prrc1 proline-rich coiled-coil 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prrc1provided by ZNC
Official Full Name: proline-rich coiled-coil 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-041024-9
See related: Ensembl:ENSDARG00000044304 AllianceGenome:ZFIN:ZDB-GENE-041024-9
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mys; SAG20; fi37a08; t2gtl20; id:ibd5136; wu:fi37a08; zgc:103484
Summary: Enables protein kinase A regulatory subunit binding activity. Acts upstream of or within activation of protein kinase A activity; epithelial structure maintenance; and somite specification. Located in Golgi apparatus. Is expressed in several structures, including axis; early embryonic cell; gonad; paraxial mesoderm; and tail bud. Orthologous to human PRRC1 (proline rich coiled-coil 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (16165532..16186691)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (16207381..16228572)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results demonstrate that PKA activity regulated by Mys is indispensable for negative regulation of the Hh signaling pathway in Hh-responsive cells.
Title: Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate development.

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General gene information

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Markers

fd50h08.x1 (e-PCR)
- UniSTS:195590

fi37a08.x1 (e-PCR)
- UniSTS:204572

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A regulatory subunit binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of protein kinase A activity	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial structure maintenance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somite specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein PRRC1

Names: misty somites; proline-rich and coiled-coil-containing protein 1; protein misty somites; tol2 transposon-derived gene trap locus 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.