sra sarah [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sraprovided by FlyBase
Official Full Name: sarahprovided by FlyBase
Primary source: FLYBASE:FBgn0086370
Locus tag: Dmel_CG6072
See related: AllianceGenome:FB:FBgn0086370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 89B; 89B11; anon-WO0118547.92; anon-WO0172774.10; CG6072; Dmel\CG6072; l(3)05203; nebula; nla; Sarah; Sra
Summary: Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity. Involved in several processes, including learning or memory; regulation of female receptivity, post-mating; and single fertilization. Located in mitochondrial matrix and nucleus. Is expressed in adult mushroom body; eye disc; organism; and pole plasm. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human RCAN3 (RCAN family member 3); RCAN1 (regulator of calcineurin 1); and RCAN2 (regulator of calcineurin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 89B7-89B7; 3-58 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (16186999..16197584)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (12012721..12023306)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that sra negatively regulates calcineurin by cell-autonomously titrating calcineurin-dependent stabilization of PER and TIM proteins, thereby sustaining high-amplitude behavioral rhythms in Drosophila.
Title: High-Amplitude Circadian Rhythms in Drosophila Driven by Calcineurin-Mediated Post-translational Control of sarah.
sra overexpression augments Abeta42 cytotoxicity in Drosophila.
Title: The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease.
Our data further suggest that upregulation of Nebula/DSCR1 is neuroprotective in the presence of APP upregulation and provides evidence for calcineurin inhibition as a novel target for therapeutic intervention of Alzheimer's disease .
Title: Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling.
findings suggest a mechanism in which Shaggy/GSK-3beta activates calcineurin through Sarah phosphorylation on egg activation in Drosophila
Title: Shaggy/glycogen synthase kinase 3β and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis.
Calcineurin and its regulation by Sra are required for normal sleep in Drosophila
Title: Calcineurin and its regulator sra/DSCR1 are essential for sleep in Drosophila.
we describe a novel role of sra in Drosophila male courtship behavior
Title: The Drosophila calcineurin regulator, Sarah, is involved in male courtship.
Findings imply that restoring the level of any one of these genes dap160/itsn1, synj/synj1, and nla/dscr1 may reduce endocytic defects seen in DS.
Title: Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome.
both nebula loss-of-function and overexpression mutants exhibit severe learning defects that are attributed by biochemical perturbations rather than maldevelopment of the brain
Title: The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1629 (e-PCR)
- UniSTS:54297

Dm2160 (e-PCR)
- UniSTS:44071

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transporter activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in egg activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male pronucleus assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of female receptivity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of female receptivity, post-mating	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sarah

Names: CG6072-PA; CG6072-PB; lethal (3) 05203; nebula; sara; sra-PA; sra-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

16186999..16197584

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079654.3 → NP_524378.1 sarah, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524378.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V391, Q9XZL8

UniProtKB/TrEMBL

A0A0B4LHI3

Related

FBpp0082709

Conserved Domains (1) summary

cl17169
Location:127 → 265

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001300432.1 → NP_001287361.1 sarah, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287361.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V391, Q9XZL8

UniProtKB/TrEMBL

A0A0B4LHI3

Conserved Domains (1) summary

cl17169
Location:127 → 265

RRM_SF; RNA recognition motif (RRM) superfamily