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ASB3 ankyrin repeat and SOCS box containing 3 [ Canis lupus familiaris (dog) ]

Gene ID: 474592, updated on 17-Aug-2024

Summary

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Official Symbol
ASB3provided by VGNC
Official Full Name
ankyrin repeat and SOCS box containing 3provided by VGNC
Primary source
VGNC:VGNC:108201
See related
Ensembl:ENSCAFG00845007688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ASB3 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (55703328..55814197, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (54664431..54738630, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (55977514..56051739, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (55404712..55478696, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (55690487..55764686, complement)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119873674 Neighboring gene dynein light chain 1, cytoplasmic-like Neighboring gene ChaC glutathione specific gamma-glutamylcyclotransferase 2 Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene uncharacterized LOC119873778

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205055.1 → NP_001191984.1  ankyrin repeat and SOCS box protein 3

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000358
    UniProtKB/TrEMBL
    A0A8C0PR50, A0A8I3N942, A0A8P0PFK3
    Related
    ENSCAFP00845010589.1, ENSCAFT00845013637.1
    Conserved Domains (4) summary
    cd00204
    Location:146 → 267
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03722
    Location:458 → 508
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    pfam12796
    Location:83 → 176
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:146 → 176
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    55703328..55814197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038678778.1 → XP_038534706.1  ankyrin repeat and SOCS box protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0PR50, A0A8I3N905
    Related
    ENSCAFP00845010529.1, ENSCAFT00845013562.1
    Conserved Domains (4) summary
    cd03722
    Location:376 → 426
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:42 → 77
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:16 → 109
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:197 → 303
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_038678779.1 → XP_038534707.1  ankyrin repeat and SOCS box protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0PR50
    Conserved Domains (4) summary
    cd03722
    Location:373 → 423
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:147 → 177
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:217 → 310
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:22 → 238
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_038678774.1 → XP_038534702.1  ankyrin repeat and SOCS box protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PR50, A0A8C0SSW7, A0A8I3N6M8
    Related
    ENSCAFP00845010507.1, ENSCAFT00845013538.1
    Conserved Domains (4) summary
    cd03722
    Location:459 → 509
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:147 → 177
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:217 → 310
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:22 → 238
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_038678775.1 → XP_038534703.1  ankyrin repeat and SOCS box protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PR50, A0A8C0SSW7, A0A8I3N6M8
    Conserved Domains (4) summary
    cd03722
    Location:459 → 509
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:147 → 177
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:217 → 310
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:22 → 238
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_038678777.1 → XP_038534705.1  ankyrin repeat and SOCS box protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PR50, A0A8C0SSW7, A0A8I3N6M8
    Conserved Domains (4) summary
    cd03722
    Location:459 → 509
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:147 → 177
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:217 → 310
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:22 → 238
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_038678776.1 → XP_038534704.1  ankyrin repeat and SOCS box protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PR50, A0A8C0SSW7, A0A8I3N6M8
    Conserved Domains (4) summary
    cd03722
    Location:459 → 509
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:147 → 177
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:217 → 310
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:22 → 238
    Ank_2; Ankyrin repeats (3 copies)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    55404712..55478696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    55690487..55764686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    55977514..56051739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    54664431..54738630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
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