U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HNRNPM heterogeneous nuclear ribonucleoprotein M [ Homo sapiens (human) ]

Gene ID: 4670, updated on 7-Apr-2024

Summary

Official Symbol
HNRNPMprovided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein Mprovided by HGNC
Primary source
HGNC:HGNC:5046
See related
Ensembl:ENSG00000099783 MIM:160994; AllianceGenome:HGNC:5046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEAR; HNRPM; HTGR1; NAGR1; HNRPM4; HNRNPM4; hnRNP M
Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 50.0), colon (RPKM 44.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See HNRNPM in Genome Data Viewer
Location:
19p13.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (8444975..8489114)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (8432898..8476696)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8509859..8553998)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RAB11B antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10021 Neighboring gene RAB11B, member RAS oncogene family Neighboring gene Sharpr-MPRA regulatory region 2878 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8477814-8478314 Neighboring gene Sharpr-MPRA regulatory region 12836 Neighboring gene GATA motif-containing MPRA enhancer 154 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8488918-8489781 Neighboring gene Sharpr-MPRA regulatory region 689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8563393-8564079 Neighboring gene PML-RARA regulated adaptor molecule 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8570689-8571189 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8571229-8571815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8576283-8577173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10030 Neighboring gene zinc finger protein 414

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Cellular biotinylated heterogeneous nuclear ribonucleoprotein M (HNRNPM) is incorporated into HIV-1 Gag virus-like particles PubMed
gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein M (HNRNPM), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPM is increased by RRE PubMed
Tat tat Heterogeneous nuclear ribonucleoprotein M (HNRNPM) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that HNRNPM gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with HNRNPM PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp547H118

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in paraspeckles IDA
Inferred from Direct Assay
more info
PubMed 
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein M
Names
CEA receptor
N-acetylglucosamine receptor 1
heterogenous nuclear ribonucleoprotein M4
hnRNA-binding protein M4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029850.1 RefSeqGene

    Range
    5057..49196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297418.2NP_001284347.1  heterogeneous nuclear ribonucleoprotein M isoform c

    See identical proteins and their annotated locations for NP_001284347.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform c, which has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AA244120, AB209733, CN350481, CN350526, HY007201
    UniProtKB/TrEMBL
    Q59ES8
    Conserved Domains (5) summary
    TIGR01628
    Location:82236
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12659
    Location:84159
    RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12661
    Location:519595
    RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    NF033916
    Location:279418
    antiphage_ZorA_3; anti-phage defense ZorAB system ZorA
    cl17169
    Location:127
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_005968.5NP_005959.2  heterogeneous nuclear ribonucleoprotein M isoform a

    See identical proteins and their annotated locations for NP_005959.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC000138, CN350526
    Consensus CDS
    CCDS12203.1
    UniProtKB/Swiss-Prot
    P52272, Q15584, Q8WZ44, Q96H56, Q9BWL9, Q9Y492
    UniProtKB/TrEMBL
    Q59ES8
    Related
    ENSP00000325376.2, ENST00000325495.9
    Conserved Domains (5) summary
    pfam11532
    Location:4170
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    cd12657
    Location:72147
    RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12659
    Location:204279
    RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12661
    Location:654730
    RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    NF033916
    Location:414553
    antiphage_ZorA_3; anti-phage defense ZorAB system ZorA
  3. NM_031203.4NP_112480.2  heterogeneous nuclear ribonucleoprotein M isoform b

    See identical proteins and their annotated locations for NP_112480.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    BC008895, BC058893, CN350526, DB478004
    Consensus CDS
    CCDS12204.1
    UniProtKB/TrEMBL
    Q59ES8
    Related
    ENSP00000325732.2, ENST00000348943.7
    Conserved Domains (5) summary
    pfam11532
    Location:4170
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    cd12657
    Location:72147
    RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12659
    Location:165240
    RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12661
    Location:615691
    RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    NF033916
    Location:375514
    antiphage_ZorA_3; anti-phage defense ZorAB system ZorA

