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magi1b membrane associated guanylate kinase, WW and PDZ domain containing 1b [ Danio rerio (zebrafish) ]

Gene ID: 474349, updated on 10-Sep-2024

Summary

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Official Symbol
magi1bprovided by ZNC
Official Full Name
membrane associated guanylate kinase, WW and PDZ domain containing 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5110
See related
Ensembl:ENSDARG00000003169 AllianceGenome:ZFIN:ZDB-GENE-030131-5110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
magi1; MAGI-1; baiap1; fe48b06; wu:fe48b06; wu:fj98f08
Summary
Predicted to enable molecular adaptor activity. Predicted to be involved in signal transduction. Predicted to be located in bicellular tight junction and membrane. Predicted to be active in cell-cell junction and cytoplasm. Is expressed in blastoderm. Orthologous to human MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (18873096..19090812)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (18710760..18928462)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b Neighboring gene putative homeodomain transcription factor 1 Neighboring gene rhodopsin, like Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differential transcript isoform usage pre- and post-zygotic genome activation in zebrafish. Aanes H, et al. BMC Genomics, 2013 May 15. PMID 23676078, Free PMC Article
  2. Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression. Herrero-Turrión MJ, et al. BMC Genomics, 2014 Oct 8. PMID 25294025, Free PMC Article
  3. Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development. Wright GJ, et al. Development, 2004 Nov. PMID 15509766
  4. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article
  5. Analysis and functional evaluation of the hair-cell transcriptome. McDermott BM Jr, et al. Proc Natl Acad Sci U S A, 2007 Jul 10. PMID 17606911, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1b
Names
BAI1-associated protein 1
membrane associated guanylate kinase, WW and PDZ domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007063.2 → NP_001007064.2  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1b

    Status: VALIDATED

    Source sequence(s)
    AL935040, BX294166, CR932038
    UniProtKB/TrEMBL
    A0A8M1N2L7, F1QZB9
    Related
    ENSDARP00000094744.5, ENSDART00000103969.6

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    18873096..19090812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155831.4 → XP_005155888.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8M2B2I9
    Conserved Domains (8) summary
    smart00456
    Location:301 → 332
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:473 → 554
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:984 → 1067
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:361 → 390
    WW; WW domain
    pfam08648
    Location:1341 → 1444
    DUF1777; Protein of unknown function (DUF1777)
    pfam12871
    Location:1357 → 1441
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    pfam16666
    Location:726 → 818
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:117 → 242
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. XM_009305956.3 → XP_009304231.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8M3AXK8
    Conserved Domains (6) summary
    smart00456
    Location:301 → 332
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:473 → 554
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:984 → 1079
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:361 → 390
    WW; WW domain
    pfam16666
    Location:726 → 818
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:117 → 242
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  3. XM_005155829.4 → XP_005155886.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B284
    Conserved Domains (8) summary
    smart00456
    Location:301 → 332
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:473 → 554
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:984 → 1079
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:361 → 390
    WW; WW domain
    pfam08648
    Location:1353 → 1456
    DUF1777; Protein of unknown function (DUF1777)
    pfam12871
    Location:1369 → 1453
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    pfam16666
    Location:726 → 818
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:117 → 242
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  4. XM_005155830.4 → XP_005155887.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B2Q4
    Conserved Domains (8) summary
    smart00456
    Location:301 → 332
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:473 → 554
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:982 → 1077
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:361 → 390
    WW; WW domain
    pfam08648
    Location:1351 → 1454
    DUF1777; Protein of unknown function (DUF1777)
    pfam12871
    Location:1367 → 1451
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    pfam16666
    Location:726 → 816
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:117 → 242
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  5. XM_009305951.3 → XP_009304226.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AXI7
    Conserved Domains (8) summary
    smart00456
    Location:301 → 332
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:467 → 548
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:978 → 1073
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:361 → 390
    WW; WW domain
    pfam08648
    Location:1347 → 1450
    DUF1777; Protein of unknown function (DUF1777)
    pfam12871
    Location:1363 → 1447
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    pfam16666
    Location:720 → 812
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:117 → 242
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  6. XM_009305953.3 → XP_009304228.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8M3B402
    Conserved Domains (8) summary
    smart00456
    Location:301 → 332
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:428 → 509
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:939 → 1034
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:361 → 390
    WW; WW domain
    pfam08648
    Location:1308 → 1411
    DUF1777; Protein of unknown function (DUF1777)
    pfam12871
    Location:1324 → 1408
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    pfam16666
    Location:681 → 773
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:117 → 242
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  7. XM_021479602.1 → XP_021335277.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PUV4
    Conserved Domains (9) summary
    smart00456
    Location:301 → 332
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:461 → 542
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:972 → 1067
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:349 → 378
    WW; WW domain
    pfam08648
    Location:1349 → 1437
    DUF1777; Protein of unknown function (DUF1777)
    pfam16663
    Location:197 → 256
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:714 → 806
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:117 → 242
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    cl28033
    Location:1217 → 1530
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  8. XM_005155835.4 → XP_005155892.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A8M2B1V1
    Conserved Domains (4) summary
    cd00992
    Location:277 → 372
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08648
    Location:646 → 749
    DUF1777; Protein of unknown function (DUF1777)
    pfam15670
    Location:688 → 738
    Spem1; Spermatid maturation protein 1
    pfam16666
    Location:21 → 111
    MAGI_u5; Unstructured region on MAGI

  9. XM_005155834.4 → XP_005155891.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8M2B1Z1
    Conserved Domains (4) summary
    cd00992
    Location:282 → 377
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08648
    Location:651 → 754
    DUF1777; Protein of unknown function (DUF1777)
    pfam15670
    Location:693 → 743
    Spem1; Spermatid maturation protein 1
    pfam16666
    Location:25 → 116
    MAGI_u5; Unstructured region on MAGI
Nucleotide Protein
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