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TOP1 DNA topoisomerase I [ Canis lupus familiaris (dog) ]

Gene ID: 477229, updated on 17-Aug-2024

Summary

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Official Symbol
TOP1provided by VGNC
Official Full Name
DNA topoisomerase Iprovided by VGNC
Primary source
VGNC:VGNC:49631
See related
Ensembl:ENSCAFG00845029978
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
TOP
Orthologs
human mouse all
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Genomic context

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See TOP1 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
21
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (29781234..29872485)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (28720984..28812380)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (29650217..29741420)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (29049969..29141401)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (29153861..29245250)

Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene MAF bZIP transcription factor B Neighboring gene uncharacterized LOC102152405 Neighboring gene SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-like Neighboring gene uncharacterized LOC102152517 Neighboring gene phospholipase C gamma 1 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene uncharacterized LOC111092095

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library. Li R, et al. Genomics, 1999 May 15. PMID 10331940
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA topological change IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA topoisomerase 1
Names
topoisomerase (DNA) I
topoisomerase I
XP_038289760.1
XP_038364906.1
XP_038428244.1
XP_038492497.1
XP_534420.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051828.1 Reference ROS_Cfam_1.0

    Range
    29781234..29872485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038433832.1 → XP_038289760.1  DNA topoisomerase 1

    UniProtKB/TrEMBL
    A0A8C0KFK0, A0A8C0MIF6, A0A8I3SCI3
    Related
    ENSCAFP00845041728.1, ENSCAFT00845053140.1
    Conserved Domains (2) summary
    smart00435
    Location:365 → 742
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam02919
    Location:220 → 434
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049284.1 Alternate UMICH_Zoey_3.1

    Range
    29049969..29141401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038508978.1 → XP_038364906.1  DNA topoisomerase 1

    Conserved Domains (2) summary
    smart00435
    Location:365 → 742
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam02919
    Location:220 → 434
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

    Range
    29153861..29245250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038636569.1 → XP_038492497.1  DNA topoisomerase 1

    Conserved Domains (2) summary
    smart00435
    Location:365 → 742
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam02919
    Location:220 → 434
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

    Range
    29650217..29741420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038572316.1 → XP_038428244.1  DNA topoisomerase 1

    UniProtKB/TrEMBL
    A0A8C0KFK0, A0A8C0T9U8, A0A8P0SE48
    Conserved Domains (2) summary
    smart00435
    Location:365 → 742
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam02919
    Location:220 → 434
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    28720984..28812380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_534420.7 → XP_534420.3  DNA topoisomerase 1

    UniProtKB/TrEMBL
    A0A8C0KFK0, A0A8C0T9U8, A0A8P0SE48
    Conserved Domains (2) summary
    smart00435
    Location:365 → 742
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam02919
    Location:220 → 434
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
Nucleotide Protein
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