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DRG1 developmentally regulated GTP binding protein 1 [ Homo sapiens (human) ]

Gene ID: 4733, updated on 7-Apr-2024

Summary

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Official Symbol
DRG1provided by HGNC
Official Full Name
developmentally regulated GTP binding protein 1provided by HGNC
Primary source
HGNC:HGNC:3029
See related
Ensembl:ENSG00000185721 MIM:603952; AllianceGenome:HGNC:3029
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEDD3; TANALS
Summary
Enables several functions, including GTPase activity; identical protein binding activity; and potassium ion binding activity. Involved in positive regulation of microtubule polymerization and regulation of mitotic spindle assembly. Located in cytosol and nuclear body. Part of polysome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 112.9), thyroid (RPKM 23.8) and 24 other tissues See more
Orthologs
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Genomic context

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See DRG1 in Genome Data Viewer
Location:
22q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (31399604..31434452)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (31864208..31899052)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31795590..31830438)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13630 Neighboring gene long intergenic non-protein coding RNA 1521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13631 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:31795617-31796522 Neighboring gene RNA, U6 small nuclear 338, pseudogene Neighboring gene eukaryotic translation initiation factor 4E nuclear import factor 1 Neighboring gene H3K27ac hESC enhancers GRCh37_chr22:31885137-31885760 and GRCh37_chr22:31885761-31886383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18858 Neighboring gene RNA, U6 small nuclear 28, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13635 Neighboring gene SFI1 centrin binding protein Neighboring gene H2A.Z histone pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structure and function of cancer-related developmentally regulated GTP-binding protein 1 (DRG1) is conserved between sponges and humans. Beljan S, et al. Sci Rep, 2022 Jul 5. PMID 35790840, Free PMC Article
  2. DRG1 is a potential oncogene in lung adenocarcinoma and promotes tumor progression via spindle checkpoint signaling regulation. Lu L, et al. Oncotarget, 2016 Nov 8. PMID 27626498, Free PMC Article
  3. Identification of DRG-1 As a Melanoma-Associated Antigen Recognized by CD4+ Th1 Cells. Kiniwa Y, et al. PLoS One, 2015. PMID 25993655, Free PMC Article
  4. Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression. Bandyopadhyay S, et al. Oncogene, 2004 Jul 22. PMID 15184886
  5. Developmentally regulated GTPases: structure, function and roles in disease. Westrip CAE, et al. Cell Mol Life Sci, 2021 Dec. PMID 34664086, Free PMC Article

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of DRG1, encoding a translation factor GTPase, causes a recessive neurodevelopmental disorder.
    Title: Inactivation of DRG1, encoding a translation factor GTPase, causes a recessive neurodevelopmental disorder.
  2. Structure and function of cancer-related developmentally regulated GTP-binding protein 1 (DRG1) is conserved between sponges and humans.
    Title: Structure and function of cancer-related developmentally regulated GTP-binding protein 1 (DRG1) is conserved between sponges and humans.
  3. DRG1 Maintains Intestinal Epithelial Cell Junctions and Barrier Function by Regulating RAC1 Activity in Necrotizing Enterocolitis.
    Title: DRG1 Maintains Intestinal Epithelial Cell Junctions and Barrier Function by Regulating RAC1 Activity in Necrotizing Enterocolitis.
  4. Developmentally regulated GTPases: structure, function and roles in disease.
    Title: Developmentally regulated GTPases: structure, function and roles in disease.
  5. m6A-dependent up-regulation of DRG1 by METTL3 and ELAVL1 promotes growth, migration, and colony formation in osteosarcoma.
    Title: m6A-dependent up-regulation of DRG1 by METTL3 and ELAVL1 promotes growth, migration, and colony formation in osteosarcoma.
  6. In vitro, DRG1 can diffuse on microtubules, promote their polymerization, drive microtubule formation into bundles, and stabilize microtubules. HeLa cells with reduced DRG1 levels show delayed progression from prophase to anaphase because spindle formation is slowed down.
    Title: Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics.
  7. DRG1 was an important protein involved in spindle checkpoint signaling, and elevated levels of DRG1 caused lung adenocarcinoma and taxol resistance.
    Title: DRG1 is a potential oncogene in lung adenocarcinoma and promotes tumor progression via spindle checkpoint signaling regulation.
  8. DRG-1 plays an important role in melanoma cell growth and transformation, indicating that DRG1 may represent a novel target for CD4(+) T cell-mediated immunotherapy in melanoma.
    Title: Identification of DRG-1 As a Melanoma-Associated Antigen Recognized by CD4+ Th1 Cells.
  9. Lerepo4 action leaves Drg1 affinity for nucleotides unaffected, feasibly favoring a switch I reorientation, mainly via the TGS domain.
    Title: Human Drg1 is a potassium-dependent GTPase enhanced by Lerepo4.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: A common variant in DRD3 receptor is associated with autism spectrum disorder.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Tan-Almurshedi syndrome
MedGen: CN375863 OMIM: 620641 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify developmentally regulated GTP binding protein 1 (DRG1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify developmentally regulated GTP binding protein 1 (DRG1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify developmentally regulated GTP binding protein 1 (DRG1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify developmentally regulated GTP binding protein 1 (DRG1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp434N1827

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
developmentally-regulated GTP-binding protein 1
Names
DRG-1
NEDD-3
TRAFAC GTPase DRG1
neural precursor cell expressed developmentally down-regulated protein 3
neural precursor cell expressed, developmentally down-regulated 3
translation factor GTPase DRG1
NP_004138.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004147.4 → NP_004138.1  developmentally-regulated GTP-binding protein 1

    See identical proteins and their annotated locations for NP_004138.1

    Status: VALIDATED

    Source sequence(s)
    AL096701, BC019285, BU584654
    Consensus CDS
    CCDS13897.1
    UniProtKB/Swiss-Prot
    B2RDS8, Q6FGP8, Q8WW69, Q9UGF2, Q9Y295
    Related
    ENSP00000329715.4, ENST00000331457.9
    Conserved Domains (1) summary
    COG1163
    Location:1 → 367
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    31399604..31434452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    31864208..31899052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y295.1 GenPept UniProtKB/Swiss-Prot:Q9Y295

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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