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    8444975..8489114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272479.3XP_005272536.1  heterogeneous nuclear ribonucleoprotein M isoform X2

    See identical proteins and their annotated locations for XP_005272536.1

    UniProtKB/TrEMBL
    Q59ES8
    Conserved Domains (4) summary
    cd12386
    Location:206279
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12657
    Location:72147
    RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12661
    Location:636712
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    pfam11532
    Location:4270
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
  2. XM_005272478.4XP_005272535.1  heterogeneous nuclear ribonucleoprotein M isoform X1

    See identical proteins and their annotated locations for XP_005272535.1

    UniProtKB/TrEMBL
    Q59ES8
    Conserved Domains (5) summary
    pfam11532
    Location:4170
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    cd12657
    Location:72147
    RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12659
    Location:204279
    RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12661
    Location:639715
    RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    NF033916
    Location:399538
    antiphage_ZorA_3; anti-phage defense ZorAB system ZorA
  3. XM_017026823.2XP_016882312.1  heterogeneous nuclear ribonucleoprotein M isoform X3

    UniProtKB/TrEMBL
    Q59ES8
    Conserved Domains (5) summary
    TIGR01628
    Location:60373
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:206279
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12657
    Location:72147
    RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12661
    Location:621697
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    pfam11532
    Location:4270
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
  4. XM_017026824.2XP_016882313.1  heterogeneous nuclear ribonucleoprotein M isoform X5

    UniProtKB/TrEMBL
    Q59ES8
    Conserved Domains (4) summary
    cd12386
    Location:167240
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12661
    Location:597673
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    pfam11532
    Location:4270
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    cl17169
    Location:72147
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_005272480.3XP_005272537.1  heterogeneous nuclear ribonucleoprotein M isoform X4

    See identical proteins and their annotated locations for XP_005272537.1

    UniProtKB/TrEMBL
    Q59ES8
    Conserved Domains (5) summary
    pfam11532
    Location:4170
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    cd12657
    Location:72147
    RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12659
    Location:165240
    RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12661
    Location:600676
    RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    NF033916
    Location:360499
    antiphage_ZorA_3; anti-phage defense ZorAB system ZorA
  6. XM_017026825.2XP_016882314.1  heterogeneous nuclear ribonucleoprotein M isoform X6

    UniProtKB/TrEMBL
    Q59ES8
  7. XM_047438860.1XP_047294816.1  heterogeneous nuclear ribonucleoprotein M isoform X7

  8. XM_017026831.2XP_016882320.1  heterogeneous nuclear ribonucleoprotein M isoform X8

    UniProtKB/TrEMBL
    Q7KYM9
  9. XM_017026832.2XP_016882321.1  heterogeneous nuclear ribonucleoprotein M isoform X9

  10. XM_047438861.1XP_047294817.1  heterogeneous nuclear ribonucleoprotein M isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    8432898..8476696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321059.1XP_054177034.1  heterogeneous nuclear ribonucleoprotein M isoform X2

  2. XM_054321058.1XP_054177033.1  heterogeneous nuclear ribonucleoprotein M isoform X1

  3. XM_054321060.1XP_054177035.1  heterogeneous nuclear ribonucleoprotein M isoform X3

  4. XM_054321062.1XP_054177037.1  heterogeneous nuclear ribonucleoprotein M isoform X5

  5. XM_054321061.1XP_054177036.1  heterogeneous nuclear ribonucleoprotein M isoform X4

  6. XM_054321063.1XP_054177038.1  heterogeneous nuclear ribonucleoprotein M isoform X6

  7. XM_054321064.1XP_054177039.1  heterogeneous nuclear ribonucleoprotein M isoform X7

  8. XM_054321065.1XP_054177040.1  heterogeneous nuclear ribonucleoprotein M isoform X8

  9. XM_054321066.1XP_054177041.1  heterogeneous nuclear ribonucleoprotein M isoform X9

  10. XM_054321067.1XP_054177042.1  heterogeneous nuclear ribonucleoprotein M isoform X10