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dlt discs lost [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46719, updated on 4-Jul-2024

Summary

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Official Symbol
dltprovided by FlyBase
Official Full Name
discs lostprovided by FlyBase
Primary source
FLYBASE:FBgn0024510
Locus tag
Dmel_CG32315
See related
AllianceGenome:FB:FBgn0024510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1977; CG32315; Discs lost; Dlt; DLT; Dmel\CG32315; dre1; l(3)04276; l(3)62Ba; l(3)dre1; Van
Summary
Involved in imaginal disc morphogenesis; olfactory behavior; and regulation of cell population proliferation. Located in cytoplasm. Is expressed in several structures, including ectoderm; embryonic/larval digestive system; epithelium; furrow canal; and spermatozoon. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia and congenital dyserythropoietic anemia type Ia. Orthologous to human CDAN1 (codanin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See dlt in Genome Data Viewer
Location:
62B4-62B4; 3-1.0 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1789631..1795328, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1789631..1795328, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene alpha Spectrin Neighboring gene mitochondrial ribosomal protein L46 Neighboring gene antisense RNA:CR45834 Neighboring gene antisense RNA:CR45818 Neighboring gene Cell division cycle 37 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genetic architecture of quantitative traits: lessons from Drosophila. Mackay TF. Curr Opin Genet Dev, 2004 Jun. PMID 15172667
  2. DPATJ plays a role in retinal morphogenesis and protects against light-dependent degeneration of photoreceptor cells in the Drosophila eye. Richard M, et al. Dev Dyn, 2006 Apr. PMID 16245332
  3. Discs-Large and Strabismus are functionally linked to plasma membrane formation. Lee OK, et al. Nat Cell Biol, 2003 Nov. PMID 14562058, Free PMC Article
  4. Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior. Fanara JJ, et al. Genetics, 2002 Nov. PMID 12454076, Free PMC Article
  5. A conserved motif in Crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila. Klebes A, et al. Curr Biol, 2000 Jan 27. PMID 10662667

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in imaginal disc morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of a polarized epithelium TAS
Traceable Author Statement
more info
 PubMed 
involved_in olfactory behavior IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
discs lost
Names
CG32315-PA
dlt-PA
lethal(3)62Ba
vanaso

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1789631..1795328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167916.3 → NP_728672.1  discs lost [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728672.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T626, Q8T627, Q9W084
    Related
    FBpp0072673
    Conserved Domains (1) summary
    pfam15296
    Location:788 → 908
    Codanin-1_C; Codanin-1 C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T626.2 Q8T626

Gene LinkOut

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