratin type II head

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    2828289..2843003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038512813.1 → XP_038368741.1  keratin, type II cytoskeletal 7

    Conserved Domains (2) summary
    pfam00038
    Location:90 → 402
    Filament; Intermediate filament protein
    pfam16208
    Location:10 → 87
    Keratin_2_head; Keratin type II head

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    2814255..2828967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038640575.1 → XP_038496503.1  keratin, type II cytoskeletal 7

    Conserved Domains (2) summary
    pfam00038
    Location:90 → 402
    Filament; Intermediate filament protein
    pfam16208
    Location:10 → 87
    Keratin_2_head; Keratin type II head

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    43825075..43839789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038577729.1 → XP_038433657.1  keratin, type II cytoskeletal 7

    UniProtKB/TrEMBL
    A0A8C0P5E1, A0A8C0Z0X3, A0A8I3PRA8
    Conserved Domains (2) summary
    pfam00038
    Location:90 → 402
    Filament; Intermediate filament protein
    pfam16208
    Location:10 → 87
    Keratin_2_head; Keratin type II head

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    43426876..43441582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038460138.1 → XP_038316066.1  keratin, type II cytoskeletal 7

    UniProtKB/TrEMBL
    A0A8C0JLA5, A0A8C0P5E1, A0A8P0PR78
    Conserved Domains (2) summary
    pfam00038
    Location:90 → 402
    Filament; Intermediate filament protein
    pfam16208
    Location:10 → 87
    Keratin_2_head; Keratin type II head
Nucleotide Protein
Heading Accession and Version

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