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WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [ Pan troglodytes (chimpanzee) ]

Gene ID: 468405, updated on 17-Aug-2024

Summary

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Official Symbol
WFIKKN2provided by VGNC
Official Full Name
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2provided by VGNC
Primary source
VGNC:VGNC:14226
Locus tag
CK820_G0021006
See related
Ensembl:ENSPTRG00000045369
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See WFIKKN2 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 19 NC_072417.2 (63972247..63979934)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 17 NC_072415.1 (62156376..62164389)

Chromosome 19 - NC_072417.2Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 40 Neighboring gene LUC7 like 3 pre-mRNA splicing factor Neighboring gene putative ANKRD40 C-terminal-like protein Neighboring gene uncharacterized LOC107969272 Neighboring gene transducer of ERBB2, 1 Neighboring gene sperm associated antigen 9 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2; WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072417.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    63972247..63979934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016932548.4 → XP_016788037.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A2J8MFR1
    Conserved Domains (4) summary
    cd05765
    Location:131 → 211
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:45 → 81
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd03575
    Location:362 → 470
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:292 → 343
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  2. XM_016932547.3 → XP_016788036.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A2I3T853, A0A2J8MFQ9, A0A6D2WD51
    Related
    ENSPTRP00000085402.1
    Conserved Domains (5) summary
    cd05765
    Location:224 → 304
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:138 → 174
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd03575
    Location:455 → 563
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:385 → 436
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:42 → 89
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
Nucleotide Protein
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