MKRN2 makorin ring finger protein 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MKRN2provided by VGNC
Official Full Name: makorin ring finger protein 2provided by VGNC
Primary source: VGNC:VGNC:43252
See related: Ensembl:ENSCAFG00845028765
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	20	NC_051824.1 (6000763..6030623, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	20	NC_006602.4 (6009205..6039062, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	20	NC_049241.1 (6045895..6075772, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	20	NC_049280.1 (5716930..5746803, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	20	NC_049761.1 (6070843..6100697, complement)

Chromosome 20 - NC_051824.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: probable E3 ubiquitin-protein ligase makorin-2

XP_005632195.1

EC 2.3.2.27

XP_013977072.1

EC 2.3.2.27

XP_038282824.1

EC 2.3.2.27

XP_038282825.1

EC 2.3.2.27

XP_038282827.1

EC 2.3.2.27

XP_038311912.1

EC 2.3.2.27

XP_038358621.1

EC 2.3.2.27

XP_038358622.1

EC 2.3.2.27

XP_038358623.1

EC 2.3.2.27

XP_038421539.1

EC 2.3.2.27

XP_038421540.1

EC 2.3.2.27

XP_038421541.1

EC 2.3.2.27

XP_038485672.1

EC 2.3.2.27

XP_038485673.1

EC 2.3.2.27

XP_038485674.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051824.1 Reference ROS_Cfam_1.0

Range

6000763..6030623 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038426896.1 → XP_038282824.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X1

UniProtKB/TrEMBL

A0A8C0K1V3, A0A8C0PD23, A0A8C0TDW1, A0A8I3PYL3, A0A8I3Q596

Related

ENSCAFP00845039840.1, ENSCAFT00845050821.1

Conserved Domains (4) summary

PHA03096
Location:178 → 327

PHA03096; p28-like protein; Provisional

cd16731
Location:235 → 292

RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

pfam18044
Location:6 → 27

zf-CCCH_4; CCCH-type zinc finger

pfam18345
Location:37 → 55

zf_CCCH_4; Zinc finger domain
XM_038426897.1 → XP_038282825.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X2

UniProtKB/TrEMBL

A0A8C0PD23, A0A8C0TGL6, A0A8I3Q596

Related

ENSCAFP00845039889.1, ENSCAFT00845050882.1

Conserved Domains (3) summary

PHA03096
Location:174 → 323

PHA03096; p28-like protein; Provisional

cd16731
Location:231 → 288

RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

pfam18345
Location:33 → 51

zf_CCCH_4; Zinc finger domain
XM_038426899.1 → XP_038282827.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X3

UniProtKB/TrEMBL

A0A8C0PD23, A0A8I3Q596

Conserved Domains (3) summary

PHA03096
Location:167 → 316

PHA03096; p28-like protein; Provisional

cd16731
Location:224 → 281

RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

pfam18345
Location:26 → 44

zf_CCCH_4; Zinc finger domain

Alternate UMICH_Zoey_3.1

Genomic

NC_049280.1 Alternate UMICH_Zoey_3.1

Range

5716930..5746803 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038502693.1 → XP_038358621.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X1

Conserved Domains (4) summary

PHA03096
Location:178 → 327

PHA03096; p28-like protein; Provisional

cd16731
Location:235 → 292

RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

pfam18044
Location:6 → 27

zf-CCCH_4; CCCH-type zinc finger

pfam18345
Location:37 → 55

zf_CCCH_4; Zinc finger domain
XM_038502694.1 → XP_038358622.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X2

Conserved Domains (3) summary

PHA03096
Location:174 → 323

PHA03096; p28-like protein; Provisional

cd16731
Location:231 → 288

RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

pfam18345
Location:33 → 51

zf_CCCH_4; Zinc finger domain
XM_038502695.1 → XP_038358623.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X3

Conserved Domains (3) summary

PHA03096
Location:167 → 316

PHA03096; p28-like protein; Provisional

cd16731
Location:224 → 281

RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

pfam18345
Location:26 → 44

zf_CCCH_4; Zinc finger domain

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049761.1 Alternate UNSW_CanFamBas_1.0

Range

6070843..6100697 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038629744.1 → XP_038485672.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X1

Conserved Domains (4) summary

PHA03096
Location:178 → 327

PHA03096; p28-like protein; Provisional

cd16731
Location:235 → 292

RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

pfam18044
Location:6 → 27

zf-CCCH_4; CCCH-type zinc finger

pfam18345
Location:37 → 55

zf_CCCH_4; Zinc finger domain
XM_038629745.1 → XP_038485673.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X2

Conserved Domains (3) summary

PHA03096
Location:174 → 323

PHA03096; p28-like protein; Provisional

cd16731
Location:231 → 288

RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

pfam18345
Location:33 → 51

zf_CCCH_4; Zinc finger domain
XM_038629746.1 → XP_038485674.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X3

Conserved Domains (3) summary

PHA03096
Location:167 → 316

PHA03096; p28-like protein; Provisional

cd16731
Location:224 → 281

RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

pfam18345
Location:26 → 44

zf_CCCH_4; Zinc finger domain

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049241.1 Alternate UU_Cfam_GSD_1.0

Range

6045895..6075772 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038565611.1 → XP_038421539.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X1

UniProtKB/TrEMBL

A0A8C0PD23, A0A8I3Q596
XM_038565612.1 → XP_038421540.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X2

UniProtKB/TrEMBL

A0A8C0PD23, A0A8I3Q596
XM_038565613.1 → XP_038421541.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X3

UniProtKB/TrEMBL

A0A8C0PD23, A0A8I3Q596

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

6009205..6039062 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005632138.4 → XP_005632195.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X1

UniProtKB/TrEMBL

A0A8C0K1V3, A0A8C0PD23, A0A8C0TDW1, A0A8I3PYL3, A0A8I3Q596

Conserved Domains (4) summary

PHA03096
Location:178 → 327

PHA03096; p28-like protein; Provisional

cd16731
Location:235 → 292

RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

pfam18044
Location:6 → 27

zf-CCCH_4; CCCH-type zinc finger

pfam18345
Location:37 → 55

zf_CCCH_4; Zinc finger domain
XM_014121597.3 → XP_013977072.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X2

UniProtKB/TrEMBL

A0A8C0PD23, A0A8C0TGL6, A0A8I3Q596

Conserved Domains (3) summary

PHA03096
Location:174 → 323

PHA03096; p28-like protein; Provisional

cd16731
Location:231 → 288

RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

pfam18345
Location:33 → 51

zf_CCCH_4; Zinc finger domain
XM_038455984.1 → XP_038311912.1 probable E3 ubiquitin-protein ligase makorin-2 isoform X3

UniProtKB/TrEMBL

A0A8C0PD23, A0A8I3Q596

Conserved Domains (3) summary

PHA03096
Location:167 → 316

PHA03096; p28-like protein; Provisional

cd16731
Location:224 → 281

RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

pfam18345
Location:26 → 44

zf_CCCH_4; Zinc finger domain