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comt - comatose

Predicted to enable ATP hydrolysis activity. Involved in several processes, including Golgi to lysosome transport; chemical synaptic transmission; and modulation of chemical synaptic transmission. Located in cytoplasm; neuromuscular junction of somatic muscle; and terminal bouton. Is active in neuromuscular junction and presynaptic cytosol. Colocalizes with synaptic vesicle. Is expressed in several structures, including adult head; central brain primordium; ganglia; sensory nervous system primordium; and synaptic neuropil domain. Used to study Parkinson's disease and epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 96. Orthologous to human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase). [provided by Alliance of Genome Resources, Oct 2024]

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Species Gene Architecture aa