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POLY polyprotein [ Saint Louis encephalitis virus ]

Gene ID: 4712266, updated on 22-Sep-2023

Summary

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Gene symbol
POLY
Gene description
polyprotein
Locus tag
SLEV_gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Saint Louis encephalitis virus (strain: Kern217)
Lineage
Viruses; Riboviria; Flaviviridae; Flavivirus
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Genomic context

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Sequence:
NC_007580.2 (99..10391)

NC_007580.2Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007580.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the St. Louis encephalitis virus postfusion envelope trimer. Luca VC, et al. J Virol, 2013 Jan. PMID 23115296, Free PMC Article
  2. Cell-specific adaptation of two flaviviruses following serial passage in mosquito cell culture. Ciota AT, et al. Virology, 2007 Jan 20. PMID 16963095, Free PMC Article
  3. Partial N-terminal amino acid sequences of three nonstructural proteins of two flaviviruses. Rice CM, et al. Virology, 1986 May. PMID 3008425
  4. Amino-terminal amino acid sequences of structural proteins of three flaviviruses. Bell JR, et al. Virology, 1985 May. PMID 2998002
  5. Production of recombinant NS1 protein and its possible use in encephalitic flavivirus differential diagnosis. Lorch MS, et al. Protein Expr Purif, 2019 Jan. PMID 30125621

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conserved NS1 protein is species-specific for Saint Louis Encephalitis Virus and West Nile virus.
    Title: Production of recombinant NS1 protein and its possible use in encephalitic flavivirus differential diagnosis.
  2. Domains II and III (DII and DIII) of St. Louis encephalitis virus E protein also adopt different angles relative to DI, which suggests that the DI-DII joint may accommodate spheroidal motions.[E]
    Title: Structure of the St. Louis encephalitis virus postfusion envelope trimer.
  3. Structural protein, prME, dictates the growth differences of St Louis encephalitis virus and West Nile virus.
    Title: Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes.
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General protein information

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Preferred Names
polyprotein
Names
anchored capsid protein anchC
core protein C
membrane glycoprotein precursor prM
protein pr
membrane glycoprotein M
envelope protein E
nonstructural protein NS1
nonstructural protein NS2A
nonstructural protein NS2B
nonstructural protein NS3
nonstructural protein NS4A
protein 2K
nonstructural protein NS4B
RNA-dependent RNA polymerase NS5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007580.2 Reference assembly

    Range
    99..10391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001008348.1 polyprotein [Saint Louis encephalitis virus]

    See identical proteins and their annotated locations for YP_001008348.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M5UKF9, A1BQD2
    Conserved Domains (17) summary
    cd12149
    Location:596 → 688
    Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
    TIGR04240
    Location:693 → 789
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    smart00487
    Location:1680 → 1825
    DEXDc; DEAD-like helicases superfamily
    pfam01003
    Location:6 → 108
    Flavi_capsid; Flavivirus capsid protein C
    pfam00869
    Location:291 → 587
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
    pfam00948
    Location:791 → 1142
    Flavi_NS1; Flavivirus non-structural Protein NS1
    pfam00949
    Location:1518 → 1666
    Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
    pfam00972
    Location:2779 → 3418
    Flavi_NS5; Flavivirus RNA-directed RNA polymerase
    pfam01002
    Location:1373 → 1499
    Flavi_NS2B; Flavivirus non-structural protein NS2B
    pfam01004
    Location:220 → 288
    Flavi_M; Flavivirus envelope glycoprotein M
    pfam01005
    Location:1153 → 1339
    Flavi_NS2A; Flavivirus non-structural protein NS2A
    pfam01349
    Location:2267 → 2515
    Flavi_NS4B; Flavivirus non-structural protein NS4B
    pfam01350
    Location:2125 → 2264
    Flavi_NS4A; Flavivirus non-structural protein NS4A
    pfam01570
    Location:128 → 206
    Flavi_propep; Flavivirus polyprotein propeptide
    pfam01728
    Location:2579 → 2747
    FtsJ; FtsJ-like methyltransferase
    pfam07652
    Location:1685 → 1830
    Flavi_DEAD; Flavivirus DEAD domain
    cl21455
    Location:1856 → 1963
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. YP_009329944.1 anchored capsid protein anchC

  3. YP_009329945.1 core protein C

  4. YP_009329946.1 membrane glycoprotein precursor prM

  5. YP_009329947.1 protein pr

  6. YP_009329948.1 membrane glycoprotein M

  7. YP_009329949.1 envelope protein E

    UniProtKB/TrEMBL
    B3TMZ2, B3TN02, B3TN04, B3TN06, B3TN07, B3TN09, B3TN10

  8. YP_009329950.1 nonstructural protein NS1

  9. YP_009329951.1 nonstructural protein NS2A

  10. YP_009329952.1 nonstructural protein NS2B

  11. YP_009329953.1 nonstructural protein NS3

  12. YP_009329954.1 nonstructural protein NS4A

  13. YP_009329955.1 protein 2K

  14. YP_009329956.1 nonstructural protein NS4B

  15. YP_009329957.1 RNA-dependent RNA polymerase NS5

Nucleotide Protein
Heading Accession and Version

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