PLCB1 phospholipase C beta 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: PLCB1provided by VGNC
Official Full Name: phospholipase C beta 1provided by VGNC
Primary source: VGNC:VGNC:6242
Locus tag: CK820_G0017580
See related: Ensembl:ENSPTRG00000013241
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	21	NC_072419.2 (14678105..15430326)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	20	NC_072418.1 (14689340..15441615)

Chromosome 21 - NC_072419.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AL031205 (e-PCR)
- UniSTS:71424

WI-17062 (e-PCR)
- UniSTS:73487

SHGC-152473 (e-PCR)
- UniSTS:182799

D20S851 (e-PCR)
- UniSTS:10773

Z94580 (e-PCR)
- UniSTS:20767

D20S594E (e-PCR)
- UniSTS:37163

Z94354 (e-PCR)
- UniSTS:45615

SHGC-151239 (e-PCR)
- UniSTS:173616

AL031206 (e-PCR)
- UniSTS:52548

SHGC-81474 (e-PCR)
- UniSTS:103504

PLCB1__1209 (e-PCR)
- UniSTS:277588

PLCB1__v332 (e-PCR)
- UniSTS:277588

SHGC-82613 (e-PCR)
- UniSTS:95606

RH104103 (e-PCR)
- UniSTS:98428

AB048884 (e-PCR)
- UniSTS:480132

Z94679 (e-PCR)
- UniSTS:66709

RH48470 (e-PCR)
- UniSTS:49561

A007B46 (e-PCR)
- UniSTS:3741

D20S580E (e-PCR)
- UniSTS:7842

RH92761 (e-PCR)
- UniSTS:88996

AL021622 (e-PCR)
- UniSTS:683

A006R17 (e-PCR)
- UniSTS:39851

Z94569 (e-PCR)
- UniSTS:33200

G18109 (e-PCR)
- UniSTS:82610

D20S879 (e-PCR), detects polymorphism
- UniSTS:6585

Z94672 (e-PCR)
- UniSTS:71357

Z94408 (e-PCR)
- UniSTS:2502

WI-17184 (e-PCR)
- UniSTS:30922

AFMa114xe5 (e-PCR)
- UniSTS:52938

SHGC-81138 (e-PCR)
- UniSTS:102354

STS-AA009431 (e-PCR)
- UniSTS:10198

D20S819 (e-PCR)
- UniSTS:59352

Z94577 (e-PCR)
- UniSTS:26585

Z94450 (e-PCR)
- UniSTS:16099

D20S177 (e-PCR), detects polymorphism
- UniSTS:12784

D20S177 (e-PCR), detects polymorphism
- UniSTS:12785

Homology

NCBI Orthologs

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in memory	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Names: phosphoinositide-specific phospholipase C beta 1; phospholipase C, beta 1 (phosphoinositide-specific)

XP_009435050.1

EC 3.1.4.11

XP_016792914.1

EC 3.1.4.11

XP_016792915.1

EC 3.1.4.11

XP_016792918.1

EC 3.1.4.11

XP_063659407.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072419.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

14678105..15430326

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016937425.4 → XP_016792914.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1

UniProtKB/TrEMBL

A0A2I3S8D6, A0A2J8MSP9, A0A6D2WK12

Conserved Domains (5) summary

cd00275
Location:681 → 800

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:320 → 647

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

cd13361
Location:22 → 152

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

cd16208
Location:157 → 307

EFh_PI-PLCbeta1; EF-hand motif found in phosphoinositide phospholipase C beta 1 (PI-PLC-beta1)

pfam08703
Location:1007 → 1176

PLC-beta_C; PLC-beta C terminal
XM_016937426.4 → XP_016792915.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X3

UniProtKB/TrEMBL

A0A2J8MSQ0

Conserved Domains (5) summary

cd00275
Location:681 → 800

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:320 → 647

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

cd13361
Location:22 → 152

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

cd16208
Location:157 → 307

EFh_PI-PLCbeta1; EF-hand motif found in phosphoinositide phospholipase C beta 1 (PI-PLC-beta1)

pfam08703
Location:1007 → 1145

PLC-beta_C; PLC-beta C terminal
XM_063803337.1 → XP_063659407.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X4

UniProtKB/TrEMBL

A0A2J8MSP2, A0A6D2XW72, K7DLT5
XM_009436775.4 → XP_009435050.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2

See identical proteins and their annotated locations for XP_009435050.1

UniProtKB/TrEMBL

A0A2I3S8D6, A0A2J8MSP1, A0A2J8MSP9, A0A6D2WK12, A0A6D2YBZ2, H2QJY4, K7BA21

Related

ENSPTRP00000022705.5

Conserved Domains (6) summary

cd00275
Location:677 → 796

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:316 → 643

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

cd13361
Location:22 → 148

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

cd16208
Location:153 → 303

EFh_PI-PLCbeta1; EF-hand motif found in phosphoinositide phospholipase C beta 1 (PI-PLC-beta1)

pfam06631
Location:903 → 939

DUF1154; Protein of unknown function (DUF1154)

pfam08703
Location:1003 → 1172

PLC-beta_C; PLC-beta C terminal
XM_016937429.4 → XP_016792918.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X5

UniProtKB/TrEMBL

A0A2I3S8D6, A0A2J8MSP9, A0A6D2WK12

Related

ENSPTRP00000073248.1

Conserved Domains (7) summary

cd00275
Location:576 → 695

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:215 → 542

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

PLN02952
Location:115 → 683

PLN02952; phosphoinositide phospholipase C

pfam06631
Location:802 → 838

DUF1154; Protein of unknown function (DUF1154)

pfam08703
Location:902 → 1071

PLC-beta_C; PLC-beta C terminal

pfam09279
Location:123 → 213

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cl17171
Location:1 → 47

PH-like; Pleckstrin homology-like domain